DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18600 and Polr1e

DIOPT Version :9

Sequence 1:	NP_650708.1	Gene:	CG18600 / 42201	FlyBaseID:	FBgn0038601	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001101408.1	Gene:	Polr1e / 313245	RGDID:	1565773	Length:	434	Species:	Rattus norvegicus

Alignment Length:	424	Identity:	95/424 - (22%)
Similarity:	176/424 - (41%)	Gaps:	70/424 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CDHKRDENIPTILKFQNGSLL--GDADFSMVEST------------VDGKKHALVYAGDQVYTGE 61
            |....|.....:::|.||.|.  |:..|::..||            :..:...|.|.|:...||.
  Rat    29 CGEPDDRQKAVLVQFSNGKLQNPGNMRFTLYNSTDLVNPRQKCHRILAAETDRLSYVGNNFGTGA 93

  Fly    62 VKDSEEVDTYIFIRNKLTNKVKVVPVQEALMYNHVYKKLERQKRTGPTMSREHANK----KL--- 119
            :|.:.....::.|.||.:.:::   |.:|.::|......|.....||.:  |:.||    ||
  Rat    94 LKCNTLCRHFVGILNKTSGQME---VYDAEVFNMQPLFAEDSIEHGPPL--ENQNKTFRDKLDSC 153

  Fly   120 LKEFGGRKASRFVDNREQMMVNVEVMR-------QDLDETVNSSMLNEDEEDGTLGDVSINNEEY 177
            ::.||..|..|.:::|....|..|.:.       :.:.:|...|.|..|    .:.|...|:..|
  Rat   154 IEAFGSTKQKRSLNSRRMNKVGSESLNFTVAKAAESIIDTKGVSALVSD----AMQDDLQNDSLY 214

  Fly   178 LASIVPEFNKEATKVDEVYAVESLIPSSLLERLE---EEAKVVFSTPVQTLPIKSEYLKSCLAKI 239
            |    |..:.:|||.::||..|.::..:..:.||   |..:.|.|..:..:..::.:....:..:
  Rat   215 L----PPCHADATKPEDVYRFEDILSPAEYDALESPSEAFRKVMSEDILKMVEENSHCSFIIEML 275

  Fly   240 QENPVSSKRDFLHIKLIIYMDALQSLISLRSRQMQKAELS---GITEKIENDIRHRFADPNVAKK 301
            :..|....:.....:.|.::||   |:..|::::.|.:.:   ||...|...:..:|........
  Rat   276 KSLPADEVQRNRQARSIWFLDA---LLRFRAQKVIKGKSALGPGIPHIINTKLLKQFTCLTYNNG 337

  Fly   302 GTRTNFSSE---KALTHFIVMALLLSEKFEVDINVLSRALATTKARIKQYAHIVN--------AL 355
            ..|...||.   |...:.|::||.:: .|::|:.||.|.|..::.|:.:.|..:.        :|
  Rat   338 SLRNLISSSMKAKITAYAIILALHIN-NFQIDLTVLQRDLKLSEKRMIEIARAMRLKISKRKVSL 401

  Fly   356 PKSNSD-----ILSLRLPSKVPALKSGRRFQRKK 384
            .....:     .||:.||   ||..|.|:.:|||
  Rat   402 ADGREEDHRLGTLSVPLP---PAQTSDRQSKRKK 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18600	NP_650708.1	RNA_pol_I_A49	33..379	CDD:284324	84/393 (21%)
Polr1e	NP_001101408.1	RNA_pol_I_A49	51..427	CDD:284324	85/395 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340675
Domainoid	1	1.000	52	1.000	Domainoid score	I11226
eggNOG	1	0.900	-	-		E1_KOG4183
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	58	1.000	Inparanoid score	I5322
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D346946at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14440
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.900