DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps39 and tgfbrap1

DIOPT Version :9

Sequence 1:	NP_650702.1	Gene:	Vps39 / 42192	FlyBaseID:	FBgn0038593	Length:	876	Species:	Drosophila melanogaster
Sequence 2:	NP_001077023.1	Gene:	tgfbrap1 / 565026	ZFINID:	ZDB-GENE-070410-66	Length:	863	Species:	Danio rerio

Alignment Length:	904	Identity:	222/904 - (24%)
Similarity:	386/904 - (42%)	Gaps:	130/904 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KQGVQIESIAAYGNHVILGTRSGQLIMYSVDEETGVD-------MRMFNKNFS-RKPITQMEVIA 68
            |..:.||.|...|.|:.|||....:..:.::|.|...       .::.:|... :||:.:::..:
Zfish    21 KVRINIECIECCGQHLYLGTNDCFIHHFLLEEHTTAKGKLAFNAQKLLHKYLGLKKPVVELKAAS 85

  Fly    69 SENLLFVLTDLQVQVCDIRRIESNFAFMHSAPDTKGCTLFTMDVDTPKSTTGRVATV-IRVCCAI 132
            :...|.||.|..:.|.|:..:|   .........||.|.|.:: :.|  .||....| :.|..|.
Zfish    86 ALERLIVLCDSAITVVDMVTLE---PVPTGGAKLKGVTAFCIN-ENP--VTGDAFCVEMAVVLAR 144

  Fly   133 RRRLVFFFWKEDKLNSLELIIELSDVPRTLCWVGHAVCVGFKDEYVVYDISGKAPKKHNLFLTSS 197
            ||.:......||::..|: .:...:.|..|...|:.:|:....:|::.:.|           |.:
Zfish   145 RRAVQICTVHEDRVQMLK-EVTTPEQPCALSLDGYNICLALSTQYMILNYS-----------TGA 197

  Fly   198 SISRDPCICLIRNNML-GISKDSYLVVVDP--SQYKESDGINNSTDVRPAAMDSNSSLTPLLWSS 259
            |....|..|..|..:: .|.::.:|:....  ..:..::||              |...|:.||.
Zfish   198 SQDLFPYDCEERKPIVKRIGREEFLLAAPGGLGMFANAEGI--------------SQRAPVSWSE 248

  Fly   260 PLLDLVWDEPFAVGRVNNAIEVRSLVGKDTLVQTIPELQKTKF----LVHADKGTIFAAATSELW 320
            .::......|:.|......:.|.|::.:. |.||:      .|    |:...:|.:..|::..::
Zfish   249 NVIAAAVCFPYVVALDEGFVTVHSMLDQQ-LKQTL------SFRDGQLLQDFEGKVVVASSKAVY 306

  Fly   321 CIRMVEIPIQR--QQLLQQKKFQLAIELTQISDEPAADRAQTIRQIHMLYAKEL-------FTNK 376
              .:|.:|::|  |.||...:.:.|:.||:     ||.|.....:..:|:.:.|       |...
Zfish   307 --MLVPLPLERQIQDLLASHRVEEALTLTE-----AAQRNIPKEKYQILHRRILQQAGFIQFGQL 364

  Fly   377 EFSAAMKEFEKAAIDPYDVIRLFPNLVPEPKPGTEDVTVPTSSTPALEDSDLENAYLALIEYLAW 441
            :|..|.:.|.|..:|..::|.|:|.|:|.....|.      ...|..|.:||        .:|..
Zfish   365 QFLEAKEHFRKGQLDVRELISLYPLLLPASSSFTR------CHPPLHEFADL--------NHLTQ 415

  Fly   442 ARQREVVK--------LRDTKSS--SKSLLEIIDTTLLKCYLQT-NDSLVAPLLRLNQCHLEESE 495
            ..|.:|.:        |.:.:||  :....|.:||.|||.|.:| ::||:..|...|.|.|.:|.
Zfish   416 GDQEKVQRFKRFLISYLHEVRSSDIANGFHEDVDTALLKLYAETSHESLLDLLASENACLLADSA 480

  Fly   496 KTLKKHNKISELIILYQMKGKHKEALKLLREQASIEGSVLQGRKR--TIRYLQELGG--DHLPLI 556
            ..|:||:|...|.:||...|:...||::   ...|....||...|  ...|:.:...  .:|.|:
Zfish   481 PWLEKHHKYYALGLLYHYNGQDAAALQM---WVKIVNGDLQDSTRPDLFEYVVDFLSFCSNLDLV 542

  Fly   557 FEFADWVLNDNPEEGLTIFTDELIEVESLPRAKVLDF--FISKHKALVIPYLEHVITEWKDGNTL 619
            :..|||.|..:.:.|:.|||......|...:....|.  ::.||...::.||||::.|.|.....
Zfish   543 WRHADWALQKDQKIGVQIFTKRPTSEERRGQLNADDVITYLQKHSQALLLYLEHLVLEKKLQKEK 607

  Fly   620 LHNVLLKQYREKVQRLLAQQEKGEEVPELIPMRAKLYKMLEESNDYSPDRLLEEF-PTNILLEER 683
            .|..|...|.|||..|:::....||  :|...|.||.::|:|||.|....||.:. .:.:||.||
Zfish   608 YHTHLAVLYAEKVLGLISRPSTSEE--QLSAARQKLQRLLKESNLYRVQLLLGKIQDSELLLLER 670

  Fly   684 ALILGRLKKHDNVLSIYIHVLGDVAKATAYA-------EAHYKEDKHIFHTLIKCILIPPTQPLY 741
            |.:.|:|::||..|.:.:|.|.|.:.|..|.       ::.|::  ::||.|:...|.|..
Zfish   671 ATLHGKLEEHDKALHVLVHQLKDSSAAEEYCSWASASQDSSYRQ--NLFHQLLSVYLDPDV---- 729

  Fly   742 DGVPLHPDFSQVNREVALEILNTHATRIDPFEIFEHLPDDMPMPQLEKYLEKSIRKMMADKHEMQ 806
                  |..:|.  ..|:::||.||...|...:.:.||:|..:|.|..:|..::|..:..:...|
Zfish   730 ------PGGAQT--VAAVDLLNRHAEVFDAVRVLKLLPEDWSLPLLRPFLCGAMRATVHARCTSQ 786

  Fly   807 MMCGFLEAESTRLENALEEQRNISFELNESSVCSECKKRFQTQSAFVRYPNGHIVHLSC 865
            :..|...|::.:|.:...:.|.....::|...|..|...| ::......|.|..||::|
Zfish   787 VALGLARAQNLQLLHDRLKYRGGPVLVSEKKGCQLCHNTF-SEPDCACLPGGTPVHINC 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps39	NP_650702.1	CNH	24..304	CDD:295303	59/295 (20%)
		Vps39_1	464..564	CDD:287352	34/104 (33%)
		Vps39_2	759..868	CDD:287353	26/107 (24%)
tgfbrap1	NP_001077023.1	CNH	33..292	CDD:295303	60/297 (20%)
		DUF3887	315..>374	CDD:289772	15/63 (24%)
		Glycosyltransferase_GTB_type	<381..473	CDD:299143	27/105 (26%)
		Clathrin	428..533	CDD:279031	33/107 (31%)
		Vps39_1	448..550	CDD:287352	34/104 (33%)
		CHCR	564..729		51/168 (30%)
		Vps39_2	739..847	CDD:287353	26/107 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2063
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54136
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1627
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850