Protein Alignment Vps39 and VAM6

DIOPT Version :9

• Sequence 1: NP_650702.1
• Gene: Vps39 / 42192
• FlyBaseID: FBgn0038593
• Length: 876
• Species: Drosophila melanogaster
• Sequence 2: NP_010206.1
• Gene: VAM6 / 851482
• SGDID: S000002235
• Length: 1049
• Species: Saccharomyces cerevisiae
• Alignment Length: 1094
• Identity: 232/1094 - (21%)
• Similarity: 398/1094 - (36%)
• Gaps: 307/1094 - (28%)

  Fly     1 MHQAYSVHSILKQGVQIESIAAYGNHVILGTRSGQLIMYSVDEETGVDMRMFN---------KNF 56
            |.:|..:||:....:...........::|..::|.:.:||.|..|   :::|.         ||.
Yeast     1 MLRAQKLHSLKSSDITAILPTEQSQKLVLAKKNGDVEVYSRDGNT---LKLFQVYPDLLQNAKND 62

  Fly    57 SRKPITQMEVIASE-----------NLLFVLTDLQV--QVCDIRRIESNFAF--MHSAPDTKGCT 106
            ...|:.:....|:|           .:|...|:|..  ::.|.|.|...:.|  .|...:.|...
Yeast    63 PLPPVIENFYFANELSTIFAQCKETLILLSTTNLHEYDRIIDRRGINHCWLFERSHKNKEEKNTY 127

  Fly   107 LFTMDVDTPKSTT----GRV-ATVIRVCCAIRRRLV-----------------FFFWKEDK--LN 147
            |....::|.|...    ||. ..::....:.|:..:                 .:.|..:|  |.
Yeast   128 LIYSTINTAKMRVLIWEGRTYKNMMEASLSYRKETIRSIYPGETGITLATDLGIYHWPYNKPSLI 192

  Fly   148 SLELIIELSDVPRTLCWVGHAVCVGFKDEYVVYDISGKAPKKHNLFLTSSSISRD---------- 202
            .:|..:: :..|:.:.    :.....|::  ...:..|.|||::.|...|..|.|
Yeast   193 RIEKTVK-NKFPKDMI----SALTELKEQ--AEKVIEKKPKKNSHFDAQSFSSMDRMSRKSSMSS 250

  Fly   203 --------------------------PCIC-----------LIRNNMLGISKDSYLVVVDPSQYK 230
                                      |.|.           |:.||     ::.:|:..|.:.:.
Yeast   251 LWYRTIRNERGNKIRYTFELDGNDATPMIIDGATKKIFKVELMHNN-----EEPFLIATDHATFS 310

  Fly   231 ESDGINNSTDVRPAAMDSNSSLTPLLWSSPLLDLVWDE---PFAVGRVNNAIE-VRSLVGKDTLV 291
            ||   |:..|    .|...||...:|::|..:..|..|   .|...::...|: |::|.|...||
Yeast   311 ES---NSEFD----HMQYLSSNLLMLYNSSTIKFVDYENGFTFLQQKIPEGIKWVKNLSGTYFLV 368

  Fly   292 QTI-PELQKTKFLVHADKGT------------------------------IFAAATSEL------ 319
            .|. .|:|  .|..|.|.|:                              |.:..:.||
Yeast   369 WTSNDEVQ--LFSYHVDDGSEDDDQESICGDINDPDFYQLWRKVLFYKFFIDSPHSKELCVSDNP 431

  Fly   320 -----------------WCIR--------MVEIPIQR-QQLLQQK--------------KFQLAI 344
                             ||:|        ||::...| .::::.|              ||....
Yeast   432 EESLDICAMKLRDLTVMWCLRIFDKFQNYMVQLERSRNSRMIRSKCEEMIIKSIFDLFIKFWAPP 496

  Fly   345 ELTQISDEPAADRAQTIRQIHMLYAKELFTNKEFSAAMKEFEKAAIDPYDVIRLFPNLVPE-PKP 408
            :|..:...|:|..:..:.          .|.:|....:||.|:.. :.||:.   |:|:.. ..|
Yeast   497 QLVILKVFPSAISSLVLE----------ITGQEHHCLLKEAEEVK-ETYDIP---PHLLNRWCLP 547

