DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps39 and Tgfbrap1

DIOPT Version :9

Sequence 1:	NP_650702.1	Gene:	Vps39 / 42192	FlyBaseID:	FBgn0038593	Length:	876	Species:	Drosophila melanogaster
Sequence 2:	NP_001100377.2	Gene:	Tgfbrap1 / 301373	RGDID:	1310772	Length:	902	Species:	Rattus norvegicus

Alignment Length:	895	Identity:	214/895 - (23%)
Similarity:	390/895 - (43%)	Gaps:	120/895 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VQIESIAAYGNHVILGTRSGQLIMYSVDEE---TGVDMRMFNKNFSR-----KPITQMEVIASEN 71
            :.||.:...|.::.:||....:..:.::|:   ||....:..|...|     ||:.::...::.|
  Rat    67 ISIECVECCGRNLYVGTNDCFIYHFLLEEKAMPTGTATFIATKQLHRHLGFKKPVNELCAASALN 131

  Fly    72 LLFVLTDLQVQVCDIRRIESNFAFMHSAPDTKGCTLFTMDVDTPKSTTGRVATVIRVC-CAIRRR 135
            .|.||.|..:.:.::..:|.    :.|....||.|.|.::    ::........:.|| .:::||
  Rat   132 RLLVLCDNSITLVNMLNLEP----VPSGARIKGATTFAVN----ENPVNGDPFCVEVCIISVKRR 188

  Fly   136 LV-FFFWKEDKLNSLELIIELS--DVPRTLCWVGHAVCVGFKDEYVVYDISGKAPKKHNLFLTSS 197
            .| .|...||:   ::::.|:|  :.|..:...|:.:|:....:|::.:.|  .....:||...|
  Rat   189 TVQMFLVYEDR---VQIVKEVSTTEQPLAVAVDGYFLCLALTTQYIILNYS--TGFSQDLFPYCS 248

  Fly   198 SISRDPCICLIRNNMLGISKDSYLVVVDPSQYKESDGINNSTDVRPAAMDSNSSLTPLLWSSPLL 262
            . .:.|.:       ..|.:..:| :..|.      |:...     |.:...|...|:.||..::
  Rat   249 E-EKPPIV-------KRIGRQEFL-LAGPG------GLGMF-----ATVAGISQRAPVHWSENVI 293

  Fly   263 DLVWDEPFAVGRVNNAIEVRSLVGKDTLVQTIPELQKTKFLVHADKGTIFAAATSELWCIRMVEI 327
            ......|:.:...:..|.|.|::.:.. .||:|  .|...::...:|.:..|.:..::.  :|.:
  Rat   294 GAAVCFPYVIALDDEFITVHSMLDQQQ-KQTLP--FKEGHILQDFEGRVIVATSKGVYI--LVPL 353

  Fly   328 PIQR--QQLLQQKKFQLAIELTQISDEPAADRAQTIRQIHMLYAKEL-------FTNKEFSAAMK 383
            |:::  |.||..::.:.|:.|.:     .|.|.....:..::|.:.|       |...:|..|.:
  Rat   354 PLEKQIQDLLANRRVEEALVLAK-----GARRNIPKEKFQVMYRRILQQAGFIQFAQLQFLEAKE 413

  Fly   384 EFEKAAIDPYDVIRLFPNLVPEPKPGTEDVTVPTSSTPALEDSDLENAYLALIEYLAWARQREVV 448
            .|..:.:|..::|.|:|.|:|.....|.      |..|..|.:||........|.:|..::..:.
  Rat   414 LFRSSQLDVRELISLYPFLLPTSSSFTR------SHPPLHEYADLNQLTQGDQEKMAKCKRFLMS 472

  Fly   449 KLRDTKSS--SKSLLEIIDTTLLKCYLQT-NDSLVAPLLRLNQCHLEESEKTLKKHNKISELIIL 510
            .|.:.:|:  :....|.|||.|||.|.:. :|||:..|:..|.|.|.:|...|:||.|...|.:|
  Rat   473 YLNEIRSTEVANGYKEDIDTALLKLYAEADHDSLLDLLVTENSCLLTDSAAWLEKHKKYFALGLL 537

  Fly   511 YQMKGKHKEALKLLREQASIEGSVLQGRKRTIRYLQELGGDHL------PLIFEFADWVLNDNPE 569
            |....:...|::|   ..:|....:|...|:..|  |...|.|      .|::..|||:|..:.|
  Rat   538 YHYNKQDASAVQL---WVNIVNGDIQDSTRSDLY--EYIVDFLTYCLDQELVWTHADWLLQKSQE 597

  Fly   570 EGLTIFT----DELIEVESLPRAKVLDFFIS---KHKALVIPYLEHVITEWKDGNTLLHNVLLKQ 627
            .|:.:||    ||..:....|     |..||   |:...::.||||::.:.:......|..|...
  Rat   598 VGVQVFTKRPLDEQQQTSFNP-----DDIISCLKKYPKALVKYLEHLVIDRRLQKEEYHTHLALL 657

  Fly   628 YREKVQRLLAQQEKGEEVPELIPMRAKLYKMLEESNDYSPDRLLEEFPTNILLEERALILGRLKK 692
            |.|:|.|..| ...|::| |....:|||.::|::|:.|....|.|:.....|..|.|::.|:|.:
  Rat   658 YLEEVLRQRA-PTGGKDV-EATETQAKLRRLLQKSDLYRVHLLKEKIQGAGLPMESAILHGKLGE 720

  Fly   693 HDNVLSIYIHVLGDVAKATAYA-------EAHYKEDKHIFHTLIKCILIPPTQPLYDGVPLHPDF 750
            |:..|.|.:|.:||.:.|..|.       :|..::  .:||||:       ...|..|...| |.
  Rat   721 HEKALHILVHEMGDFSAAEDYCLWSSEGQDAACRQ--RLFHTLL-------AMYLRAGPSAH-DL 775

  Fly   751 SQVNREVALEILNTHATRIDPFEIFEHLPDDMPMPQLEKYLEKSIRKMMADKHEMQMMCGFLEAE 815
            :    ..|:::||.||...|..::.:.|||...:..|..:|..::|..:..:...|:..|..::|
  Rat   776 T----VAAVDLLNHHAREFDATQVLQLLPDTWSVQLLCPFLTGAMRDSIHARRTTQVALGLAKSE 836

  Fly   816 STRLENALEEQRNISFELNESSVCSECKKRFQTQSAFVRYPNGHIVHLSC 865
            :........:.:..:..|:|..:|..|:..| .:..|||||||.:||..|
  Rat   837 NLIYMYDKMKLKGSAIWLSEKKLCQLCQNPF-GEPVFVRYPNGGLVHTHC 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps39	NP_650702.1	CNH	24..304	CDD:295303	57/291 (20%)
		Vps39_1	464..564	CDD:287352	35/106 (33%)
		Vps39_2	759..868	CDD:287353	29/107 (27%)
Tgfbrap1	NP_001100377.2	CNH	76..325	CDD:413319	55/282 (20%)
		Vps39_1	490..592	CDD:371008	35/106 (33%)
		Clathrin	627..741	CDD:395512	35/115 (30%)
		Vps39_2	780..888	CDD:402126	29/107 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2063
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54136
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820