Protein Alignment Vps39 and VPS39

DIOPT Version :10

• Sequence 1: NP_650702.1
• Gene: Vps39 / 42192
• FlyBaseID: FBgn0038593
• Length: 876
• Species: Drosophila melanogaster
• Sequence 2: XP_011519705.1
• Gene: VPS39 / 23339
• HGNCID: 20593
• Length: 907
• Species: Homo sapiens
• Alignment Length: 904
• Identity: 316/904 - (34%)
• Similarity: 485/904 - (53%)
• Gaps: 105/904 - (11%)

  Fly     1 MHQAYSVHSIL-KQGVQIESIAAYGNHVILGTRSGQLIMYSV----------DEETG------VD 48
            ||.|:....|| |..:||:.:||:...:::||:.|.|::|.:          ..|:|      |.
Human     1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVT 65

  Fly    49 MRMFNKNFSRKPITQMEVIASENLLFVLTDLQVQVCDIRRIESNFAFMHSAPDTKGCTLFTMDVD 113
            :...|||||:| |.|:.|::...:|..|.:..:.|.|:    ..|..:.:....||.:|||.|:.
Human    66 LEKSNKNFSKK-IQQIHVVSQFKILVSLLENNIYVHDL----LTFQQITTVSKAKGASLFTCDLQ 125

  Fly   114 TPKSTTGRVATVIRVCCAIRRRLVFFFWKEDKLNSLELIIELSDVPRTLCWVGHAVCVGFKDEYV 178
              .:.||.  .|:|:|.|::::|..:|||:.:.:.|:....:.|||:::.|..:::|||||.:|.
Human   126 --HTETGE--EVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYY 186

  Fly   179 VYDISGKAPKKHNLFLTSSSISRDPCICLIRNNMLGISKDSYLVVVDPSQYKESDGINNSTDVRP 243
            :..:.||...| .||.|...:  :|.:..:.:..:.:.:|...||::...........|.||: |
Human   187 LIRVDGKGSIK-ELFPTGKQL--EPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDI-P 247

  Fly   244 AAMDSNSSLTPLLWSSPLLDLVWDEPFAVGRVNNAIEVRSLVGKDTLVQTIPELQKTKFLVHADK 308
            .||:.                  ..|:.:..:...:|:|:...: .|||:| |||:.:|:.....
Human   248 VAMEH------------------QPPYIIAVLPRYVEIRTFEPR-LLVQSI-ELQRPRFITSGGS 292

  Fly   309 GTIFAAATSELWCIRMVEIPI--QRQQLLQQKKFQLAIELTQISDEPAADRAQTIRQIHMLYAKE 371
            ..|:.|:...:|  |::.:|:  |.|||||.|:|:||::|.::.|:..:::.|.|..|..|||..
Human   293 NIIYVASNHFVW--RLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFN 355

  Fly   372 LFTNKEFSAAMKEFEKAAIDPYDVIRLFPNLVPE--------PKPGTEDVTVPTSSTPALEDSDL 428
            ||..|.|..:|:.|.|...||..|:.|:|:|:|.        |.|           .|.|..::|
Human   356 LFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNP-----------LPVLSGAEL 409

  Fly   429 ENAYLALIEYLAWARQREVVKLRD---------------TKSSSKSLLEIIDTTLLKCYLQTNDS 478
            |.|:||||:||...|.:.|.||.|               |..|.|.||:|||||||||||.||.:
Human   410 EKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVA 474

  Fly   479 LVAPLLRL--NQCHLEESEKTLKKHNKISELIILYQMKGKHKEALKLLREQASIEGSVLQGRKRT 541
            ||||||||  |.||:||||..|||.:|.|||||||:.||.|::||::|.:|:....|.|:|.:||
Human   475 LVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERT 539

  Fly   542 IRYLQELGGDHLPLIFEFADWVLNDNPEEGLTIFTDELIEVESLPRAKVLDFFISKHKALVIPYL 606
            ::|||.||.::|.|||.::.|||.|.||:||.|||::|.|||||||.:||.|.|...|.|.||||
Human   540 VQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYL 604

  Fly   607 EHVITEWKDGNTLLHNVLLKQYREKVQRLLAQQ-----------EKGEEVPELIPMRAKLYKMLE 660
            ||:|..|::..:..||.|::.|.||||.|:.:.           ..|||..||...|.||...||
Human   605 EHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLE 669

  Fly   661 ESNDYSPDRLLEEFPTNILLEERALILGRLKKHDNVLSIYIHVLGDVAKATAYAEAHYKE----D 721
            .|:.|.|.||:.:||.:.|||||||:|||:.||:..|.||:|:|.|...|..|...||..    :
Human   670 ISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGN 734

  Fly   722 KHIFHTLIKCILIPPTQPLYDGVPLHPDFSQVNREVALEILNTHATRIDPFEIFEHLPDDMPMPQ 786
            |.::.:|::..|.||:......:.|.....:.|.:.||::|..|.:::|..:....||.:..:..
Human   735 KDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQIND 799

  Fly   787 LEKYLEKSIRKMMADKHEMQMMCGFLEAESTRLENALEEQRNISFELNESSVCSECKKR 845
            :..:|||.:.:....|...|::...|.||..|::......:.:...:.|..||..|||:
Human   800 IRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKK 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps39	NP_650702.1	CNH	24..304	CDD:470577	76/295 (26%)
		Vps39_1	464..564	CDD:371008	60/101 (59%)
		Vps39_2	759..868	CDD:402126	21/87 (24%)
VPS39	XP_011519705.1	CNH	24..290	CDD:470577	76/298 (26%)
		Vps39_1	460..562	CDD:371008	60/101 (59%)
		Clathrin	595..746	CDD:459884	60/150 (40%)
		Vps39_2	772..862	CDD:402126	21/87 (24%)