DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8064 and WDR3

DIOPT Version :9

Sequence 1:	NP_650705.1	Gene:	CG8064 / 42196	FlyBaseID:	FBgn0038597	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	NP_006775.1	Gene:	WDR3 / 10885	HGNCID:	12755	Length:	943	Species:	Homo sapiens

Alignment Length:	955	Identity:	406/955 - (42%)
Similarity:	606/955 - (63%)	Gaps:	63/955 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGLTKQYLAYRAIDSFNIITSGRANVNFAVVDKTEGRYVAAPAAENVIVWDLRMGDRKLTLRREK 65
            ||||||||.|.|...|.:|.|.:.|:.|..:...:|||||.||.|:|.:||||.|::.|.|:..|
Human     1 MGLTKQYLRYVASAVFGVIGSQKGNIVFVTLRGEKGRYVAVPACEHVFIWDLRKGEKILILQGLK 65

  Fly    66 FEVTSLRVSPDHLHIAVGYADGMVQIFDLSSDRYYDPICTLALHKNAVSILRYDLQGMRLVSGGL 130
            .|||.|..|||.||:||||.||.::||.|.|.   :...|...||.|::.|:||..|.||.||..
Human    66 QEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSG---EGNVTFNGHKAAITTLKYDQLGGRLASGSK 127

  Fly   131 DTELVVVDVVEQAGRARLSGHNAAITDAHFLQRLVDESIVVSCSKDTQIKFWNLETQFCFKTIVD 195
            ||:::|.||:.::|..||.||..|||.|.||:   :::::|:..|||.:|:|:|:||.||||:|.
Human   128 DTDIIVWDVINESGLYRLKGHKDAITQALFLR---EKNLLVTSGKDTMVKWWDLDTQHCFKTMVG 189

  Fly   196 NRTEVWALAFIG--NLMVAGAGESGMNVY-----------------RLRKHDGAITETLESAVEG 241
            :|||||.|..:.  ..::.||.:|.:.|:                 :::.....|.:|||:....
Human   190 HRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIEDPEEPDPKKIKGSSPGIQDTLEAEDGA 254

  Fly   242 LSIDD--EDTISPISVSNCGTIQRAGKGRTVNLVTDPSERVISCHGTNDLIENFYICTPDEVKKR 304
            ...|:  ||.|  :|....|:|.|.|:.|.|||..|.:.|:::||||:.::|.|.|.:..|::|:
Human   255 FETDEAPEDRI--LSCRKAGSIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKK 317

  Fly   305 LAKRLKKEKKVAE---DEGSDE-AKLSTEQSLSDEIKRLESIRAKQKIKSIDVVLGQNQELRVLV 365
            :.|::||.:|.|:   .:|.:| .:::.|.||.|||:|:.:|:...||||.|::...:.||:.:.
Human   318 MDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVF 382

  Fly   366 SLANNSLCLYSLEASIKTRKATDPSAKLLRSLTRLGHQSEVRSVCFSNDSLAIGSGAGESFKFWD 430
            .|.||.:.||||..|:.|     |.......:|..||:|:||::.||:|::|:.|.|.:|.|.|:
Human   383 LLQNNLVELYSLNPSLPT-----PQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWN 442

  Fly   431 RDAMQCLRTVPTDYILCSKFVPGDRYVLLGMKSGKLLIVDVAAADIVEEIPAHEGELWSIAILPD 495
            |..:||:||:..:|.|||.||||||.|::|.|:|||.:.|:|:.:::|.|.||:|.|||:::.||
Human   443 RSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPD 507

  Fly   496 QKGCVTGSGDTTVKIWTFELIDAGEGAAQTKVLSLLHKNTLKLEETVLCLAVSPDMKYLAVGLLD 560
            |:|.|||..|.:||.|.|||: ..|.:.| |.||:....||:|:|.|||::.||:.|.|||.|||
Human   508 QRGFVTGGADKSVKFWDFELV-KDENSTQ-KRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLD 570

  Fly   561 ATVKVFFLDTFKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVWGLNFGDCHRSIFAHDDS 625
            .|||:|::||.||:||||||||||||:|||:|..||.|||||||||:|||:|||||:|:||||||
Human   571 CTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDS 635

  Fly   626 VMSVQFIPRTHMFFTCGKDGKVKQWDGDNFEKILTLPGHIGEAYCLSVSPNGRYLVTCGSDRTLR 690
            ||.:||:|::|:|||.|||.|:||||.|.||.|.||.||..|.:||:|||:|.|:|:...|::||
Human   636 VMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLR 700

  Fly   691 MFERTDETIVLKDVQEEEREQMENEQLATGEDNTVPLLPG-----LKMPSRKTVGSEQSAESILE 750
            ::|||.|.::|::.:|.||| .|.|:....||.  |.:||     .....:||:.:.::||.|:|
Human   701 LWERTREPLILEEEREMERE-AEYEESVAKEDQ--PAVPGETQGDSYFTGKKTIETVKAAERIME 762

