DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps39 and vps-39

DIOPT Version :9

Sequence 1:	NP_650702.1	Gene:	Vps39 / 42192	FlyBaseID:	FBgn0038593	Length:	876	Species:	Drosophila melanogaster
Sequence 2:	NP_001041164.1	Gene:	vps-39 / 179902	WormBaseID:	WBGene00011625	Length:	926	Species:	Caenorhabditis elegans

Alignment Length:	975	Identity:	279/975 - (28%)
Similarity:	453/975 - (46%)	Gaps:	165/975 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHQAYSVHSI-LKQGVQIESIA-AYGNHVIL-GTRSGQLIMYSVD-EETGVDMRMFNKNFSRKPI 61
            |:.||:...: |:..|::..:| ...|..:| |.|:|.|..|::. ...|.::....|:|.:|.:
Worm     1 MYDAYTPCEVALRLPVEVTCLAFQESNQTLLAGGRAGHLYAYTISANRRGFELTNICKSFHKKAV 65

  Fly    62 TQMEVIASENLLFVLTDLQVQVCDIRRIESNFAFMHSAPDTKGCTLF-------TMDVDTPKSTT 119
            .:::|...|:||..::|.|:           .|...|.|:.|..||.       |....:|| |:
Worm    66 MELKVCQREDLLLCVSDGQL-----------MAHKLSDPEYKVETLIHKVKPVQTFARFSPK-TS 118

  Fly   120 GRVATVIRVCCAIRRRLVFFFW--KEDKLNSLELIIELS----DVPRTLCWVGHAVCVGFKDEYV 178
            |.:..::    :.|::|..|.|  |:.....:|:.::.:    |.|.::..||..|....::||.
Worm   119 GDLYVIV----SSRKKLYLFKWGEKDGHKEFIEVALDYNPVFLDTPTSIRCVGEMVFFSVRNEYF 179

  Fly   179 VYDI----------SGKAPKKHNLFLTS-SSISRDPCIC-LIRNNMLGISKDSYLVVVDPSQYKE 231
            ...:          .|..|:..|.|:|. .:.:..|.|. :|....:...::..:|
Worm   180 SMTMQKDKTTTSPSEGSTPEGWNGFVTRLLNFNCQPGIVPMIDRRRVAFVRNEIVV--------- 235

  Fly   232 SDGINNSTDV---RPAAMDSNSSLTPLLWSSPLLDLVWDEPFAVGRVNNA-IEVRSLVGKDTLVQ 292
                  :||:   |||.:.|:.    ..:|...:.:|:|.|:.||.::.. :||||:. ...|||
Worm   236 ------TTDIWGQRPANVLSDE----YKFSEVPMQIVYDSPYLVGMLSKGRVEVRSIF-DGQLVQ 289

  Fly   293 TIPELQKTKFLVHADKGTIFAAATSELWCIRMVE-IPIQRQQLLQQKKFQLAIELTQISDEPAAD 356
            |: .|.|...|....:|.:|.||.|::|.:...: :......|:|::.|:|||:|.:.|:..|.:
Worm   290 TM-SLPKAMTLCSGARGQVFVAALSDIWILDTSQNLRKNVSHLIQERHFELAIQLAENSNLFAEE 353

  Fly   357 RAQTIRQIHMLYAKELFTNKEFSAAMKEFEKAAIDPYDV---IRLFPNLVPEPKPGTEDVTVPTS 418
            :...|::   ..|..||..|:|..:...|.:...|..:|   ||:||.|:|:   |.:.:|...|
Worm   354 QKLEIKK---KAALNLFNQKKFDESFALFGEIKTDISEVLSIIRMFPELLPD---GFQSMTGVVS 412

  Fly   419 STPALEDSDLENAYLALIEYLAWARQRE--------------VVKLRDTKSSSKSL--LEIIDTT 467
            ..||   :|...|.|||..||:..|...              ..|..|....:|.|  |.::|||
Worm   413 DMPA---NDRMRALLALGSYLSEIRTEHAKHIELYNRLYSSGAAKKTDEDEKAKLLLTLRVVDTT 474

