DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps39 and Vps39

DIOPT Version :9

Sequence 1:	NP_650702.1	Gene:	Vps39 / 42192	FlyBaseID:	FBgn0038593	Length:	876	Species:	Drosophila melanogaster
Sequence 2:	NP_671495.1	Gene:	Vps39 / 269338	MGIID:	2443189	Length:	886	Species:	Mus musculus

Alignment Length:	924	Identity:	333/924 - (36%)
Similarity:	501/924 - (54%)	Gaps:	106/924 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHQAYSVHSIL-KQGVQIESIAAYGNHVILGTRSGQLIMYSV----------DEETG------VD 48
            ||.|:....|| |..:||:.:||:...:::||:.|.|::|.:          ..|:|      |.
Mouse     1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVT 65

  Fly    49 MRMFNKNFSRKPITQMEVIASENLLFVLTDLQVQVCDIRRIESNFAFMHSAPDTKGCTLFTMDVD 113
            :...|||||:| |.|:.|::...:|..|.:..:.|.|:    ..|..:.:....||.:|||.|:.
Mouse    66 LEKSNKNFSKK-IQQIHVVSQFKILVSLLENNIYVHDL----LTFQQITTVSKAKGASLFTCDLQ 125

  Fly   114 TPKSTTGRVATVIRVCCAIRRRLVFFFWKEDKLNSLELIIELSDVPRTLCWVGHAVCVGFKDEYV 178
              .:.||.  .|:|:|.|:|::|..:|||:.:.:.|:....:.|||:::.|..:::|||||.:|.
Mouse   126 --HTETGE--EVLRMCVAVRKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYY 186

  Fly   179 VYDISGKAPKKHNLFLTSSSISRDPCICLIRNNMLGISKDSYLVVVDPSQYKESDGINNSTDVRP 243
            :..:.||...| .||.|...:  :|.:..:.:..:.:.:|...||::...........|.||: |
Mouse   187 LIRVDGKGSIK-ELFPTGKQL--EPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDI-P 247

  Fly   244 AAMDSNSSLTPLLWSSPLLDLVWDEPFAVGRVNNAIEVRSLVGKDTLVQTIPELQKTKFLVHADK 308
            .||:.                  ..|:.|..:...:|:|:|..: .|||:| |||:.:|:.....
Mouse   248 VAMEH------------------QPPYIVAVLPRYVEIRTLEPR-LLVQSI-ELQRPRFITSGGS 292

  Fly   309 GTIFAAATSELWCIRMVEIPI--QRQQLLQQKKFQLAIELTQISDEPAADRAQTIRQIHMLYAKE 371
            ..|:.|:...:|  |::.:|:  |.|||||.|:|:||::|.::.|:..:::.|.|..|..|||..
Mouse   293 NIIYVASNHFVW--RLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFN 355

  Fly   372 LFTNKEFSAAMKEFEKAAIDPYDVIRLFPNLVPE--------PKPGTEDVTVPTSSTPALEDSDL 428
            ||..|.|..:|:.|.|...||..|:.|:|:|:|.        |.|           .|.|..::|
Mouse   356 LFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNP-----------LPTLSGAEL 409

  Fly   429 ENAYLALIEYLAWARQREVVKLRD---------------TKSSSKSLLEIIDTTLLKCYLQTNDS 478
            |.|:||||:||...|.:.|.||.|               |..|.|.||:|||||||||||.||.:
Mouse   410 EKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVA 474

  Fly   479 LVAPLLRL--NQCHLEESEKTLKKHNKISELIILYQMKGKHKEALKLLREQASIEGSVLQGRKRT 541
            ||||||||  |.||:||||..|||.:|.|||||||:.||.|::||::|.:|:....|.|:|.:||
Mouse   475 LVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERT 539

  Fly   542 IRYLQELGGDHLPLIFEFADWVLNDNPEEGLTIFTDELIEVESLPRAKVLDFFISKHKALVIPYL 606
            ::|||.||.::|.|||.::.|||.|.||:||.|||::|.|||||||.:||:|.|...|||.||||
Mouse   540 VQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLNFLIENFKALAIPYL 604

  Fly   607 EHVITEWKDGNTLLHNVLLKQYREKVQRLL-----------AQQEKGEEVPELIPMRAKLYKMLE 660
            ||:|..|::..:..||.|::.|.||||.|:           :....|||..||...|.||...||
Mouse   605 EHIIHVWEETGSQFHNCLIQLYCEKVQSLMKDYLLSLPTGKSPVPAGEEGGELGEYRQKLLMFLE 669

  Fly   661 ESNDYSPDRLLEEFPTNILLEERALILGRLKKHDNVLSIYIHVLGDVAKATAYAEAHYKEDKH-- 723
            .|:.|.|.||:.:||.:.|||||||:|||:.||:..|.||:|||.|...|..|...||.::|.
Mouse   670 ISSHYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHVLKDTKMAKEYCHKHYDQNKEGN 734

  Fly   724 --IFHTLIKCILIPPTQPLYDGVPLHPDFSQVNREVALEILNTHATRIDPFEIFEHLPDDMPMPQ 786
              ::.:|::..|.||:......:.|.....|.|.:.||::|..|.:::|..:....||.:..:..
Mouse   735 KDVYLSLLRMYLSPPSIHCLGPIKLELLEPQANLQAALQVLELHYSKLDTTKAINLLPANTQIND 799

  Fly   787 LEKYLEKSIRKMMADKHEMQMMCGFLEAESTRLENALEEQRNISFELNESSVCSECKKRFQTQSA 851
            :..:|||.:.:....|...|::...|.||..|::......:.:...:.|..||..|||:. ..||
Mouse   800 IRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKI-GNSA 863

  Fly   852 FVRYPNGHIVHLSC 865
            |.|||||.:||..|
Mouse   864 FARYPNGVVVHYFC 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps39	NP_650702.1	CNH	24..304	CDD:295303	79/295 (27%)
		Vps39_1	464..564	CDD:287352	60/101 (59%)
		Vps39_2	759..868	CDD:287353	32/107 (30%)
Vps39	NP_671495.1	CNH	20..291	CDD:382970	73/286 (26%)
		Vps39_1	460..562	CDD:371008	62/103 (60%)
		CHCR	573..750		81/191 (42%)
		Clathrin	<661..746	CDD:391473	35/88 (40%)
		Vps39_2	772..880	CDD:371009	28/94 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845965
Domainoid	1	1.000	153	1.000	Domainoid score	I4283
eggNOG	1	0.900	-	-		E1_KOG2063
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41025
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1270
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54136
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004929
OrthoInspector	1	1.000	-	-		oto95002
orthoMCL	1	0.900	-	-		OOG6_102524
Panther	1	1.100	-	-	LDO	PTHR12894
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1627
SonicParanoid	1	1.000	-	-		X4596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790