DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7142 and HGF

DIOPT Version :9

Sequence 1:	NP_650703.1	Gene:	CG7142 / 42194	FlyBaseID:	FBgn0038595	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_000592.3	Gene:	HGF / 3082	HGNCID:	4893	Length:	728	Species:	Homo sapiens

Alignment Length:	231	Identity:	71/231 - (30%)
Similarity:	113/231 - (48%)	Gaps:	34/231 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 HYCAGTIINEHWILTAAHCLSSPQAVENSVIVAGSHDIHDQKGEASNIQMRHIDYYVRHELYLGG 172
            |.|.|::|.|.|:|||..|..| :.:::.....|.||:|. :|:....|:.::...|.      |
Human   517 HICGGSLIKESWVLTARQCFPS-RDLKDYEAWLGIHDVHG-RGDEKCKQVLNVSQLVY------G 573

  Fly   173 VNPYDIALIYTKEPLVFDTYVQPATLPEQDAQPEGYG---------TLYGWGNVSMTAVPNYPHR 228
            ....|:.|:....|.|.|.:|....||       .||         ::||||   .|.:.||...
Human   574 PEGSDLVLMKLARPAVLDDFVSTIDLP-------NYGCTIPEKTSCSVYGWG---YTGLINYDGL 628

  Fly   229 LQEANMPILDMELCEQILARSGLPLHETNLCTGPLTGGVSICTADSGGPLIQQCCEEHFEQANIV 293
            |:.|::.|:..|.|.| ..|..:.|:|:.:|.|....|...|..|.||||:   ||:|  :..:|
Human   629 LRVAHLYIMGNEKCSQ-HHRGKVTLNESEICAGAEKIGSGPCEGDYGGPLV---CEQH--KMRMV 687

  Fly   294 IGIVSWGKMPCGQKNAPSVFVRVSAFTEWINQVIST 329
            :|::..|: .|...|.|.:||||:.:.:||:::|.|
Human   688 LGVIVPGR-GCAIPNRPGIFVRVAYYAKWIHKIILT 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7142	NP_650703.1	Tryp_SPc	84..326	CDD:238113	69/226 (31%)
CG7142	NP_650703.1	Tryp_SPc	84..323	CDD:214473	67/223 (30%)
HGF	NP_000592.3	PAN_APPLE	39..122	CDD:238074
		KR	126..208	CDD:214527
		KR	210..290	CDD:214527
		KR	304..384	CDD:214527
		KR	388..470	CDD:238056
		Tryp_SPc	494..716	CDD:214473	67/223 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7084
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950