Protein Alignment CG18599 and GSX2

DIOPT Version :10

• Sequence 1: NP_650701.1
• Gene: CG18599 / 42191
• FlyBaseID: FBgn0038592
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: NP_573574.2
• Gene: GSX2 / 170825
• HGNCID: 24959
• Length: 304
• Species: Homo sapiens
• Alignment Length: 445
• Identity: 95/445 - (21%)
• Similarity: 124/445 - (27%)
• Gaps: 226/445 - (50%)

  Fly    12 PLSHFLALHNTQAS-GGGSGG-GSSVAGLGGLGGGIHAHGQPHHAALAAAAAAAVAVSAGQSSY- 73
            ||.....||:::.| |.|||| |:.|.|.||.|              .|.||.|:.:..||.|.
Human    62 PLCVTSHLHSSRGSVGAGSGGAGAGVTGAGGSG--------------VAGAAGALPLLKGQFSSA 112

  Fly    74 --------QMEHQQQHHQLQQQQQQQQHHHHQQLHTHHQDGHHPHPPTPTTGNNNNNSSSSSNSS 130
                    ::.|...||      ...|||||     |||
Human   113 PGDAQFCPRVNHAHHHH------HPPQHHHH-----HHQ-------------------------- 140

  Fly   131 SHNSNSNHREQLAAAAATATSHAQLIEAAAAHSSLDVGKSFTIAAILGLQSQRKDYNNAINLSLH 195
                                                                             
Human   141 ----------------------------------------------------------------- 140

  Fly   196 DNNNIIGDDNNKCYTSNPNNNNNNNNNGGSNSGNNNSSPSVNNFNCDSVAGNGRYLHGGHQHPHP 260
                                                                            |
Human   141 ----------------------------------------------------------------P 141

  Fly   261 HQAGFAAVAAAVGAAPSALQSLQQLHQQHHAQQQATLSFQREKLKSDSHKKSAL----------- 314
            .|.|.||.|||..||.:|..:|.  |.||||......::.    .:|..:...|
Human   142 QQPGSAAAAAAAAAAAAAAAALG--HPQHHAPVCTATTYN----VADPRRFHCLTMGGSDASQVP 200

  Fly   315 KNKRVRTIFTPEQLECLEAEFERQQYMVGPERLYLAHTLKLTEAQVKVWFQNRRIKWRKHHLELT 379
            ..||:||.||..||..||.||....|:....|:.:|..|.|:|.|||:||||||:|.:|......
Human   201 NGKRMRTAFTSTQLLELEREFSSNMYLSRLRRIEIATYLNLSEKQVKIWFQNRRVKHKKEGKGTQ 265

  Fly   380 QQRLALIRQTQLPGTSLLGNQVSVSANAAHSVSTERTNGCSAASPSLQEEDNEDS 434
            :...|        |...:|:||       |...:|..:..|.||.:   :|.|.|
Human   266 RNSHA--------GCKCVGSQV-------HYARSEDEDSLSPASAN---DDKEIS 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18599	NP_650701.1	Homeodomain	317..373	CDD:459649	28/55 (51%)
GSX2	NP_573574.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..151		16/200 (8%)
		Homeodomain	203..259	CDD:459649	28/55 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	283..304		7/23 (30%)