DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18599 and Nkx6-1

DIOPT Version :9

Sequence 1:	NP_650701.1	Gene:	CG18599 / 42191	FlyBaseID:	FBgn0038592	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_113925.1	Gene:	Nkx6-1 / 65193	RGDID:	69318	Length:	365	Species:	Rattus norvegicus

Alignment Length:	394	Identity:	102/394 - (25%)
Similarity:	155/394 - (39%)	Gaps:	103/394 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 HPPTPTTGNNNNNSSSSSNSSS-----HNSNSNHREQLAAAAATATSHAQLIEAAAAHSSLDV-- 167
            :||.||...::::|||||:|.|     ||. ...:...|...::..|..|.:.||..|...|:
  Rat    40 YPPLPTGPPSSSSSSSSSSSPSPPLGAHNP-GGLKPPAAGGLSSLGSPPQQLSAATPHGINDILS 103

  Fly   168 GKSFTIAAILGLQSQRKDYNNAINLSLHDNNNIIGDDNNKCYTSNPNNNNNNNNNGGSNSGNN-- 230
            ..|..:|:...|.|                             ::|:.:::::::..|.:..:
  Rat   104 RPSMPVASGAALPS-----------------------------ASPSGSSSSSSSSASATSASAA 139

  Fly   231 -----------NSSPSVNNFNCDSVAGNGRYLHGGHQHPHPHQAGF-----AAVAAAVGAAPSAL 279
                       .|||:      ..:||..|:   ....|.|...|.     ||..||||..|..|
  Rat   140 AAAAAAAAAAAASSPA------GLLAGLPRF---SSLSPPPPPPGLYFSPSAAAVAAVGRYPKPL 195

  Fly   280 QSLQQLHQQHHAQQQATLSFQREKLKSDSHKKSAL-----KNKRVRTIFTPEQLECLEAEFERQQ 339
            ..|.............:..::..:|....|:.|.|     |.|..|..|:.:|:..||..||:.:
  Rat   196 AELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTK 260

  Fly   340 YMVGPERLYLAHTLKLTEAQVKVWFQNRRIKWRKHHLELTQQRLALIRQTQLPGTSLLGNQVSVS 404
            |:.||||..||::|.:||:||||||||||.||||.|    ...:|..::.|
  Rat   261 YLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKH----AAEMATAKKKQ-------------- 307

  Fly   405 ANAAHSVSTERTNGCSAASPSLQEEDNEDSKHSLSLSGALPPLSRAQSESDLSICNDSLDGDSLM 469
                 ...|||..|.|.     .|||::|      .:..|.|.|..:..:.|...:.|..|..|:
  Rat   308 -----DSETERLKGTSE-----NEEDDDD------YNKPLDPNSDDEKITQLLKKHKSSGGSLLL 356

  Fly   470 DGSE 473
            ..||
  Rat   357 HASE 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18599	NP_650701.1	Homeobox	320..372	CDD:278475	28/51 (55%)
Nkx6-1	NP_113925.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..136		26/125 (21%)
		Repressor domain. /evidence=ECO:0000250	102..269		42/204 (21%)
		Homeobox	240..294	CDD:395001	29/53 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..365		21/100 (21%)
		Involved in DNA-binding. /evidence=ECO:0000250	307..365		19/84 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810