Protein Alignment Vps39 and Tgfbrap1

DIOPT Version :10

• Sequence 1: NP_650702.1
• Gene: Vps39 / 42192
• FlyBaseID: FBgn0038593
• Length: 876
• Species: Drosophila melanogaster
• Sequence 2: XP_006496363.1
• Gene: Tgfbrap1 / 73122
• MGIID: 2447427
• Length: 869
• Species: Mus musculus
• Alignment Length: 895
• Identity: 213/895 - (23%)
• Similarity: 385/895 - (43%)
• Gaps: 120/895 - (13%)

  Fly    15 VQIESIAAYGNHVILGTRSGQLIMYSVDEE---TGVDMRMFNKNFSR-----KPITQMEVIASEN 71
            :.||.:...|.::.:||....:..:.::|:   ||....:..|...|     ||:.::...::.|
Mouse    34 ISIECVECCGRNLYVGTNDCFIYHFLLEEKAMPTGTATFVATKQLHRHLGFKKPVNELCAASALN 98

  Fly    72 LLFVLTDLQVQVCDIRRIESNFAFMHSAPDTKGCTLFTMDVDTPKSTTGRVATVIRVC-CAIRRR 135
            .|.||.|..:.:.::..:|.    :.|....||.|.|.::    :|........:.|| .:::||
Mouse    99 RLLVLCDNSITLVNMLNLEP----VPSGARIKGATTFAVN----ESPVNGDPFCVEVCIISVKRR 155

  Fly   136 LV-FFFWKEDKLNSLELIIELS--DVPRTLCWVGHAVCVGFKDEYVVYDISGKAPKKHNLFLTSS 197
            .| .|...||:   ::::.|:|  :.|..:...|:.:|:....:|::.:.|  .....:||...|
Mouse   156 TVQMFLVYEDR---VQIVKEVSTPEQPLAVAVDGYFLCLALTTQYIILNYS--TGLSQDLFPYCS 215

  Fly   198 SISRDPCICLIRNNMLGISKDSYLVVVDPSQYKESDGINNSTDVRPAAMDSNSSLTPLLWSSPLL 262
            . .:.|.:       ..|.:..:| :..|.      |:...     |.:...|...|:.||..::
Mouse   216 E-EKPPIV-------KRIGRQEFL-LAGPG------GLGMF-----ATVAGISQRAPVHWSENVI 260

  Fly   263 DLVWDEPFAVGRVNNAIEVRSLVGKDTLVQTIPELQKTKFLVHADKGTIFAAATSELWCIRMVEI 327
            ......|:.:...:..|.|.|::.:.. .||:|  .|...::...:|.:..|.:..::.  :|.:
Mouse   261 GAAVCFPYVIALDDEFITVHSMLDQQQ-KQTLP--FKEGHILQDFEGRVIVATSKGVYI--LVPL 320

  Fly   328 PIQR--QQLLQQKKFQLAIELTQISDEPAADRAQTIRQIHMLYAKEL-------FTNKEFSAAMK 383
            |:::  |.||..::.:.|:.|.:     .|.|.....:..::|.:.|       |...:|..|.:
Mouse   321 PLEKQIQDLLANRRVEEALVLAK-----GARRNIPKEKFQVMYRRILQQAGFIQFAQLQFLEAKE 380

  Fly   384 EFEKAAIDPYDVIRLFPNLVPEPKPGTEDVTVPTSSTPALEDSDLENAYLALIEYLAWARQREVV 448
            .|..:.:|..::|.|:|.|:|.....|.      |..|..|.:||........|.:|..::..:.
Mouse   381 LFRSSQLDVRELISLYPFLLPTSSSFTR------SHPPLHEYADLNQLTQGDQEKMAKCKRFLMS 439

  Fly   449 KLRDTKSS--SKSLLEIIDTTLLKCYLQT-NDSLVAPLLRLNQCHLEESEKTLKKHNKISELIIL 510
            .|.:.:|:  :....|.|||.|||.|.:. :|||:..|:..|.|.|.:|...|:||.|...|.:|
Mouse   440 YLNEIRSTEVANGYKEDIDTALLKLYAEADHDSLLDLLVTENFCLLTDSAAWLEKHKKYFALGLL 504

  Fly   511 YQMKGKHKEALKLLREQASIEGSVLQGRKRTIRYLQELGGDHL------PLIFEFADWVLNDNPE 569
            |....:...|::|   ..:|....:|...|:..|  |...|.|      .|::..|||:|..:.|
Mouse   505 YHYNKQDASAVQL---WVNIVNGDIQDSTRSDLY--EYIVDFLTYCLDQELVWTHADWLLQKSEE 564

  Fly   570 EGLTIFT----DELIEVESLPRAKVLDFFIS---KHKALVIPYLEHVITEWKDGNTLLHNVLLKQ 627
            .|:.|||    ||..:....|     |..||   |:...::.||||::.:.:......|..|...
Mouse   565 IGVQIFTKRPLDEQQQTSFNP-----DNIISSLKKYPKALVKYLEHLVIDRRLQKEEYHTHLAIL 624

  Fly   628 YREKVQRLLAQQEKGEEVPELIPMRAKLYKMLEESNDYSPDRLLEEFPTNILLEERALILGRLKK 692
            |.|:|.|  .:...|.:..|....:|||.::|::|:.|....|.|:.....|..|.|::.|:|.:
Mouse   625 YLEEVLR--QRVSTGGKDVEATETQAKLRRLLQKSDLYRVHLLKEKVQGAGLPMESAILHGKLGE 687

  Fly   693 HDNVLSIYIHVLGDVAKATAYAEAHYKED-----KHIFHTLIKCILI--PPTQPLYDGVPLHPDF 750
            |:..|.|.:|.:||.:.|..|.....:..     :.:||||:...|.  |..|.|
Mouse   688 HEKALHILVHEMGDFSAAEDYCLWSSEGQGAACRQRLFHTLLAMYLRAGPSAQDL---------- 742

  Fly   751 SQVNREVALEILNTHATRIDPFEIFEHLPDDMPMPQLEKYLEKSIRKMMADKHEMQMMCGFLEAE 815
                ...|:::||.||...|..::.:.|||...:..|..:|..::|..:..:...|:..|..::|
Mouse   743 ----TVAAVDLLNHHAREFDVTQVLQLLPDTWSVQLLCPFLMGAMRDSIHARRTTQVALGLAKSE 803

  Fly   816 STRLENALEEQRNISFELNESSVCSECKKRFQTQSAFVRYPNGHIVHLSC 865
            :........:.:..:..|:|..:|..|:..| .:..|||||||.:||..|
Mouse   804 NLIYMYDKMKLKGNAVRLSERELCQLCQNPF-GEPVFVRYPNGGLVHTHC 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps39	NP_650702.1	CNH	24..304	CDD:470577	58/291 (20%)
		Vps39_1	464..564	CDD:371008	35/106 (33%)
		Vps39_2	759..868	CDD:402126	29/107 (27%)
Tgfbrap1	XP_006496363.1	CNH	43..292	CDD:470577	56/282 (20%)
		Vps39_1	457..559	CDD:371008	35/106 (33%)
		Clathrin	594..708	CDD:459884	33/115 (29%)
		Vps39_2	747..855	CDD:402126	29/107 (27%)