DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps39 and tgfbrap1

DIOPT Version :9

Sequence 1:	NP_650702.1	Gene:	Vps39 / 42192	FlyBaseID:	FBgn0038593	Length:	876	Species:	Drosophila melanogaster
Sequence 2:	XP_002941202.2	Gene:	tgfbrap1 / 100497663	XenbaseID:	XB-GENE-1009020	Length:	869	Species:	Xenopus tropicalis

Alignment Length:	929	Identity:	218/929 - (23%)
Similarity:	384/929 - (41%)	Gaps:	175/929 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QGVQIESIAAYGNHVILGTRSGQLIMY-------------SVDEETGVDMRMFNKNFSR------ 58
            ||:.||.:...|:.:.|||  ...::|             |:.::|......|.....|
Frog    19 QGIHIECLECSGHDLYLGT--SDCVIYHLLLVEQQLSEPTSLVQQTDQPCTSFTTTQQRQRQLGL 81

  Fly    59 -KPITQMEVIASENLLFVLTDLQVQVCDIRRIESNFAFMHSAPDTKGCTLFTMDVDTPKSTTGRV 122
             |||.::...::.:.|.||.|..:.:.....:|.     ..||..:|...||:: :.|.|  |..
Frog    82 KKPICELRAASALSRLLVLCDNTISILCSESLEP-----LPAPKIRGVLTFTLN-ENPVS--GDP 138

  Fly   123 ATVIRVCCAIRRRLVFFFWKEDKLNSLELIIELSDVPRTLCWV---GHAVCVGFKDEYVVYDI-S 183
            .:|.....:.::|.|..|....:  .::||.|:: .|...|.:   |..:|:.....|:..:. :
Frog   139 FSVELCLISSKKRTVQIFSVGQE--RVQLIREVA-TPEQACVIAADGLYLCLALSSRYITLNYNT 200

  Fly   184 GKAPKKHNLFLTSSSISRDPCICLIRNNMLGISKDSYLVVVDPS---QYKESDGINNSTDVRPAA 245
            |..   .:||...|. .:.|.:       ..||:..:| :..||   .:....||.....||
Frog   201 GHC---QDLFPYPSD-QKKPIV-------KWISRQEFL-LAGPSGLGMFATVAGITQRAPVR--- 250

  Fly   246 MDSNSSLTPLLWSSPLLDLVWDEPFAVGRVNNAIEVRSLVGKDTLVQTIPELQKTKFLVHADKGT 310
                       ||..::......|:.:......|.|.|::.:.. .||:|  .|...::...:|.
Frog   251 -----------WSDNVIGAAISFPYVLALDEEFITVHSMLDQQK-KQTLP--FKEGIILQDFEGR 301

  Fly   311 IFAAATSELWCIRMVEIPIQR--QQLLQQKKFQLAIELTQISDEPAADRAQTIRQIHMLYAKEL- 372
            :..|:.:.::.  ::.:|:::  |.||..::.:.|:.|.:     .|.|.....:..::|.:.|
Frog   302 VIVASCNGVYV--LIPLPLEKQIQDLLSSQRVEEALALAK-----GARRNIPKEKFQVMYRRILQ 359

  Fly   373 ------FTNKEFSAAMKEFEKAAIDPYDVIRLFPNLVPEPKPGTEDVTVPTSST------PALED 425
                  |...:|..|.:.|..:.:|..::|.|:|            :.:|:||:      |..|.
Frog   360 QAGFIQFAKLQFLEAKELFRSSQLDIRELISLYP------------LMLPSSSSFIRTHPPLHEY 412

  Fly   426 SDLENAYLA-----------LIEYLAWARQREVVKLRDTKSSSKSLLEIIDTTLLKCYLQTN-DS 478
            :||......           |:.||:..|..||         :....|.:||.|||.|.:.| :|
Frog   413 ADLNQLTRGDQEKVNKCKRFLMTYLSEIRSTEV---------ANGYQEDVDTALLKLYAEANHES 468

  Fly   479 LVAPLLRLNQCHLEESEKTLKKHNKISELIILYQMKGKHKEALKLLREQASIEGSVLQGRKR--- 540
            |:..|:..|.|.:.:|...|:||.|...|.:||....:...||::   ...|....|:...|
Frog   469 LLDLLVSENSCEVSDSASWLEKHKKYFALGLLYHYNKQDAAALQI---WVKIINGELEDSTRPDL 530

  Fly   541 ---TIRYLQELGGDHLPLIFEFADWVLNDNPEEGLTIFT----DELIEVESLPRAKVLDFFISKH 598
               .:.:|......|  |::::|||||..:.:.|:.|||    :|..:....| .|::.:....|
Frog   531 FEYVVDFLTFSRDQH--LVWQYADWVLQKSEQVGVRIFTKRSPEEYTQNGFCP-DKIVSYLCKYH 592

  Fly   599 KALVIPYLEHVITEWKDGNTLLHNVLLKQYREKVQRLLAQQEKGEEVPELIPMRAKLYKMLEESN 663
            |||:: :|||::.|........|..|...|.|:||||.|......|..|:  .|.:|..:|.:|:
Frog   593 KALLL-FLEHLVLEKMLQKEKYHTHLAVLYVEEVQRLNAMDSPDIEQVEM--QRGRLQNLLRQSD 654

  Fly   664 DYSPDRLLEEFPTNILLEERALILGRLKKHDNVLSIYIHVLGDVAKATAYA-------EAHYKED 721
            .|....|:::.....|..|||::.|:|::|...|.|.:|.|.:.|.|..|.       :..|::
Frog   655 LYRVHLLIDKIKGTDLHMERAILHGKLEEHGQALDILVHHLKNFAAAENYCVWNSEGRDTPYRQ- 718

  Fly   722 KHIFHTLIKCILIPPTQPLYDGVPLHPDFSQVNREVALEILNTHATRIDPFEIFEHLPDDMPMPQ 786
             |:|..|:...|   |...:|...|         ..|:::||.|....|...:...||::..:..
Frog   719 -HLFQLLLSSYL---TFASHDNSFL---------VAAVDLLNNHPAEFDAASVLRLLPENWSVQL 770

  Fly   787 LEKYLEKSIRKMMADKHEMQMMCGFLEAESTRLENALEEQRNISFE-----LNESSVCSECKKRF 846
            |..:|..::|:.:......|:..|..:|     ||.:.:|..::..     |::...||.|:..|
Frog   771 LSPFLAGAMREHVHALRMSQITIGLAKA-----ENVVYKQEKLNLREKPIVLSDKKYCSVCRNPF 830

  Fly   847 QTQSAFVRYPNGHIVHLSC 865
            | :..|||||:|.|||..|
Frog   831 Q-EPVFVRYPSGQIVHTHC 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps39	NP_650702.1	CNH	24..304	CDD:295303	61/306 (20%)
		Vps39_1	464..564	CDD:287352	31/106 (29%)
		Vps39_2	759..868	CDD:287353	31/112 (28%)
tgfbrap1	XP_002941202.2	CNH	93..288	CDD:413319	47/232 (20%)
		Vps39_1	453..555	CDD:371008	31/106 (29%)
		Clathrin	610..706	CDD:421262	31/97 (32%)
		Vps39_2	743..849	CDD:402126	31/112 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10846
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000