DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18599 and Nkx6-1

DIOPT Version :9

Sequence 1:	NP_650701.1	Gene:	CG18599 / 42191	FlyBaseID:	FBgn0038592	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_659204.1	Gene:	Nkx6-1 / 18096	MGIID:	1206039	Length:	365	Species:	Mus musculus

Alignment Length:	395	Identity:	104/395 - (26%)
Similarity:	156/395 - (39%)	Gaps:	105/395 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 HPPTPTTGNNNNNSSSSSNSS------SHNSNSNHREQLAAAAATATSHAQLIEAAAAHSSLDV- 167
            :||.| ||..:::|||||:||      |||. ...:...|...::..|..|.:.||..|...|:
Mouse    40 YPPLP-TGPPSSSSSSSSSSSPSPPLGSHNP-GGLKPPAAGGLSSLGSPPQQLSAATPHGINDIL 102

  Fly   168 -GKSFTIAAILGLQSQRKDYNNAINLSLHDNNNIIGDDNNKCYTSNPNNNNNNNNNGGSNSGNN- 230
             ..|..:|:...|.|                             ::|:.:::::::..|.:..:
Mouse   103 SRPSMPVASGAALPS-----------------------------ASPSGSSSSSSSSASATSASA 138

  Fly   231 ------------NSSPSVNNFNCDSVAGNGRYLHGGHQHPHPHQAGF-----AAVAAAVGAAPSA 278
                        .|||:      ..:||..|:   ....|.|...|.     ||..||||..|..
Mouse   139 AAAAAAAAAAAAASSPA------GLLAGLPRF---SSLSPPPPPPGLYFSPSAAAVAAVGRYPKP 194

  Fly   279 LQSLQQLHQQHHAQQQATLSFQREKLKSDSHKKSAL-----KNKRVRTIFTPEQLECLEAEFERQ 338
            |..|.............:..::..:|....|:.|.|     |.|..|..|:.:|:..||..||:.
Mouse   195 LAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQT 259

  Fly   339 QYMVGPERLYLAHTLKLTEAQVKVWFQNRRIKWRKHHLELTQQRLALIRQTQLPGTSLLGNQVSV 403
            :|:.||||..||::|.:||:||||||||||.||||.|    ...:|..::.|
Mouse   260 KYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKH----AAEMATAKKKQ------------- 307

  Fly   404 SANAAHSVSTERTNGCSAASPSLQEEDNEDSKHSLSLSGALPPLSRAQSESDLSICNDSLDGDSL 468
                  ...|||..|.|.     .|||::|      .:..|.|.|..:..:.|...:.|..|..|
Mouse   308 ------DSETERLKGTSE-----NEEDDDD------YNKPLDPNSDDEKITQLLKKHKSSGGSLL 355

  Fly   469 MDGSE 473
            :..||
Mouse   356 LHASE 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18599	NP_650701.1	Homeobox	320..372	CDD:278475	28/51 (55%)
Nkx6-1	NP_659204.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..136		28/126 (22%)
		Repressor domain. /evidence=ECO:0000250	102..269		42/204 (21%)
		Homeobox	240..293	CDD:278475	28/52 (54%)
		DUF3381	<291..345	CDD:288694	20/87 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..365		21/100 (21%)
		Involved in DNA-binding. /evidence=ECO:0000250	307..365		19/84 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810