DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8064 and wdr3

DIOPT Version :9

Sequence 1:	NP_650705.1	Gene:	CG8064 / 42196	FlyBaseID:	FBgn0038597	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	NP_942574.1	Gene:	wdr3 / 321058	ZFINID:	ZDB-GENE-030131-9830	Length:	938	Species:	Danio rerio

Alignment Length:	954	Identity:	412/954 - (43%)
Similarity:	618/954 - (64%)	Gaps:	52/954 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGLTKQYLAYRAIDSFNIITSGRANVNFAVVDKTE-GRYVAAPAAENVIVWDLRMGDRKLTLRRE 64
            ||||||||.|.|...|.:|.|.:||:.|..:...| ||||||.|.|:|.:||:|..::.|.|..:
Zfish     1 MGLTKQYLRYVASAVFGVIGSQKANIAFVTLRGGEKGRYVAAGACEHVFIWDVRKAEKVLILEGK 65

  Fly    65 KFEVTSLRVSPDHLHIAVGYADGMVQIFDLSSDRYYDPICTLALHKNAVSILRYDLQGMRLVSGG 129
            |.|||.|..|||.:||||||.||.|:||.|.:.   :...:.:.||:|||:::||..|.|||:|.
Zfish    66 KHEVTYLCPSPDGVHIAVGYEDGGVRIFSLLNG---ESNVSFSGHKSAVSVIKYDALGARLVTGS 127

  Fly   130 LDTELVVVDVVEQAGRARLSGHNAAITDAHFLQRLVDESIVVSCSKDTQIKFWNLETQFCFKTIV 194
            .||:::|.||:.:.|..||.||..|||...||:   .::::::.|||:.:|:|:|:||.||||:|
Zfish   128 RDTDVIVWDVINECGLYRLKGHKDAITQVLFLE---SKNLLITSSKDSFVKWWDLDTQHCFKTMV 189

  Fly   195 DNRTEVWALAFIG--NLMVAGAGESGMNVYRLRKHDGA--ITETLESAVEGLSIDD--EDTISP- 252
            .:|:|||.:..:.  |.::.|:.:|.:..:.::..:..  :.|..|..|..| :||  ||...|
Zfish   190 GHRSEVWGMVLLNQENRLLTGSADSELRAWDIQDIEEVKELGEPQEKKVRTL-LDDEEEDEEGPD 253

  Fly   253 -------ISVSNCGTIQRAGKGRTVNLVTDPSERVISCHGTNDLIENFYICTPDEVKKRLAKRLK 310
                   :|..|.|:|.|..:.|.|:||||...:|::|||.:..:|.|.:.:.:|:::::.::||
Zfish   254 EEPEERILSCKNAGSILREARDRVVSLVTDAKAKVLACHGLDATLEVFTVLSEEEIQRKMDRKLK 318

  Fly   311 KEKKVAE-DEGSDEA-KLSTEQSLSDEIKRLESIRAKQKIKSIDVVLGQNQELRVLVSLANNSLC 373
            |.||.|: .||.:|| :...|:.|.|||.:|.:|||..||:|:|.:|..|.|::|::.|.||::.
Zfish   319 KAKKKAKSQEGGEEASEPVVERKLKDEIMKLANIRASSKIRSMDCLLVPNGEMKVVLLLQNNTVE 383

  Fly   374 LYSLEASIKTRKATDPSAKLLRSLTRLGHQSEVRSVCFSNDSLAIGSGAGESFKFWDRDAMQCLR 438
            .|:|:.:.|     :|:......||..||:|:||::.||:|::||.|.:|::.|.|:|..:|.:|
Zfish   384 TYTLKTTEK-----NPTGNKTSRLTLGGHRSDVRTLAFSSDNIAILSASGDTVKVWNRSTLQVIR 443

  Fly   439 TVPTDYILCSKFVPGDRYVLLGMKSGKLLIVDVAAADIVEEIPAHEGELWSIAILPDQKGCVTGS 503
            |:..:|.|||.||||||.::||.||||:.|.|:|:..::|...||||.|||:.:.|||:|.|||.
Zfish   444 TMGCEYALCSIFVPGDRQIILGSKSGKIQIFDLASGSLLETTDAHEGALWSMCLSPDQRGIVTGG 508

  Fly   504 GDTTVKIWTFELIDAGEGAAQTKVLSLLHKNTLKLEETVLCLAVSPDMKYLAVGLLDATVKVFFL 568
            .|.|||.|.|||| ..|.:...|.|::.|..||:|:|.|||:..|||.:.|||.|||.|||:|:.
Zfish   509 ADKTVKFWDFELI-KDEDSMINKRLTVKHTRTLQLDEDVLCVRFSPDQRLLAVSLLDCTVKIFYT 572

  Fly   569 DTFKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVWGLNFGDCHRSIFAHDDSVMSVQFIP 633
            ||.||:||||||||||:|||||:||.||.|||||||||:|||:|||||||:||||||||.:||:|
Zfish   573 DTLKFFLSLYGHKLPVLCLDISHDSALIATGSADRNVKIWGLDFGDCHRSMFAHDDSVMFLQFVP 637

