DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps39 and AT1G22860

DIOPT Version :9

Sequence 1:	NP_650702.1	Gene:	Vps39 / 42192	FlyBaseID:	FBgn0038593	Length:	876	Species:	Drosophila melanogaster
Sequence 2:	NP_001319063.1	Gene:	AT1G22860 / 838891	AraportID:	AT1G22860	Length:	984	Species:	Arabidopsis thaliana

Alignment Length:	995	Identity:	213/995 - (21%)
Similarity:	355/995 - (35%)	Gaps:	218/995 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VILGTRSGQLIMYSVDEETGVDMRMFNKNFSRKPITQMEVIASE---------NLLFVLTDLQVQ 82
            |.|||.||.||:.|:|..|....|:.:.:.|..|:..:.|:..|         ..||:|..|..|
plant    37 VYLGTYSGSLILLSLDTLTNTVSRLASVSLSPSPVESIFVLGEERGRVLALCNGYLFLLDSLLSQ 101

  Fly    83 VCD------------IRRIESNFAFMHSAPDTKGCTLFTMDVDTPKSTT---------GRVATVI 126
            ...            .:|:...        |:....|...::.|..|::         |.:.:.:
plant   102 PAKRLGGLLKGINVIAKRVRGR--------DSSSTDLLPSEISTDSSSSKKFLQLLGAGNLVSDV 158

  Fly   127 R---------------VCCAIRRRLVFF----FWKEDKLNSLELIIELSDVP--RTLCWVGHAVC 170
            |               ...||..|::..    ..||....|..::.|:..:.  :||.|:
plant   159 RGNDSRHERVQQGHYVFAVAIGERMLLIELQCAEKEGLSGSFVVLKEILGIGGIKTLVWL----- 218

  Fly   171 VGFKDEYVV------YDISGKAPKKHNLFLTSSSISRDPCICLI-RNNMLGISKDSYLVVVDPSQ 228
                |:||:      |.:.........:..|...:|..|.:.|: :...:.:..|:..||||.:
plant   219 ----DDYVIAGTVKGYSLISCVTGLSGVIFTLPDVSGPPLLKLLCKEWKVLLLVDNVGVVVDTN- 278

  Fly   229 YKESDGINNSTDVRPAAMDSNSSLTPLLWSSPLLDLVWDEPFAVGRVNNAIEVRSL------VGK 287
               ...|..|...| ...||...|      |..|..|.|....:.:..:...|:|:      .|.
plant   279 ---GQPIGGSLVFR-RRPDSVGEL------SFYLVTVGDGKMEIHQKKSGACVQSVSFGPQGCGP 333

  Fly   288 DTLVQTIPELQKTKFLVHADKGTIFAAAT-SELWCIRMVEIPIQRQQLLQQKKFQLAIELTQISD 351
            ..|...           .|..|.:....| |:|...|.|....|.:.||::|:::..|.|.:..|
plant   334 SLLAAD-----------EAGDGNLLVVTTLSKLIFYRRVPYEEQIKDLLRKKRYRETISLVEELD 387

  Fly   352 EPAADRAQTIRQIHMLYAKELFTNKEFSAAMKEFEKA-AIDPYDV---IRLFPN----------- 401
            .........:..:|......|..:..|..|:.:|.|: .::|.:|   |...||
plant   388 SQGEISKDMLSFLHAQIGYLLLFDLRFEEAVNQFLKSEKMEPSEVFPFIMRDPNRWSLVVPRNRY 452

  Fly   402 --LVPEPKPGTEDVT--------------VPTSSTPALED--SD-------LENAYLALIEYLAW 441
              |.|.|.| .|||.              .....||..|:  ||       |::|...:..||..
plant   453 WGLHPPPAP-FEDVVDNGLMAIQRANFLRKAGMDTPVDEEFFSDPPSRADLLDSAIKNITRYLEI 516

  Fly   442 ARQREVVKLRDTKSSSKSLLEIIDTTLLKCYLQTNDSLVAPLLRL----NQCHLEESEKTLKKHN 502
            :|:         |..:..:.|.|||.|:..|...|  .|..:..|    |.|.:||.|..|.:..
plant   517 SRE---------KGLTLPVREGIDTLLMLLYRALN--RVEDMENLASSGNNCVVEELETLLTESG 570

  Fly   503 KISELIILYQMKGKHKEALKLLR-EQASIEGSVLQGRKRTIRYLQE-----LGGDHL-------- 553
            .:..|..||..||...:||.:.| ...:....:.|.....:.||.:     |.|...
plant   571 HLRTLAFLYATKGMGAKALAIWRLFTKNYSSGLWQDSDDLVPYLHDNELIRLSGKEAAAAEAARI 635

  Fly   554 -------PLIFEFADWVLNDNPEEGLTIFTDELIEVESLPRAKVLDFFISKHKALVIPYLEHVIT 611
                   .|..:...|:.:.||...:.:.|.:. ..|.|...:|:.....|...::..|.:.:|.
plant   636 LEEPCDPELALQHLSWIADVNPLFAIQVLTSDK-RTEELSPEQVIQAIDPKKVEIIQRYFQWLIE 699

  Fly   612 EWKDGNTLLH-NVLLKQYREKVQRLLAQ---QE----KGEEVPEL---------IPMRAKLYKML 659
            |....:..|| :..|...|..::.:..|   ||    .|.|..:.         :.:|.:|...|
plant   700 ERDYTDPQLHTSYALSLARSALECVEVQNGIQEADVPNGSEAHDSNVGSISLFEVDVRERLQAFL 764

  Fly   660 EESNDYSPDRLLEEFPTNILLEERALILGRLKKHDNVLSIYIHVLGDVAKATAYAEAHYKEDKHI 724
            :.|:.|.|:.:||....:.|..|:|::..|:.|...||.|....|.|.|.|..|.....:.|  .
plant   765 QSSDLYDPEEILELVEGSELWLEKAILYRRIGKETLVLQILALKLEDCAAAEQYCVEIGRPD--A 827

  Fly   725 FHTLIKCILIPPT--QPLYDGVPLHPDFSQVNREVALEILNTHATRIDPFEIFEHLPDDMPMPQL 787
            |..|:...|.|..  :|::              :.|:.:|:.|...:||.::.:.|..|||:...
plant   828 FMQLLDMYLDPQNGKEPMF--------------KAAVRLLHNHGESLDPLQVLDKLSPDMPLKLA 878

  Fly   788 EKYLEKSIRKMMADKHEMQMMCGFLEAESTRLENALEEQRNISFELNESSVCSECKKRFQTQSAF 852
            ...:.:.:|..:....:.|::.....|.......|..|:|:...::|:.|:|..|..|..|: .|
plant   879 SDTILRMLRARVHHHRQGQIVHNISRALDVDSRLARLEERSRHMQINDESLCDSCYARLGTK-LF 942

  Fly   853 VRYPNGHIVHLSCHDRLARA 872
            ..||:..||...|:.||..:
plant   943 AMYPDDTIVCYKCYRRLGES 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps39	NP_650702.1	CNH	24..304	CDD:295303	65/340 (19%)
		Vps39_1	464..564	CDD:287352	29/124 (23%)
		Vps39_2	759..868	CDD:287353	26/108 (24%)
AT1G22860	NP_001319063.1	Clathrin	<757..837	CDD:306985	24/81 (30%)
AT1G22860	NP_001319063.1	Vps39_2	850..958	CDD:313569	26/108 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	49	1.000	Domainoid score	I4455
eggNOG	1	0.900	-	-		E1_KOG2063
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54136
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12894
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920