Protein Alignment Vps39 and vps39

DIOPT Version :10

• Sequence 1: NP_650702.1
• Gene: Vps39 / 42192
• FlyBaseID: FBgn0038593
• Length: 876
• Species: Drosophila melanogaster
• Sequence 2: NP_001107012.2
• Gene: vps39 / 567078
• ZFINID: ZDB-GENE-080530-2
• Length: 875
• Species: Danio rerio
• Alignment Length: 918
• Identity: 317/918 - (34%)
• Similarity: 491/918 - (53%)
• Gaps: 99/918 - (10%)

  Fly     1 MHQAYSVHSIL-KQGVQIESIAAYGNHVILGTRSGQLIMYSVDEETG-----VDMRMFNKNFSRK 59
            ||.||....|| |..:||:.:||:.:.:::||:.|.|:.|.:.::.|     |.:...|||||:|
Zfish     1 MHDAYEPVPILEKLPLQIDCLAAWDDWLLVGTKPGHLLQYRIKKDAGTNRFEVTLEKSNKNFSKK 65

  Fly    60 PITQMEVIASENLLFVLTDLQVQVCDIRRIESNFAFMHSAPDTKGCTLFTMDVDTPKSTTGRVAT 124
             |.|:.|::...:|..|.:..:.|.|:    ..|..:......||.|||..|:...:|...:
Zfish    66 -IQQLFVVSQYKILVSLLENNIHVHDL----LTFQQITVVSKAKGATLFACDLQQSESGEAK--- 122

  Fly   125 VIRVCCAIRRRLVFFFWKEDKLNSLELIIELSDVPRTLCWVGHAVCVGFKDEYVVYDISGKAPKK 189
             :|:|.|::|::..::||:.:.:.|:..:...|:|:::.|..:::|||||.:|.:..:.|:...|
Zfish   123 -LRMCVAVKRKIQLYYWKDREFHELQGDVTAPDIPKSMAWCENSICVGFKRDYYLIRMDGRGSIK 186

  Fly   190 HNLFLTSSSISRDPCICLIRNNMLGISKDSYLVVVDPSQYKESDGINNSTDVRPAAMDSNSSLTP 254
             .||.|...:  :|.:..:.:....:.:|...||::...........|.||: |.||:.
Zfish   187 -ELFPTGKQL--EPLVAPLADGKAAVGQDDLTVVLNEEGVCTQKCALNWTDI-PVAMEH------ 241

  Fly   255 LLWSSPLLDLVWDEPFAVGRVNNAIEVRSLVGKDTLVQTIPELQKTKFLVHADKGTIFAAATSEL 319
                        ..|:.:..:...:|:|: |....|||:: |||:.:|:..|....::.|:...:
Zfish   242 ------------QPPYIIAVLPRYVEIRT-VEPRLLVQSV-ELQRPRFITSAGSNVVYVASNHFV 292

  Fly   320 WCIRMVEIPIQRQQLLQQKKFQLAIELTQISDEPAADRAQTIRQIHMLYAKELFTNKEFSAAMKE 384
            |.:..|.|..|.:||||.|:|:||::|.::.|:...|:.|.|..|..|:|..||..|.|..:|:.
Zfish   293 WRLVPVSIASQIRQLLQDKQFELALQLAKMKDDFDTDKRQQIHHIQNLFAFNLFCQKRFDDSMQG 357

  Fly   385 FEKAAIDPYDVIRLFPNLVPE--------PKPGTEDVTVPTSSTPALEDSDLENAYLALIEYLAW 441
            |.|...||..||.|:|:|:|.        |.|           .|.|..::||.|:||||:||..
Zfish   358 FAKLGTDPTHVIGLYPDLLPSDYRKQLHYPNP-----------LPPLSGAELEKAHLALIDYLTQ 411

  Fly   442 ARQREVVKLRD--------------TKSSSKSLLEIIDTTLLKCYLQTNDSLVAPLLRL--NQCH 490
            .|...|.:|.|              |..|.|.||:|||||||||||.||.:||:|||||  |.||
Zfish   412 KRSHLVKQLNDSDPSTTSPLMEGTPTIKSRKKLLQIIDTTLLKCYLHTNVALVSPLLRLENNHCH 476

  Fly   491 LEESEKTLKKHNKISELIILYQMKGKHKEALKLLREQASIEGSVLQGRKRTIRYLQELGGDHLPL 555
            :||||..|||.:|.|||||||:.||.|::||::|.:|::...|.|:|.:||::|||.||.::|.:
Zfish   477 IEESEYVLKKAHKYSELIILYEKKGLHQKALQVLLDQSTKANSPLKGHERTVQYLQRLGLENLGI 541

  Fly   556 IFEFADWVLNDNPEEGLTIFTDELIEVESLPRAKVLDFFISKHKALVIPYLEHVITEWKDGNTLL 620
            ||||:.|||...||:||.|||::|.|||:|||.:||:|.....|.|.||||||:|..|.:.....
Zfish   542 IFEFSPWVLKICPEDGLKIFTEDLTEVETLPRDQVLNFLKEGFKELAIPYLEHIIHMWDETRPEF 606

  Fly   621 HNVLLKQYREKVQRLL---------------AQQEKGEEVPELIPMRAKLYKMLEESNDYSPDRL 670
            ||||::.|.||||.|:               |.:|||    ||...|.||...||.|:.|.|:.|
Zfish   607 HNVLIQLYLEKVQGLMKAYLNTLPEGIPAVAAGKEKG----ELGEFRNKLLSFLEVSSSYEPEIL 667

  Fly   671 LEEFPTNILLEERALILGRLKKHDNVLSIYIHVLGDVAKATAYAEAHY----KEDKHIFHTLIKC 731
            :.:||.:.|||||||:|||:.||:..|.||:|:|.|...|..|...||    ..:|.::.:|::.
Zfish   668 ISDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHGHYDPATNGNKDVYLSLLRM 732

  Fly   732 ILIPPTQPLYDGVPLHPDFSQVNREVALEILNTHATRIDPFEIFEHLPDDMPMPQLEKYLEKSIR 796
            .|.||.......:.:.....|.|.:.||.:|..|.::::..:....||.:..:.:::.:||..:.
Zfish   733 YLSPPDVHFLGPIKMELCEPQANLQAALNVLQLHHSKLNTTKAINLLPANTQIREIQVFLESVLE 797

  Fly   797 KMMADKHEMQMMCGFLEAESTRLENALEEQRNISFELNESSVCSECKKRFQTQSAFVRYPNGHIV 861
            :....|...|::...|:||..|::......:.:...:.:...|..|||:. ..|||.|||||.:|
Zfish   798 EKAGRKRFDQVLKSLLQAEFLRVQEERIFHQQVKCVITDEKTCRVCKKKI-GNSAFARYPNGVVV 861

  Fly   862 H-LSCHDR 868
            | ..|.||
Zfish   862 HYFCCKDR 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps39	NP_650702.1	CNH	24..304	CDD:470577	70/284 (25%)
		Vps39_1	464..564	CDD:371008	60/101 (59%)
		Vps39_2	759..868	CDD:402126	28/109 (26%)
vps39	NP_001107012.2	CNH	24..278	CDD:470577	70/286 (24%)
		Vps39_1	448..550	CDD:371008	60/101 (59%)
		Clathrin	579..734	CDD:459884	62/158 (39%)
		Vps39_2	760..868	CDD:402126	28/108 (26%)