Protein Alignment CG18599 and NKX2-1

DIOPT Version :10

• Sequence 1: NP_650701.1
• Gene: CG18599 / 42191
• FlyBaseID: FBgn0038592
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: NP_001073136.1
• Gene: NKX2-1 / 7080
• HGNCID: 11825
• Length: 401
• Species: Homo sapiens
• Alignment Length: 241
• Identity: 65/241 - (26%)
• Similarity: 97/241 - (40%)
• Gaps: 48/241 - (19%)

  Fly   222 NGGSNSGNNNSSPSVNNFNCDSVAGNGRYLHGGHQHPHPHQAGFAAVAAAVGAAP----SALQSL 282
            ||  |.||.:..|...:...:|.:|.|.|  |.:..|.     |.|::..:|.|.    |.:..|
Human   118 NG--NLGNMSELPPYQDTMRNSASGPGWY--GANPDPR-----FPAISRFMGPASGMNMSGMGGL 173

  Fly   283 QQLHQQHHAQQQATLSFQREKLKSDSHKKSALKNKRVRTIFTPEQLECLEAEFERQQYMVGPERL 347
            ..|               .:..|:.:...||.:.|| |.:|:..|:..||..|::|:|:..|||.
Human   174 GSL---------------GDVSKNMAPLPSAPRRKR-RVLFSQAQVYELERRFKQQKYLSAPERE 222

  Fly   348 YLAHTLKLTEAQVKVWFQNRRIKWRKHHLE-LTQQRLALIRQTQLPGTSLLGNQVSVSANAAHSV 411
            :||..:.||..|||:||||.|.|.::...: ..||:|    |....|....|.........|...
Human   223 HLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQL----QQDSGGGGGGGGTGCPQQQQAQQQ 283

  Fly   412 STERT---------NGCSAASP-----SLQEEDNEDSKHSLSLSGA 443
            |..|.         ..|.|.:|     |||....:.::|....:.|
Human   284 SPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQAAQA 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18599	NP_650701.1	Homeodomain	317..373	CDD:459649	26/55 (47%)
NKX2-1	NP_001073136.1	Homeodomain	192..248	CDD:459649	26/56 (46%)