  Fly   634 RTHMFFTCGKDGKVKQWDGDNFEKILTLPGHIGEAYCLSVSPNGRYLVTCGSDRTLRMFERTDET 698
            :||:|||.|||.|:||||.|.||.|.||.||..|.:||::||||.::|:...|::||::|||.|.
Zfish   638 KTHLFFTAGKDKKIKQWDADKFEHIQTLEGHHREVWCLAISPNGDHIVSSSHDKSLRLWERTREP 702

  Fly   699 IVLKDVQEEEREQMENEQLATGEDNTVPLLPG-----LKMPSRKTVGSEQSAESILECLEI---- 754
            |:|::.:|.|||....|.||.|:|   |::||     .:...||||.:.::||.|:|.:|:
Zfish   703 IILEEEKEMEREAEFEESLAKGDD---PVVPGETKGEAEPAGRKTVETVKAAERIMEAIELYREE 764

  Fly   755 SKQFE-----LEAEEKP----ELHPLMQALQVKNPEDFLVSTLMRIRASDLEEALLLLPFSTVCE 810
            ||..|     .||..|.    :::|::.|....:|..:::..:.::|:|:||.:||:|||..|.:
Zfish   765 SKNLEEHKAACEAAGKKLPPLKMNPILMAFGNISPSRYVLEVMKKVRSSELEVSLLVLPFPYVPD 829

  Fly   811 VLERLPTLLTQRPDQLELLCRVTIFLFKVHMKPISAAKNMKPLLVKLLSMLKRDVGQLRDVLGWN 875
            :| :|.....:...::||:||...||.:||...|::.:.:..::.:|.:.....|.::|||||:|
Zfish   830 LL-KLFNAYVKEGLEVELVCRCLFFLLRVHFGQITSNQMLLSVIDELRANTISKVREIRDVLGFN 893

  Fly   876 LHGLALLQTEVEQRDGVQLFREATQTRKKRDKKRREASKRRLQI 919
            ..||..||.|:|.|:.|..|.:||...:::.:|||:..:..|.|
Zfish   894 SAGLQFLQREIESREDVTFFADATDRFEEKKRKRRKRERVILTI 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8064	NP_650705.1	WD40	<45..288	CDD:225201	98/256 (38%)
		WD40	60..511	CDD:295369	187/466 (40%)
		WD40 repeat	69..108	CDD:293791	17/38 (45%)
		WD40 repeat	113..149	CDD:293791	16/35 (46%)
		WD40 repeat	156..194	CDD:293791	15/37 (41%)
		WD40 repeat	200..236	CDD:293791	6/39 (15%)
		WD40	331..702	CDD:225201	200/370 (54%)
		WD40 repeat	349..398	CDD:293791	13/48 (27%)
		WD40	401..693	CDD:238121	170/291 (58%)
		WD40 repeat	408..441	CDD:293791	13/32 (41%)
		WD40 repeat	446..482	CDD:293791	19/35 (54%)
		WD40 repeat	487..535	CDD:293791	23/47 (49%)
		WD40 repeat	543..578	CDD:293791	21/34 (62%)
		WD40 repeat	584..621	CDD:293791	29/36 (81%)
		WD40 repeat	626..662	CDD:293791	23/35 (66%)
		WD40 repeat	669..692	CDD:293791	10/22 (45%)
		Utp12	780..882	CDD:281932	32/101 (32%)
wdr3	NP_942574.1	WD40	<35..136	CDD:295369	50/103 (49%)
		WD40	57..692	CDD:225201	300/647 (46%)
		WD40 repeat	70..106	CDD:293791	17/38 (45%)
		WD40	104..517	CDD:238121	166/421 (39%)
		WD40 repeat	111..147	CDD:293791	16/35 (46%)
		WD40 repeat	154..189	CDD:293791	15/37 (41%)
		WD40 repeat	195..226	CDD:293791	5/30 (17%)
		WD40	400..697	CDD:238121	172/297 (58%)
		WD40 repeat	413..447	CDD:293791	13/33 (39%)
		WD40 repeat	452..487	CDD:293791	18/34 (53%)
		WD40 repeat	493..536	CDD:293791	21/43 (49%)
		WD40 repeat	546..582	CDD:293791	22/35 (63%)
		WD40 repeat	589..624	CDD:293791	28/34 (82%)
		WD40 repeat	630..666	CDD:293791	23/35 (66%)
		Utp12	799..900	CDD:281932	32/101 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595903
Domainoid	1	1.000	120	1.000	Domainoid score	I5730
eggNOG	1	0.900	-	-		E1_KOG0306
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4937
Inparanoid	1	1.050	739	1.000	Inparanoid score	I578
OMA	1	1.010	-	-		QHG54117
OrthoDB	1	1.010	-	-		D459903at2759
OrthoFinder	1	1.000	-	-		FOG0004801
OrthoInspector	1	1.000	-	-		oto40547
orthoMCL	1	0.900	-	-		OOG6_102330
Panther	1	1.100	-	-	LDO	PTHR19853
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1713
SonicParanoid	1	1.000	-	-		X3383
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800