DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps39 and VPS3

DIOPT Version :9

Sequence 1:	NP_650702.1	Gene:	Vps39 / 42192	FlyBaseID:	FBgn0038593	Length:	876	Species:	Drosophila melanogaster
Sequence 2:	NP_010783.3	Gene:	VPS3 / 852106	SGDID:	S000002903	Length:	1011	Species:	Saccharomyces cerevisiae

Alignment Length:	998	Identity:	188/998 - (18%)
Similarity:	340/998 - (34%)	Gaps:	308/998 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AYGNHVILGTRSGQLIMYSVDEETGVDMRMFNKNFSRKPITQMEVIA-------------SENLL 73
            ||.||:.|||.:|.|:.| .:.|.|..|.:....|..:..::::.|.             :|.:|
Yeast   151 AYENHIFLGTTTGDLLHY-FELERGNYMLVSQTKFDAESNSKIDKILLLPKVEGALILCDNELVL 214

  Fly    74 FVLTDL-------------QVQVCDIRRIESNFAFMHSAPDTKGCTLFTMDVDTPKSTTGRVATV 125
            |:|.:.             .|.:|:..|  |:.|:...|...:|..|..:..|:...|......:
Yeast   215 FILPEFAPRPNTTRLKGISDVVICNFSR--SSKAYRIYAFHAEGVRLLKISADSLVLTKAFNFKL 277

  Fly   126 IRVCCAIRRRLVFFFWKEDKLNSLELI----------IELSDVPRTLCWVGHAVCVGFKD--EYV 178
            |...||....|:.     .||||.|||          ..:|:....|    ..:...|.:  |::
Yeast   278 IDKACAHEETLMV-----SKLNSYELINLKSSQVIPLFRISETDEDL----EPIITSFNEQSEFL 333

  Fly   179 V------YDISGKAPKKHNLFLTSSSISRDPCICLIRNNMLGISKDSYLV------VVDPSQYKE 231
            |      || ||                   .:.|:.|:...|.|.:.::      |:....|..
Yeast   334 VCSGGGSYD-SG-------------------AMALVVNHHGDIIKGTIVLKNYPRNVIVEFPYII 378

  Fly   232 SDGINNSTDVRPAAMDSNSSLTPLLWSS------PLLDLVW-----DEPFAVGRVNNAIEVRSLV 285
            ::....|.|:..|.....|.|...:.:|      ...|.|:     .|.|. .::.|.:.:..|.
Yeast   379 AESAFQSVDIYSALPSEKSQLLQSITTSGSDLKISKSDNVFTNTNNSEEFK-EKIFNKLRLEPLT 442

  Fly   286 GKDTLVQTIPEL--------QKTKFLVHADKGTIFAAAT-----------SELWCI--RMVEIP- 328
            ..|...:...|.        :||..:|:.:.|......|           ||:..|  ::.::.
Yeast   443 HSDNKFRIERERAFVEESYEEKTSLIVYNNLGIHLLVPTPMVLRFTSCEESEIDNIEDQLKKLAK 507

  Fly   329 --------IQRQQLLQQKKFQLAIELTQISDE------PAADRAQTIRQIHMLYAKELFTNKEFS 379
                    |:.:.|:....|.:.:....|.||      ..:|:.. ||.:..::..::
Yeast   508 KDLTKFEHIEAKYLMSLLLFLMTLHYDHIEDEVMKKWCDFSDKVD-IRILFYMFGWKV------- 564

  Fly   380 AAMKEFEKAAIDPYDVIRLFPNLVPEPKPGTEDVTVPTSSTPALEDSDLENAYLALIEYLAWARQ 444
                         |..|..|..|:              :....|:...|.|....:::.|...:
Yeast   565 -------------YSEIWCFHGLI--------------NIVERLKSLKLTNKCENILKMLLMMK- 601

  Fly   445 REVVKLRDT---KSSSKSLLEIIDTTLLKCYLQTNDSLVAPLLRLNQCHLEESEKTLKKHN---- 502
            .|:.|...|   .:....:::.||.||.|..|:..:::...:.....  .:|..:.:..|:
Yeast   602 NELKKKNKTGLLTNDFDDIMKTIDITLFKLRLEKKETITVDMFERES--YDEIIREINLHDDKLP 664

  Fly   503 KISELIILYQMKGKHKEALKLLREQAS-------IEGSVLQGRKRTIRYLQELGGDHLPLIFEFA 560
            :|..||.:|:.||::.:||.||||...       ||.::   :|....|::|...|.|.|..:..
Yeast   665 RIELLIEIYKEKGEYLKALNLLREAGDYISLVSFIEENL---KKLPEDYIKERIADDLLLTLKQG 726

  Fly   561 DW-----------------------VLNDNP--EEGLTIFTDELIEVESLPRAKVL-DFFISK-- 597
            |.                       .||..|  |..|.:...|.:.|::...:|.| :::::|
Yeast   727 DENTEECAIKKVLKILDMACINKNDFLNKIPAEETSLKVSFIEQLGVQNSNDSKFLFNYYLAKLR 791

  Fly   598 ---HKALVIPYLEHVITEWKDG--------NTLLHNVLLK---------QYREKVQRLLAQQEKG 642
               :::.:...|...|.|:||.        ...:| :.||         :|.||.:.|.::.||.
Yeast   792 EIINQSNIWSILGDFIKEYKDDFAYDKTDITNFIH-IKLKHSLQCENFSKYYEKCENLKSENEKD 855

  Fly   643 EEVPELIPMRAKLYKMLEESNDYSPDRLLE--EFP---TNILLEERALILGRLKKHDNVLSIYIH 702
            :|.         :....:|.:....:.:|.  .||   ||.:..|            .:|.||:.
Yeast   856 DEF---------INFTFDEISKIDKEHILTLLFFPNELTNWVSSE------------ELLKIYLS 899

  Fly   703 VLGDVAKATAYAEAHYKEDKHIFHTLIKCILIPPTQPLYDGVPLHPDFSQVNREVAL--EILNTH 765
            .                   :.|.::.|.|   ..|.|...:..:.|.|.:|..|.|  .:|..:
Yeast   900 F-------------------NDFRSVEKYI---GKQNLVAVMKQYLDISSLNYSVELVTNLLQRN 942

  Fly   766 ATRID----PFEIFEHLPDDMPMPQLEKYLEKSIRKMMADKHEMQMMCGFLEAESTRLENALEEQ 826
            ...:|    ..:|.|.:|...|:..:.:.|.|.:.|....|.|..:....|:
Yeast   943 FELLDDTDIQLKILETIPSVFPVQTISELLLKVLIKYQEKKEESNLRKCLLK------------- 994

  Fly   827 RNISFELNESSVCSECKKRFQTQ 849
                   |:.|:..|..:.|.:|
Yeast   995 -------NQISISDELSRNFDSQ 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps39	NP_650702.1	CNH	24..304	CDD:295303	69/348 (20%)
		Vps39_1	464..564	CDD:287352	29/133 (22%)
		Vps39_2	759..868	CDD:287353	18/97 (19%)
VPS3	NP_010783.3	MDN1	<11..120	CDD:227596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2063
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	73	1.000	Inparanoid score	I1678
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12894
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1627
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.080