DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps39 and vam6

DIOPT Version :9

Sequence 1:	NP_650702.1	Gene:	Vps39 / 42192	FlyBaseID:	FBgn0038593	Length:	876	Species:	Drosophila melanogaster
Sequence 2:	NP_593392.1	Gene:	vam6 / 2541859	PomBaseID:	SPAC23H4.14	Length:	905	Species:	Schizosaccharomyces pombe

Alignment Length:	961	Identity:	216/961 - (22%)
Similarity:	399/961 - (41%)	Gaps:	167/961 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHQAYSVHSILK-QGVQIESIAAYGNHVILGTRSGQLIMYSV---DEETGVDMRMFN----KNFS 57
            ||:|:|::.:|: ...::|.:...|..|.:...:|.|..|.:   :||...|..|.:    .||:
pombe     1 MHRAFSLYRVLELSKARVECVFELGGLVYVSNSNGDLDSYKIYNNEEEEAADFVMEHVDVYPNFT 65

  Fly    58 RKPITQMEVIASENLLFVLTDLQVQVCDIRRIESNFAFMHSAPDTKGCTLFTMDVDTPKSTTGRV 122
            :||||::...|::::.:.|:|.||.|..|...:..|:|   ....:...|:..::
pombe    66 KKPITKVVSCATQDIFYALSDSQVYVYQISTFKKLFSF---GAHCQNMCLYGDEL---------- 117

  Fly   123 ATVIRVCCAIRRRLVFFFWKEDKLNSLELIIELSDVPRTLCWVGHA-VCVGFKDEYVVYDISGKA 186
                 :..:.::.|..:..:::...:|...|.|:|.||:|.||... :.|...:::...:.....
pombe   118 -----IVLSSKKNLEIYEIQKNSKPNLTKTISLNDRPRSLAWVSPTMILVSLSNDFCAVNTETSR 177

  Fly   187 PKKHNL-FLTSSSISRDPCI--CLIRNNML---GISKDSYLVVVDPSQYKESDGINNSTDVRPAA 245
            ....|| :..|||:......  ..|::|.|   .||.|..|:      .|:|.|:  ..:::...
pombe   178 ISSLNLAWQQSSSLGLGISYIGMSIKSNKLHITRISDDEVLL------SKDSQGL--LVNLKSLQ 234

  Fly   246 MDSNSSLTPLLWSSPLLDLVWDEPFAVGRVNNAIEVRSLVGKDT--LVQT--IPELQKTKFLVHA 306
            :..|    ||.|.:....::::.|:.:...|..|.:.:   |:|  ::|.  |..:..| |..|
pombe   235 VSRN----PLRWPTVPQAVIYNSPYIITLHNQYIYIWN---KETYAMIQQIGISNIYST-FSCH- 290

  Fly   307 DKGTIFAAATSELWCIRMVEIPIQRQQLLQQKKFQLAIE-LTQISDEPAADRAQTIRQIHMLYAK 370
             |.|.| .:.|.:|.:...:...|.:.||..:....||. |:||:......|...:|......|.
pombe   291 -KNTFF-TSNSYVWILTPEDFSNQIEALLNTENLNEAISVLSQITVSQFPKRDYYLRITKREKAL 353

  Fly   371 ELFTNKEFSAAMKEFEKAAIDPYDVIRLFPNLV--------------PEPKPGTE-DVTVP---T 417
            ..|::.::..||:.|.:.:..|..|:.|||.|:              |......| :|..|   :
pombe   354 RSFSSGDYDLAMRLFSEISESPSTVLGLFPGLLDNNYSDAISILSMAPSQNESIESNVLFPGNHS 418

  Fly   418 SSTPALEDSDL-----------------------ENAYLALIEYLAWARQREVVKLRDTKSSSKS 459
            :|...|.:.|.                       .|.:|:..|...:.:::.:....|....:|.
pombe   419 NSQTDLRNGDAVSTVANNKRLRSLSTYLTDSRRKANRFLSYDEEHYFLQKKNLFLNADGTLVAKE 483

