DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Vps39 and TGFBRAP1

DIOPT Version :9

Sequence 1:NP_650702.1 Gene:Vps39 / 42192 FlyBaseID:FBgn0038593 Length:876 Species:Drosophila melanogaster
Sequence 2:NP_001136093.1 Gene:TGFBRAP1 / 9392 HGNCID:16836 Length:860 Species:Homo sapiens


Alignment Length:896 Identity:217/896 - (24%)
Similarity:391/896 - (43%) Gaps:116/896 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 KQGVQIESIAAYGNHVILGTRSGQLIMYSVDEE-------TGVDMRMFNKNFS-RKPITQMEVIA 68
            |:.|.||.:...|..:.:||....:..:.::|.       |....:...::.. :||:.::...:
Human    22 KERVNIECVECCGRDLYVGTNDCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPVNELRAAS 86

  Fly    69 SENLLFVLTDLQVQVCDIRRIESNFAFMHSAPDTKGCTLFTMDVDTPKSTTGRVATVIRVC-CAI 132
            :.|.|.||.|..:.:.::..:|.    :.|....||...|.:: :.|.|..   ...:.|| .::
Human    87 ALNRLLVLCDNSISLVNMLNLEP----VPSGARIKGAATFALN-ENPVSGD---PFCVEVCIISV 143

  Fly   133 RRRLV-FFFWKEDKLNSLELIIELS--DVPRTLCWVGHAVCVGFKDEYVVYDISGKAPKKHNLFL 194
            :||.: .|...||:   ::::.|:|  :.|..:...||.:|:....:|::::.|  .....:||.
Human   144 KRRTIQMFLVYEDR---VQIVKEVSTAEQPLAVAVDGHFLCLALTTQYIIHNYS--TGVSQDLFP 203

  Fly   195 TSSSISRDPCICLIRNNMLGISKDSYLVVVDPSQYKESDGINNSTDVRPAAMDSNSSLTPLLWSS 259
            ..|. .|.|.:       ..|.:..:| :..|.      |:...     |.:...|...|:.||.
Human   204 YCSE-ERPPIV-------KRIGRQEFL-LAGPG------GLGMF-----ATVAGISQRAPVHWSE 248

  Fly   260 PLLDLVWDEPFAVGRVNNAIEVRSLVGKDTLVQTIPELQKTKFLVHADKGTIFAAATSELWCIRM 324
            .::......|:.:...:..|.|.|::.:.. .||:|  .|...::...:|.:..|.:..::.  :
Human   249 NVIGAAVSFPYVIALDDEFITVHSMLDQQQ-KQTLP--FKEGHILQDFEGRVIVATSKGVYI--L 308

  Fly   325 VEIPIQR--QQLLQQKKFQLAIELTQISDEPAADRAQTIRQIHMLYAKEL-------FTNKEFSA 380
            |.:|:::  |.||..::.:.|:.|.:     .|.|.....:..::|.:.|       |...:|..
Human   309 VPLPLEKQIQDLLASRRVEEALVLAK-----GARRNIPKEKFQVMYRRILQQAGFIQFAQLQFLE 368

  Fly   381 AMKEFEKAAIDPYDVIRLFPNLVPEPKPGTEDVTVPTSSTPALEDSDLENAYLALIEYLAWARQR 445
            |.:.|....:|..::|.|:|.|:|.....|.      |..|..|.:||........|.:|..::.
Human   369 AKELFRSGQLDVRELISLYPFLLPTSSSFTR------SHPPLHEYADLNQLTQGDQEKMAKCKRF 427

  Fly   446 EVVKLRDTKSS--SKSLLEIIDTTLLKCYLQT-NDSLVAPLLRLNQCHLEESEKTLKKHNKISEL 507
            .:..|.:.:|:  :....|.|||.|||.|.:. :|||:..|:..|.|.|.:|...|:||.|...|
Human   428 LMSYLNEVRSTEVANGYKEDIDTALLKLYAEADHDSLLDLLVTENFCLLTDSAAWLEKHKKYFAL 492

  Fly   508 IILYQMKGKHKEALKLLREQASIEGSVLQGRKRTIRYLQELGGDHL------PLIFEFADWVLND 566
            .:||....:...|::|   ..:|....:|...|:..|  |...|.|      .|::.:|||||..
Human   493 GLLYHYNNQDAAAVQL---WVNIVNGDVQDSTRSDLY--EYIVDFLTYCLDEELVWAYADWVLQK 552

  Fly   567 NPEEGLTIFTDELIEVESLPRAKVLDFF--ISKHKALVIPYLEHVITEWKDGNTLLHNVLLKQYR 629
            :.|.|:.:||...::.:........|..  :.|:...::.||||::.:.:......|..|...|.
Human   553 SEEVGVQVFTKRPLDEQQKNSFNPDDIINCLKKYPKALVKYLEHLVIDKRLQKEEYHTHLAVLYL 617

  Fly   630 EKV--QRLLAQQEKGEEVPELIPMRAKLYKMLEESNDYSPDRLLEEFPTNILLEERALILGRLKK 692
            |:|  ||..| ..||.|..|   .:|||.::|::|:.|....|||......|..|.|::.|:|.:
Human   618 EEVLLQRASA-SGKGAEATE---TQAKLRRLLQKSDLYRVHFLLERLQGAGLPMESAILHGKLGE 678

  Fly   693 HDNVLSIYIHVLGDVAKATAYAE--AHYKEDKH---IFHTLIKCILIPPTQPLYDGVPLHPDFSQ 752
            |:..|.|.:|.|.|.|.|..|..  :..::..|   :||||:...       |:.|...|     
Human   679 HEKALHILVHELQDFAAAEDYCLWCSEGRDPPHRQQLFHTLLAIY-------LHAGPTAH----- 731

  Fly   753 VNREV---ALEILNTHATRIDPFEIFEHLPDDMPMPQLEKYLEKSIRKMMADKHEMQMMCGFLEA 814
               |:   |:::||.|||..|..::.:.|||...:..|..:|..::|..:..:..||:..|...:
Human   732 ---ELAVAAVDLLNRHATEFDAAQVLQMLPDTWSVQLLCPFLMGAMRDSIHARRTMQVALGLARS 793

  Fly   815 ESTRLENALEEQRNISFELNESSVCSECKKRFQTQSAFVRYPNGHIVHLSC 865
            |:........:.:..|.:|::..:|..|:..| .:..|||||||.:||..|
Human   794 ENLIYTYDKMKLKGSSIQLSDKKLCQICQNPF-CEPVFVRYPNGGLVHTHC 843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Vps39NP_650702.1 CNH 24..304 CDD:295303 56/291 (19%)
Vps39_1 464..564 CDD:287352 35/106 (33%)
Vps39_2 759..868 CDD:287353 31/107 (29%)
TGFBRAP1NP_001136093.1 CNH 87..283 CDD:321933 47/229 (21%)
Vps39_1 448..550 CDD:313568 35/106 (33%)
CHCR 564..728 47/174 (27%)
Clathrin 585..699 CDD:306985 39/117 (33%)
Vps39_2 738..846 CDD:313569 31/107 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 60 1.000 Domainoid score I10635
eggNOG 1 0.900 - - E1_KOG2063
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54136
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1627
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.850

Return to query results.
Submit another query.