  Fly   409 GTEDVTVPTSSTPALEDSDLENAYLALIEYLAWA-RQREVVKLRDTKSSS-------KSLLEIID 465
            ...|......:..:.|:.|...        :.|. |.||:.:..|....|       .::|.:||
Yeast   548 YLTDTRRHLQNLLSKENDDESR--------ITWCYRDREIKQSFDFFLISNHDDVDLNTMLTLID 604

  Fly   466 TTLLKCYLQTNDSLVAPLLRL-NQCHLEESEKTLKKHNKISELIILYQMKGKHKEALKLLREQA- 528
            |.|.||||..|..:|.|.:|: |.|........||..:...:||..|..:|.|:||||.|.:..
Yeast   605 TVLFKCYLYYNPPMVGPFIRVENHCDSHVIVTELKIRHMFKDLIDFYYKRGNHEEALKFLTDLVD 669

  Fly   529 SIEGSVLQGRKR----------TIRYLQELGGDHLPLIFEFADWVL---NDNPEEGL-TIFTDEL 579
            .:|......::|          .|.||::|....|.:||.:.||:|   ||:.:|.| :||..:.
Yeast   670 ELENDNTDQKQRQKIDHGVKILVIYYLKKLSNPQLDVIFTYTDWLLNRHNDSIKEILSSIFFYDS 734

  Fly   580 IEVESLPRAKVLDFFISKHKALVIPYLEHVITEWK-DGNTLLHNVLLKQYREKVQRLLAQQEKGE 643
            ....|....||..:.....|.|.|.|||..|:.:: :||. ||.||:|.|.|.:
Yeast   735 QACSSRDHLKVYGYIKKFDKLLAIQYLEFAISTFRLEGNK-LHTVLIKLYLENL----------- 787

  Fly   644 EVPELIPMRAKLYKMLEESNDYSPDRLL-----------EEFPTNILLEERAL---ILGRLKKHD 694
            ::|.   .|.||..:||.::.|.|..:|           ::.|||.|...:.|   .|.:|:.|.
Yeast   788 DIPS---TRIKLKSLLETTSVYEPRTILKLLNDAIESGSDQLPTNQLNFVKYLKIFPLSKLENHK 849

  Fly   695 NVLSIYIHVLGDVAKATAYAEAHYKEDK--------HIFHTLIKCILIPPTQPLYDGVPLHPDFS 751
            ..:.|.:..:.|...||:|....|:.|.        :::..|:.         :||        |
Yeast   850 EAVHILLDEIDDYKAATSYCNDVYQSDSTKGEELLLYLYSKLVS---------IYD--------S 897

  Fly   752 QVNREVALEILNTHATRIDPFEIFEHLPDDMPMPQLEKYLEKSIRKMMADKHEMQMMCGFLEAES 816
            ..|.::.|..|..|.::::..||:::||.|:.:..:.:.:.:.::|..:...|.::....|:.|.
Yeast   898 NRNSKLILNFLQDHGSKLNSAEIYKNLPQDISLYDIGRVVSQLLKKHTSKMDETRLEKALLQVEL 962

  Fly   817 TRLENALEEQRNISFELNESSVCSECKK---RFQTQSA--FVRYPNGHIVHLSC 865
            ......|.|:.:....|::|..|..|||   .|.|.|.  |.|.....|.|.:|
Yeast   963 VATTYKLNERMSSYGVLSDSHKCPICKKVISNFGTDSISWFTREGRNIITHYNC 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps39	NP_650702.1	CNH	24..304	CDD:295303	70/379 (18%)
		Vps39_1	464..564	CDD:287352	37/111 (33%)
		Vps39_2	759..868	CDD:287353	28/112 (25%)
VAM6	NP_010206.1	Vps39_1	603..715	CDD:371008	37/111 (33%)
		Vps39_2	905..1016	CDD:402126	27/110 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345371
Domainoid	1	1.000	61	1.000	Domainoid score	I2527
eggNOG	1	0.900	-	-		E1_KOG2063
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004929
OrthoInspector	1	1.000	-	-		oto100222
orthoMCL	1	0.900	-	-		OOG6_102524
Panther	1	1.100	-	-	O	PTHR12894
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1627
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.770