DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps39 and vps3

DIOPT Version :9

Sequence 1:	NP_650702.1	Gene:	Vps39 / 42192	FlyBaseID:	FBgn0038593	Length:	876	Species:	Drosophila melanogaster
Sequence 2:	NP_587839.1	Gene:	vps3 / 2539519	PomBaseID:	SPCC364.05	Length:	910	Species:	Schizosaccharomyces pombe

Alignment Length:	983	Identity:	194/983 - (19%)
Similarity:	342/983 - (34%)	Gaps:	256/983 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IESIAAYGNHVILGTRSGQLIMYSVDEETGVDMRMFNKNFSRKPITQMEVIASENLLFVLTDLQV 81
            :.:||.|.||:..||..|.:.:|:...        |..|.|.:.:.::.:::...:..:|....:
pombe    19 VTTIALYNNHLYFGTEGGDVFLYNFSN--------FQLNESPELVKKISLVSKSRVNRILAMPFL 75

  Fly    82 QVCDIRRIESNFAFMHSAPDT---------KGCTLFTMDVDTPKSTTGRVATVIRVCCAIRRRLV 137
            ....|.  ..:||.::...|.         ||...|.    .|.......:|.:.|   ....|.
pombe    76 GAVFIH--HGSFAEVYKEDDLTQLYPSISFKGLVEFC----HPGQRIDEKSTYLIV---TNTHLK 131

  Fly   138 FFFWKEDKLNSLELIIELSDVPRTLCWVGHAVCVGFKDEYVVYDISGKAPKKHNLFLT------- 195
            ...:::|.:..::..::..:: :|....||.||:..::.:.:.||           ||
pombe   132 LISFQKDGIILVKNELKYPNI-QTARVNGHIVCLVTENSFELLDI-----------LTFDTTPLF 184

  Fly   196 --------SSSISRDPCICLIRNNML---GISKDSYLVVVDPSQYKESDG-INNST---DVRPAA 245
                    ::.:...|.|.|..|..|   |..||:..:.||      |.| :..||   ...|..
pombe   185 PIIKYDSENNGLMYKPMIVLHSNEFLLITGSPKDAIGLFVD------SQGNVTRSTLTFSFYPKH 243

  Fly   246 MDSNSSLTPLLWSSPL-------------LDLVWDEPFA-VGRVNNA-IEVRSLVGKDTLVQTI- 294
            :.|.|.....:.||.|             ::|..||.|: :.|:.:. ...|.:..|.:.|.|.
pombe   244 VFSTSHYVFAISSSSLQIIDINTLSLVKSINLKDDESFSFISRLTSVHFCDRQIFSKFSAVNTAS 308

  Fly   295 ----------PELQKTKFLVHADKGTIFAAATSEL------WCIRMVEIPIQR--QQLLQQKKFQ 341
                      ....|..|:...:|...|.|....:      ..|..:|.|::|  ::|...||:
pombe   309 TSKTSDTIERASFSKPSFIFLTNKSWGFGAEAHFMNKLEFSITIGDIEAPLRRVSKRLRNPKKY- 372

  Fly   342 LAIELTQISDEPAADRAQTIRQIHMLYAKELFTNKEFSAAMKEFEKAAIDPYDVIRLFPNLVPEP 406
                  .|:::.|..::..:.||..|   :.:...::..::...|.:.|||..||.|:|:|....
pombe   373 ------GITNDVAYLQSAYLEQISAL---QYWKQGQYENSLSLLETSKIDPRVVISLYPDLYHSE 428

  Fly   407 KPG--------------TEDVTVPT--SSTPALEDSD-----------LENAYLALIEYLAWARQ 444
            ...              :.|.||..  .|.....|:|           .||||:.|:.||...::
pombe   429 LSYIAFQGVISFRKSILSVDDTVANVLKSNELFRDTDQYTQRQMIEITKENAYIMLMRYLKNYKK 493

  Fly   445 REVVKLRDTKSSSKSLLEIIDTTLLKCYLQTNDSLVA------PLLRLNQCHLEESEKTLKKHNK 503
            ...:. ....||.:.::..::.:||..||..:| |.|      .||......:|:.:..|.:..:
pombe   494 NTSIS-EYLLSSQRDVMLAVEHSLLLLYLNMDD-LAAGTKNAKELLESGLTGVEDIKDVLIQKKE 556

  Fly   504 ISELIILYQMKGKHKEALKLLREQASIEGSVLQGRKRTIRYLQELGGDHLPLIF-EFADWVLNDN 567
            ...|.:|......|...|:..::..:.:....:.....|:..:.|..|..|..| ||..|:...:
pombe   557 YYLLSVLLATVRDHDGVLQTWKKLITGDYEDRRFNDGLIKIREYLVNDIEPSTFWEFTTWLCKHD 621

  Fly   568 PEEGLTIFTDELIEVESLPRAKVLDFFISKHKALVIPYLEHVITEWKDGNTLLHNVLLKQ----- 627
            ..||..:..|:.:. .|:....||:...|....::|.||       ...|::.|..||.:
pombe   622 ATEGTRVLLDKTVS-GSISAEDVLEHLDSSQDDVLIDYL-------VKSNSVTHRALLLKLCVNK 678

  Fly   628 -------YREKVQRLLAQQEKGEEVPEL-IPMRAKLYKML------------------------- 659
                   :.:...||....|...|:|.: .|..|:..:.|
pombe   679 LLGSLLDHNDFKNRLETAIETFRELPCMEKPTYAQYLEQLWGDMSDFSTHLSFYYLCSINLMENV 743

  Fly   660 -EESNDYSPDRLLEEFPTNILL--EERALILGRLKKHDNVLSIYIHVLGDVAKATAYAEAHYKED 721
             |||.|...|.|.:....|:.|  :.......|.|.::..||:.:..:.|.....||
pombe   744 EEESIDKIKDILFDIHVDNLYLFPQLEHSFYKRKKNYEKALSVLVTNIHDYKGGEAY-------- 800

  Fly   722 KHIFHTLIKCILIPPTQP------------LYDGVPLHPDFSQVNREVALEILNTHATRIDPFE- 773
                     |:.|....|            ..||.   .||.:       |:|...     ||.
pombe   801 ---------CLQIDDVYPQCWCNLLEKCISTGDGC---SDFIK-------ELLYRR-----PFSY 841

  Fly   774 ----IFEHLPDDMPMPQLEKYLEKSIRKMMADK-HEMQMMCGFLEAESTRLENALEE------QR 827
                :.|.:||...:..|..:| ..::|..|:: :|.|..   |..|.:..:| |||      :|
pombe   842 TLSYVCEQIPDHWNLNLLADFL-CILQKRNAERLNESQTR---LTLEKSLSQN-LEELFMAINRR 901

  Fly   828 NISFELNE 835
            |::...||
pombe   902 NVALGKNE 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps39	NP_650702.1	CNH	24..304	CDD:295303	62/336 (18%)
		Vps39_1	464..564	CDD:287352	23/106 (22%)
		Vps39_2	759..868	CDD:287353	23/89 (26%)
vps3	NP_587839.1	CNH	27..277	CDD:295303	52/284 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2063
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12894
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1627
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940