  Fly   460 LLE----IIDTTLLKCYLQTNDSLVAPLLRL-NQCHLEESEKTLKKHNKISELIILYQMKGKHKE 519
            .||    .|||||...|:.::.:||..|||| |:|.....|..|.......||:..|..|..|:.
pombe   484 KLEKIAVQIDTTLFLIYMISSPALVGSLLRLPNRCETSVVETNLLSAKMYRELVEYYYGKSLHEA 548

  Fly   520 ALKLLRE--QASIEGSVLQGRKRT-------IRYLQELGGDHLPLIFEFADWVLNDNPEEGLTIF 575
            ||.||.:  ....:...|:|:..|       :.||::|..:...|||:::...|:::|:..:.||
pombe   549 ALDLLTKLCDEPTDTLSLKGKSNTTSKYEPILSYLEKLSPELDHLIFKYSRVPLSEDPQNSIVIF 613

  Fly   576 TDELIEVESLPRAKVLDFFISKHKALVIPYLEHVITEWKDGNTLLHNVLLKQYREKVQRLLAQQE 640
            .||..|..::.:..||.:..:....:.|.|||.::.:.|..:|:....|...|   ::|:|..:|
pombe   614 IDENSEASTISKGVVLKYLETISYKVSIIYLEKLLLDNKFNDTVFPTRLALLY---LKRILELEE 675

  Fly   641 ----KGEEVPELIPMRAKLYKMLEESNDYSPDRLLEEFPTNILLEE-----------RALILGRL 690
                |.:||         ..:.:|:..||..:.  :::..|::|:|           ..::..||
pombe   676 TTDFKNQEV---------FKQTIEKLEDYLTNS--KQYDANVVLQEINSQDEFLSTVSIILYRRL 729

  Fly   691 KKHDNVLSIYIHVLGDVAKATAYAEAHYKEDKHIFHTLIKCILIPPTQPLYDGVPLHPDFSQVNR 755
            .:|.:.|.:|:.:|.|...|.:|..:.|..|..             |:|.|   .|..:.|:..:
pombe   730 SRHQDALDVYLKILNDWEGALSYCNSVYSIDGE-------------TEPYY---MLLAEISKNYK 778

  Fly   756 EVALEILN---THATRIDPFEIFEHLPDDMPMPQLEKYLEKSIRKMMADKHEMQMMCGFLEAEST 817
            ..:|.||:   .:::|:|...:|..||.::.|...........|::..:....:......:   .
pombe   779 SGSLNILDFITKYSSRLDLNRVFPLLPKNISMKSYHSLFSSQFRQLFEELSNKETQSKLYQ---K 840

  Fly   818 RLENALEEQRNISFE---LNESSVCSECKKRFQTQSAFVRYPNGHIVHLSC 865
            |||:..||...:..|   :.....|..|.||. .:|....:|:|.:||..|
pombe   841 RLEDLNEELTKVRSEKVVITREKTCLFCHKRL-GKSVISIFPDGSVVHYGC 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps39	NP_650702.1	CNH	24..304	CDD:295303	64/297 (22%)
		Vps39_1	464..564	CDD:287352	34/109 (31%)
		Vps39_2	759..868	CDD:287353	26/113 (23%)
vam6	NP_593392.1	CNH	66..283	CDD:295303	51/249 (20%)
		Vps39_1	492..602	CDD:287352	34/109 (31%)
		Clathrin	643..753	CDD:279031	27/123 (22%)
		Vps39_2	785..893	CDD:287353	24/110 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	43	1.000	Domainoid score	I3654
eggNOG	1	0.900	-	-		E1_KOG2063
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41025
Inparanoid	1	1.050	156	1.000	Inparanoid score	I1271
OMA	1	1.010	-	-		QHG54136
OrthoFinder	1	1.000	-	-		FOG0004929
OrthoInspector	1	1.000	-	-		oto101978
orthoMCL	1	0.900	-	-		OOG6_102524
Panther	1	1.100	-	-	O	PTHR12894
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1627
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.950