Protein Alignment CG18599 and GBX2

DIOPT Version :10

• Sequence 1: NP_650701.1
• Gene: CG18599 / 42191
• FlyBaseID: FBgn0038592
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: NP_001476.2
• Gene: GBX2 / 2637
• HGNCID: 4186
• Length: 348
• Species: Homo sapiens
• Alignment Length: 292
• Identity: 65/292 - (22%)
• Similarity: 105/292 - (35%)
• Gaps: 83/292 - (28%)

  Fly   100 HTHHQDGHHPHPPTPT-------TGNNNNNSSSSSNSSSHNSNSNHREQLAA---AAATATSHAQ 154
            |.|||     .|..||       .|....::..::.....:::..|:|..||   |.........
Human    78 HPHHQ-----IPSLPTGFCSSLAQGMALTSTLMATLPGGFSASPQHQEAAAARKFAPQPLPGGGN 137

  Fly   155 LIEAAAAHSSLDVGKSF-----TIAAILGLQSQRKDYNNAINLSLHDNNNIIGDDNNK--CYTSN 212
            ..:|.|..:..:.||.|     ::.|....::.:.....|:.....|.:.:..|...|  .::..
Human   138 FDKAEALQADAEDGKGFLAKEGSLLAFSAAETVQASLVGAVRGQGKDESKVEDDPKGKEESFSLE 202

  Fly   213 PNNNNNNNNNGGSNSGNNNSSPSVNNFNCDSVAGNGRYLHGGHQ-HPHPHQAGFAAVAAAVGAAP 276
            .:.:.::::|....:.:....|                   ||. ...|..:|.|....:.|
Human   203 SDVDYSSDDNLTGQAAHKEEDP-------------------GHALEETPPSSGAAGSTTSTG--- 245

  Fly   277 SALQSLQQLHQQHHAQQQATLSFQREKLKSDSHKKSALKNKRVRTIFTPEQLECLEAEFERQQYM 341
                                                  ||:|.||.||.|||..||.||..::|:
Human   246 --------------------------------------KNRRRRTAFTSEQLLELEKEFHCKKYL 272

  Fly   342 VGPERLYLAHTLKLTEAQVKVWFQNRRIKWRK 373
            ...||..:||.|||:|.|||:||||||.||::
Human   273 SLTERSQIAHALKLSEVQVKIWFQNRRAKWKR 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18599	NP_650701.1	Homeodomain	317..373	CDD:459649	32/55 (58%)
GBX2	NP_001476.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..81		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..139		5/27 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..251		14/131 (11%)
		Homeodomain	248..304	CDD:459649	32/55 (58%)