DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps39 and EMB2754

DIOPT Version :9

Sequence 1:	NP_650702.1	Gene:	Vps39 / 42192	FlyBaseID:	FBgn0038593	Length:	876	Species:	Drosophila melanogaster
Sequence 2:	NP_195381.6	Gene:	EMB2754 / 829815	AraportID:	AT4G36630	Length:	1000	Species:	Arabidopsis thaliana

Alignment Length:	1064	Identity:	256/1064 - (24%)
Similarity:	411/1064 - (38%)	Gaps:	283/1064 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHQAYSVHSILKQ-GVQIESIAAYGNHVILGTRSGQLIMYSVDEETGVDMRMFNK---------- 54
            :|.||....:||. ..:|:::.:||:.:..|...|.|.:||..|.:..|....::
plant     2 VHNAYDSFQLLKDCPARIDAVESYGSKLFAGCYDGSLRIYSPPESSASDPSELHQETYVLEKTVA 66

  Fly    55 NFSRKPITQMEVIASENLLFVLTDLQVQVCDIRRIESNFAFMHSAPD---------TKGCTLFTM 110
            .||:|||..|||:||..||..|::             :.|| |..|:         .||...::.
plant    67 GFSKKPIVAMEVLASRELLLSLSE-------------SIAF-HGLPNLETVAVITKAKGANAYSW 117

  Fly   111 DVDTPKSTTGRVATVIRVCCAIRRRLVFFFWKEDKLNSLELIIELSD--VP---RTLCWVGHAVC 170
            |     ...|       ..|..|::.|..| |.|....   .:|:.|  ||   :::.|.|..:|
plant   118 D-----DRRG-------FLCFSRQKRVCVF-KHDGGGG---FVEVRDYGVPDTVKSISWCGENIC 166

  Fly   171 VGFKDEYVVYDI----------SGKAPKKHNLFLTSSSISRDPCICLIRNNMLGISKDSYLVVVD 225
            :|.|.|||:.:.          ||:......:.|.|..:            :||
plant   167 LGIKKEYVILNTANGTLSEVFPSGRVAPPLVISLPSGEL------------ILG----------- 208

  Fly   226 PSQYKESDGINNSTDVRPAAMDSNSSLTP---LLWSSPLLDLVWDEPFAVGRVNNAIEVRSLVGK 287
                ||:.|:         .:|.|..|..   :.||.....:|...|:|:..:...:|||.|...
plant   209 ----KENIGV---------FVDQNGKLLQTERICWSEAPTSIVIQNPYAIALLPRRVEVRLLRSP 260

  Fly   288 DTLVQTIPELQKTKFLVHADKGTIFAAATSELWCIRMVEIPIQRQQLLQQKKFQLAIELTQI--S 350
            ..|:||| .||..:.||.::...|.....| ::.:..|.|..|..||.....|:.|:.|.::  .
plant   261 YPLIQTI-VLQNIRRLVKSNNAVIVGLDNS-VYVLFPVSIGAQIVQLTASGNFEEALALCKVLPP 323

  Fly   351 DEPAADRAQTIRQIHMLYAKELFTNKEFSAAMKEFEKAAIDPYDVIRLFPN-------LVPEP-- 406
            ||.:. ||.....||..:|..||.|..:..||:.|..:.:|...|:.::|:       ::|:|
plant   324 DESSL-RAAKESSIHTRFAHYLFENGSYEEAMEHFLASQVDITHVLSMYPSIILPKTTIIPQPDK 387

  Fly   407 --------------KPGTEDVTVPTSSTPALE---DSDLE------NAYLALIEYLAWARQREVV 448
                          ..|..|....:|....||   ::|||      |..:|||:||...|...:.
plant   388 MVDISGDEASLSRGSSGISDDMESSSPRYFLESEDNADLESKKMSHNTLMALIKYLLKRRPAVIE 452

  Fly   449 K-------------------LRDTKSSSKS---------------LLEIIDTTLLKCYLQTNDSL 479
            |                   ..|:..|.||               :..|:||.||:..|.|..|.
plant   453 KATSEGTEEVISDAVGKTYGANDSSKSKKSSKGRGMIPLNSGAREMAAILDTALLQALLHTGQSG 517

