DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps39 and Vps39

DIOPT Version :9

Sequence 1:	NP_650702.1	Gene:	Vps39 / 42192	FlyBaseID:	FBgn0038593	Length:	876	Species:	Drosophila melanogaster
Sequence 2:	XP_006234844.1	Gene:	Vps39 / 362199	RGDID:	1304858	Length:	886	Species:	Rattus norvegicus

Alignment Length:	924	Identity:	332/924 - (35%)
Similarity:	500/924 - (54%)	Gaps:	106/924 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHQAYSVHSIL-KQGVQIESIAAYGNHVILGTRSGQLIMYSV----------DEETG------VD 48
            ||.|:....|| |..:||:.:||:...:::||:.|.|::|.:          ..|:|      |.
  Rat     1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVT 65

  Fly    49 MRMFNKNFSRKPITQMEVIASENLLFVLTDLQVQVCDIRRIESNFAFMHSAPDTKGCTLFTMDVD 113
            :...|||||:| |.|:.|::...:|..|.:..:.|.|:    ..|..:.:....||.:|||.|:.
  Rat    66 LEKSNKNFSKK-IQQIHVVSQFKILVSLLENNIYVHDL----LTFQQITTVSKAKGASLFTCDLQ 125

  Fly   114 TPKSTTGRVATVIRVCCAIRRRLVFFFWKEDKLNSLELIIELSDVPRTLCWVGHAVCVGFKDEYV 178
              .:.||.  .|:|:|.|:|::|..:|||:.:.:.|:....:.|||:::.|..:::|||||.:|.
  Rat   126 --HTETGE--EVLRMCVAVRKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYY 186

  Fly   179 VYDISGKAPKKHNLFLTSSSISRDPCICLIRNNMLGISKDSYLVVVDPSQYKESDGINNSTDVRP 243
            :..:..|...| .||.|...:  :|.:..:.:..:.:.:|...||::...........|.||: |
  Rat   187 LIRVDAKGSIK-ELFPTGKQL--EPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDI-P 247

  Fly   244 AAMDSNSSLTPLLWSSPLLDLVWDEPFAVGRVNNAIEVRSLVGKDTLVQTIPELQKTKFLVHADK 308
            .||:.                  ..|:.|..:...:|:|:|..: .|||:| |||:.:|:.....
  Rat   248 VAMEH------------------QPPYIVAVLPRYVEIRTLEPR-LLVQSI-ELQRPRFITSGGS 292

  Fly   309 GTIFAAATSELWCIRMVEIPI--QRQQLLQQKKFQLAIELTQISDEPAADRAQTIRQIHMLYAKE 371
            ..|:.|:...:|  |::.:|:  |.|||||.|:|:||::|.::.|:..:::.|.|..|..|||..
  Rat   293 NIIYVASNHFVW--RLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFN 355

  Fly   372 LFTNKEFSAAMKEFEKAAIDPYDVIRLFPNLVPE--------PKPGTEDVTVPTSSTPALEDSDL 428
            ||..|.|..:|:.|.|...||..|:.|:|:|:|.        |.|           .|.|..::|
  Rat   356 LFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNP-----------LPTLSGAEL 409

  Fly   429 ENAYLALIEYLAWARQREVVKLRD---------------TKSSSKSLLEIIDTTLLKCYLQTNDS 478
            |.|:||||:||...|.:.|.||.|               |..|.:.||:|||||||||||.||.:
  Rat   410 EKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKQKLLQIIDTTLLKCYLHTNVA 474

  Fly   479 LVAPLLRL--NQCHLEESEKTLKKHNKISELIILYQMKGKHKEALKLLREQASIEGSVLQGRKRT 541
            ||||||||  |.||:||||..|||.:|.|||||||:.||.|::||::|.:|:....|.|:|.:||
  Rat   475 LVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERT 539

  Fly   542 IRYLQELGGDHLPLIFEFADWVLNDNPEEGLTIFTDELIEVESLPRAKVLDFFISKHKALVIPYL 606
            ::|||.||.::|.|||.::.|||.|.||:||.|||::|.|||||||.:||:|.|...|||.||||
  Rat   540 VQYLQHLGTENLHLIFSYSIWVLRDFPEDGLKIFTEDLPEVESLPRDRVLNFLIENFKALAIPYL 604

  Fly   607 EHVITEWKDGNTLLHNVLLKQYREKVQRLL-----------AQQEKGEEVPELIPMRAKLYKMLE 660
            ||:|..|::..|..||.|::.|.||||.|:           :....|||..||...|.||...||
  Rat   605 EHIIHVWEETGTRFHNCLIQLYCEKVQNLMKDYLLSLPTGKSPVPAGEEAGELGESRQKLLTFLE 669

  Fly   661 ESNDYSPDRLLEEFPTNILLEERALILGRLKKHDNVLSIYIHVLGDVAKATAYAEAHYKEDKH-- 723
            .|:.|.|.||:.:||.:.|||||||:|||:.||:..|.||:|||.|...|..|...||.::|.
  Rat   670 ISSSYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHVLKDTKMAKEYCHKHYDQNKEGN 734

  Fly   724 --IFHTLIKCILIPPTQPLYDGVPLHPDFSQVNREVALEILNTHATRIDPFEIFEHLPDDMPMPQ 786
              ::.:|::..|.||:......:.|.....|.|.:.||::|..|.:::|..:....||.:..:..
  Rat   735 KDVYLSLLRMYLSPPSIHCLGPIKLELLEPQANLQAALQVLELHYSKLDTTKAINLLPANTQIND 799

  Fly   787 LEKYLEKSIRKMMADKHEMQMMCGFLEAESTRLENALEEQRNISFELNESSVCSECKKRFQTQSA 851
            :..:|||.:.:....|...|::...|.||..|::......:.:...:.|..||..|||:. ..||
  Rat   800 IRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKI-GNSA 863

  Fly   852 FVRYPNGHIVHLSC 865
            |.|||||.:||..|
  Rat   864 FARYPNGVVVHYFC 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps39	NP_650702.1	CNH	24..304	CDD:295303	78/295 (26%)
		Vps39_1	464..564	CDD:287352	60/101 (59%)
		Vps39_2	759..868	CDD:287353	32/107 (30%)
Vps39	XP_006234844.1	CNH	20..291	CDD:295303	72/286 (25%)
		Vps39_1	460..562	CDD:287352	62/103 (60%)
		CLH	595..746	CDD:128594	67/165 (41%)
		Clathrin	599..746	CDD:279031	66/161 (41%)
		Vps39_2	772..879	CDD:287353	28/94 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349397
Domainoid	1	1.000	156	1.000	Domainoid score	I4099
eggNOG	1	0.900	-	-		E1_KOG2063
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41025
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1239
OMA	1	1.010	-	-		QHG54136
OrthoDB	1	1.010	-	-		D210614at33208
OrthoFinder	1	1.000	-	-		FOG0004929
OrthoInspector	1	1.000	-	-		oto98498
orthoMCL	1	0.900	-	-		OOG6_102524
Panther	1	1.100	-	-	LDO	PTHR12894
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4596
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810