Protein Alignment CG18599 and Hhex

DIOPT Version :10

• Sequence 1: NP_650701.1
• Gene: CG18599 / 42191
• FlyBaseID: FBgn0038592
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: NP_032271.1
• Gene: Hhex / 15242
• MGIID: 96086
• Length: 271
• Species: Mus musculus
• Alignment Length: 213
• Identity: 64/213 - (30%)
• Similarity: 94/213 - (44%)
• Gaps: 46/213 - (21%)

  Fly   251 LHGGHQHPHPHQAGFAAVAAAVGAA---------PSALQSLQQLHQQHHAQQQATL--SFQREKL 304
            :|....| ||    .||:|||.|.:         |..:........:|....:..|  .|.:..|
Mouse    76 VHPAFSH-HP----AAALAAAYGPSGFGGPLYPFPRTVNDYTHALLRHDPLGKPLLWSPFLQRPL 135

  Fly   305 KSDSHKKSALKNKRVRTIFTPEQLECLEAEFERQQYMVGPERLYLAHTLKLTEAQVKVWFQNRRI 369
                ||:   |..:||  |:.:|...||.:||.|:|:..|||..||..|:|:|.|||.||||||.
Mouse   136 ----HKR---KGGQVR--FSNDQTVELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRA 191

  Fly   370 KWRKHHLELTQQRLALIRQTQLPGTSLLGNQVSVSANAAHSVSTERTNGCS------AASPSLQE 428
            |||:    |.|:.....::..|       :.:..|......:.:|:..|.|      :.||:.||
Mouse   192 KWRR----LKQENPQSNKKDAL-------DSLDTSCEQGQDLPSEQNKGASLDRSQCSPSPASQE 245

  Fly   429 ----EDNEDSKHSLSLSG 442
                |.:|||...:.:.|
Mouse   246 DPDSEISEDSDQEVDIEG 263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18599	NP_650701.1	Homeodomain	317..373	CDD:459649	29/55 (53%)
Hhex	NP_032271.1	Interaction with SOX13. /evidence=ECO:0000250|UniProtKB:Q03014	1..138		16/70 (23%)
		Required for WNT signaling induction. /evidence=ECO:0000250|UniProtKB:Q03014	138..271		47/142 (33%)
		Homeodomain	143..195	CDD:459649	29/53 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	195..271		16/80 (20%)