  Fly   480 VA-PLLR-LNQCHLEESEKTLKKHNKISELIILYQMKGKHKEALKLLRE--------QASIEGSV 534
            .| .||: :|...::..|:.|.|....|.|:.|::....|.||||||.:        |:..:.:.
plant   518 AAIELLKGVNYSDVKICEEILMKSKNYSALLELFKSNSMHHEALKLLNQLADESKTNQSQTDVTQ 582

  Fly   535 LQGRKRTIRYLQELGGDHLPLIFEFADWVLNDNPEEGLTIFTDELIEVESLPRAKVLDFFISKHK 599
            :...:..|.||:.|......|:.|::..||...|.:.:.:|....|.      |.:::.::.:|
plant   583 IFSPELIIEYLKPLCRTDPMLVLEYSMLVLESCPTQTIDLFLSGNIS------ADLVNSYLKQH- 640

  Fly   600 ALVIP-----YLEHVITEWKD----GNTLLHNVLLKQYREKVQRLLA---QQEKGEEVPELIPMR 652
               .|     ||| ::....|    ||  |.|.:::.|..:|..|.|   .|:|.:| .:..|.|
plant   641 ---APNMQGRYLE-LMMAMNDTAVSGN--LQNEMVQIYLSEVLDLYAAKSAQQKWDE-KDHPPER 698

  Fly   653 AKLYKMLEESNDYSPDRLLEEFPTNILLEERALILGRLKKHDNVLSIYIHVLGDVAKATAYAEAH 717
            .||...||..:.|||..||:..|.:.|.||||:|||::.:|:..||||:|.|.....|.||.:..
plant   699 KKLLSALESISGYSPQPLLKRLPRDALYEERAVILGKMNQHELALSIYVHKLHAPDLALAYCDRI 763

  Fly   718 Y---------KEDKHIFHTLIKCILIP--------------------PTQPLYDGV--------- 744
            |         |...:|:.|:::..|.|                    .|..:.|.|
plant   764 YESVTYLPSGKPSSNIYLTVLQIYLNPKKSAKDFAKRIVALGSFESSDTTKMMDSVLSSKAKGGR 828

  Fly   745 --------------------------------PLHPDFSQVNREVALEILNTHATRIDPFEIFEH 777
                                            ||....|.|.....|::|:....||:..:..:.
plant   829 SKKIVAIEGAEDMRVGLSSSTDSGRSDVDTEEPLEEGDSTVMISEVLDLLSQRWERINGAQALKL 893

  Fly   778 LPDDMPMPQLEKYLEKSIRKMMADKHEMQMMCGFLEAESTRLENALEEQRNISFELNESSVCSEC 842
            ||.:..:..|..:|...:|..........::....::|:.:::..|.:.|....::...|:||.|
plant   894 LPRETKLHNLLPFLAPLLRNSSEAHRNFSVIKSLRQSENLQVKEELYKHRKGVAQVTSESMCSLC 958

  Fly   843 KKRFQTQSAFVRYPNGH-IVHLSC 865
            .|:..| |.|..||||. :||..|
plant   959 NKKIGT-SVFAVYPNGKTLVHFVC 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps39	NP_650702.1	CNH	24..304	CDD:295303	74/316 (23%)
		Vps39_1	464..564	CDD:287352	31/109 (28%)
		Vps39_2	759..868	CDD:287353	27/108 (25%)
EMB2754	NP_195381.6	CNH	69..273	CDD:413319	65/270 (24%)
		Vps39_1	502..612	CDD:371008	31/109 (28%)
		Clathrin	632..759	CDD:395512	45/134 (34%)
		Vps39_2	875..984	CDD:402126	27/108 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2063
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41025
Inparanoid	1	1.050	209	1.000	Inparanoid score	I1262
OMA	1	1.010	-	-		QHG54136
OrthoDB	1	1.010	-	-		D291710at2759
OrthoFinder	1	1.000	-	-		FOG0004929
OrthoInspector	1	1.000	-	-		oto3060
orthoMCL	1	0.900	-	-		OOG6_102524
Panther	1	1.100	-	-	O	PTHR12894
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4596
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840