  Fly   751 CLEISKQFELEAEEKPEL------------HPLMQALQVKNPEDFLVSTLMRIRASDLEEALLLL 803
            .:|:.::...:.:|...:            :|::.|....:|..:::.....|::|:|||:||:|
Human   763 AIELYREETAKMKEHKAICKAAGKEVPLPSNPILMAYGSISPSAYVLEIFKGIKSSELEESLLVL 827

  Fly   804 PFSTVCEVLERLPTLLTQRPDQLELLCRVTIFLFKVHMKPISAAKNMKPLLVKLLSMLKRDVGQL 868
            |||.|.::| :|.....|....:||:||...||.::|...|::.:.:.|::.||.......|.|:
Human   828 PFSYVPDIL-KLFNEFIQLGSDVELICRCLFFLLRIHFGQITSNQMLVPVIEKLRETTISKVSQV 891

  Fly   869 RDVLGWNLHGLALLQTEVEQRDGVQLFREATQ--TRKKRDKKRRE 911
            |||:|:|:.||..|:.|.|.:..|..|.:||.  ..|||.:|:||
Human   892 RDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKRE 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8064	NP_650705.1	WD40	<45..288	CDD:225201	104/263 (40%)
		WD40	60..511	CDD:295369	189/475 (40%)
		WD40 repeat	69..108	CDD:293791	18/38 (47%)
		WD40 repeat	113..149	CDD:293791	15/35 (43%)
		WD40 repeat	156..194	CDD:293791	17/37 (46%)
		WD40 repeat	200..236	CDD:293791	9/54 (17%)
		WD40	331..702	CDD:225201	196/370 (53%)
		WD40 repeat	349..398	CDD:293791	15/48 (31%)
		WD40	401..693	CDD:238121	167/291 (57%)
		WD40 repeat	408..441	CDD:293791	14/32 (44%)
		WD40 repeat	446..482	CDD:293791	19/35 (54%)
		WD40 repeat	487..535	CDD:293791	22/47 (47%)
		WD40 repeat	543..578	CDD:293791	21/34 (62%)
		WD40 repeat	584..621	CDD:293791	27/36 (75%)
		WD40 repeat	626..662	CDD:293791	22/35 (63%)
		WD40 repeat	669..692	CDD:293791	11/22 (50%)
		Utp12	780..882	CDD:281932	36/101 (36%)
WDR3	NP_006775.1	WD40	<21..104	CDD:225201	40/85 (47%)
		WD 1	21..60		17/38 (45%)
		WD40	47..>226	CDD:295369	80/184 (43%)
		WD 2	63..102		20/41 (49%)
		WD40 repeat	68..104	CDD:293791	19/38 (50%)
		WD40	85..698	CDD:225201	284/627 (45%)
		WD 3	105..144		17/38 (45%)
		WD40 repeat	111..146	CDD:293791	15/34 (44%)
		WD 4	147..186		19/41 (46%)
		WD40 repeat	152..188	CDD:293791	18/38 (47%)
		WD 5	189..228		10/38 (26%)
		WD40 repeat	194..220	CDD:293791	7/25 (28%)
		WD 6	277..316		15/38 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..345		4/18 (22%)
		WD40	407..703	CDD:238121	168/297 (57%)
		WD 7	413..451		17/37 (46%)
		WD40 repeat	420..454	CDD:293791	14/33 (42%)
		WD 8	453..493		19/39 (49%)
		WD40 repeat	462..494	CDD:293791	16/31 (52%)
		WD 9	494..533		21/39 (54%)
		WD40 repeat	500..548	CDD:293791	23/49 (47%)
		WD 10	547..586		22/38 (58%)
		WD40 repeat	552..588	CDD:293791	22/35 (63%)
		WD 11	589..630		32/40 (80%)
		WD40 repeat	595..630	CDD:293791	26/34 (76%)
		WD 12	631..670		26/38 (68%)
		WD40 repeat	636..672	CDD:293791	22/35 (63%)
		WD 13	673..712		18/38 (47%)
		Utp12	804..905	CDD:281932	36/101 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159687
Domainoid	1	1.000	104	1.000	Domainoid score	I6723
eggNOG	1	0.900	-	-		E1_KOG0306
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4937
Inparanoid	1	1.050	741	1.000	Inparanoid score	I592
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54117
OrthoDB	1	1.010	-	-		D459903at2759
OrthoFinder	1	1.000	-	-		FOG0004801
OrthoInspector	1	1.000	-	-		oto89797
orthoMCL	1	0.900	-	-		OOG6_102330
Panther	1	1.100	-	-	LDO	PTHR19853
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1713
SonicParanoid	1	1.000	-	-		X3383
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800