  Fly   468 LLKCYLQTNDSLVAPLLRL--NQCHLEESEKTLKKHNKISELIILYQMKGKHKEALKLLREQAS- 529
            |||||::|...||..|:||  |.|..|:::|.|:...::..|.|||:.:.||:.||.|..:|:|
Worm   475 LLKCYIKTKPMLVDSLIRLQSNACTFEDAKKILESEGRLRSLFILYETRKKHEMALDLFIDQSSR 539

  Fly   530 ------IEGSVLQGRKRTIRYLQELGGDHLPLIFEFADWVLNDNPEEGLTIFT-DELIEVESLPR 587
                  .:.::.|    .:.|||.||..:||||.::|.|||..|.|.|:.||| ||.....:|.|
Worm   540 PDADPFFDDAIQQ----IVEYLQSLGNSNLPLILKYAKWVLAKNLEAGVQIFTSDETEMARNLNR 600

  Fly   588 AKVLDFFISKHKALVIPYLEHVITEWKDGNTLLHNVLLKQYREKVQRLLAQ-------------- 638
            ..|::|..|:....:||||||||.:|::.::..|..||:.|..:|..|...
Worm   601 KAVVEFLKSECPDALIPYLEHVIFKWEEPSSYFHETLLEFYVARVNTLFKDYVHAFPDAFSDENI 665

  Fly   639 QEKGEEVPELIPMRAKLYKMLEESNDYSPDRLLEEFPTNILLEERALILGRLKKHDNVLSIYIHV 703
            ...|:|..||...|.:|.|.||.|:.|||..:|.:...:...|||||||||||:|:..|:||::.
Worm   666 TRAGDEDGELGLYRKRLLKFLEVSHSYSPQTVLLQLAPHAFYEERALILGRLKQHEQALAIYVNT 730

  Fly   704 LGDVAKATAYA----EAHYKEDKHIFHTLIKCILIPPTQPLYDGVPLHPDFS------------- 751
            |.:|..|..|.    .||.:.:..::..|.:.::.|..|.|: .:|.|.|.:
Worm   731 LKNVPAAEEYCRLYYNAHDETNSQVYLMLFRTLVHPNQQQLH-SIPYHADSTPFGSYRDDVSEAS 794

  Fly   752 ---------QVNREVALEILNTHATRIDPFEIFEHLPDDMPM----PQLEKYLEKSIRKMMADKH 803
                     |.:...|::||..||.:||.......||...|:    ..:...::.:.|:....|.
Worm   795 TLVNSTSSYQPDVNTAIKILAKHADKIDTVGALNMLPATTPLRVVFSAINAVIQTTGRQASTRKM 859

  Fly   804 EMQM-MCGFLEAESTRLENALEEQRNISFELNESSVCSECKKRFQTQSAFVRYPNGHIVHLSCHD 867
            |..: .|    |.|.:||...:.| :....:|.||.|..|:|:... |||||||:|.:.||.||:
Worm   860 EKSVSQC----AMSKKLERKNKAQ-STKIIVNFSSECVVCEKKIAV-SAFVRYPDGRLAHLYCHN 918

Fly 868 867
Worm 919 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps39	NP_650702.1	CNH	24..304	CDD:295303	72/310 (23%)
		Vps39_1	464..564	CDD:287352	42/108 (39%)
		Vps39_2	759..868	CDD:287353	36/114 (32%)
vps-39	NP_001041164.1	CNH	21..303	CDD:307087	74/318 (23%)
		Vps39_1	471..576	CDD:313568	42/108 (39%)
		Vps39_2	811..919	CDD:313569	36/114 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164089
Domainoid	1	1.000	106	1.000	Domainoid score	I4113
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41025
Inparanoid	1	1.050	290	1.000	Inparanoid score	I1695
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54136
OrthoDB	1	1.010	-	-		D210614at33208
OrthoFinder	1	1.000	-	-		FOG0004929
OrthoInspector	1	1.000	-	-		oto17592
orthoMCL	1	0.900	-	-		OOG6_102524
Panther	1	1.100	-	-	LDO	PTHR12894
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1627
SonicParanoid	1	1.000	-	-		X4596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940