DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7142 and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_650703.1	Gene:	CG7142 / 42194	FlyBaseID:	FBgn0038595	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	262	Identity:	71/262 - (27%)
Similarity:	113/262 - (43%)	Gaps:	42/262 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 PYVVSIQMMTPDQGLVHYCAGTIINEHWILTAAHCL---SSPQAVENSVIVAGSHDIHDQKGEAS 153
            |:..|:|:    :|. |.|.|.:|.:.|::|||||.   |....|..:|.:..........||.|
Human   580 PWQASLQV----RGR-HICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVS 639

  Fly   154 NIQMRHIDYYVRHELYLGGVNPYDIALIYTKEPLVFDTYVQPATLPEQD--AQP------EGYGT 210
                ..:...:.|..:....:.||:||:....|:|....|:|..||.:.  .:|      .|:|.
Human   640 ----FKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGA 700

  Fly   211 L-------------YGWGNV-SMTAVPNYPHRLQEANMPILDMELCEQILARSGLPLHETNLCTG 261
            |             |||.|. |.|......:.||:.::.::..:||.::......|   ..||.|
Human   701 LREGALRADAVALFYGWRNQGSETCCCPISNALQKVDVQLIPQDLCSEVYRYQVTP---RMLCAG 762

  Fly   262 PLTGGVSICTADSGGPLIQQCCEEHFEQANIVIGIVSWGKMPCGQKNAPSVFVRVSAFTEWINQV 326
            ...|....|..||||||:.:.....:    .:.|:|||| :.||:.|...|:.|::....||.||
Human   763 YRKGKKDACQGDSGGPLVCKALSGRW----FLAGLVSWG-LGCGRPNYFGVYTRITGVISWIQQV 822

  Fly   327 IS 328
            ::
Human   823 VT 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7142	NP_650703.1	Tryp_SPc	84..326	CDD:238113	69/258 (27%)
CG7142	NP_650703.1	Tryp_SPc	84..323	CDD:214473	67/255 (26%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060
		LDLa	486..516	CDD:238060
		Ldl_recept_a	520..557	CDD:278486
		Tryp_SPc	568..822	CDD:238113	69/258 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920