DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18599 and Dlx2

DIOPT Version :9

Sequence 1:	NP_650701.1	Gene:	CG18599 / 42191	FlyBaseID:	FBgn0038592	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_034184.1	Gene:	Dlx2 / 13392	MGIID:	94902	Length:	332	Species:	Mus musculus

Alignment Length:	376	Identity:	85/376 - (22%)
Similarity:	123/376 - (32%)	Gaps:	163/376 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 HHQQL---HTHHQDGHHPHPPTPT-TGNNNNNSSSSSNSSSHNSNSNHREQLAAAAATATSHAQL 155
            |..|:   .|:||   |..||:.. .|...|::|||||||.|....:  ..|..:.||.:|:
Mouse    13 HSTQITASSTYHQ---HQQPPSGAGAGPGGNSNSSSSNSSLHKPQES--PTLPVSTATDSSY--- 69

  Fly   156 IEAAAAHSSLDVGKSFTIAAILGLQSQRKDYNNAINLSLHDNNNIIGDDNNKCYTSNPNNNNNNN 220
                                                                 ||      |..:
Mouse    70 -----------------------------------------------------YT------NQQH 75

  Fly   221 NNGGSNSGNNNSSPSVNNFNCDSVAGNGRYLH-GGHQHPHPHQAGFAAV-------------AAA 271
            ..||   |...:||               |.| |.:|:   |.:|...|             ||.
Mouse    76 PAGG---GGGGASP---------------YAHMGSYQY---HASGLNNVSYSAKSSYDLGYTAAY 119

  Fly   272 VGAAPSALQSLQQLHQQHHAQQQATLSFQREKLKSDSHKKSALKNKRVRTIFTPEQLECLEAEFE 336
            ...||....|....::......:..:.....|.|         |.::.|||::..||..|:..|:
Mouse   120 TSYAPYGTSSSPVNNEPDKEDLEPEIRIVNGKPK---------KVRKPRTIYSSFQLAALQRRFQ 175

  Fly   337 RQQYMVGPERLYLAHTLKLTEAQVKVWFQNRRIKWRKHHLELTQQRLALIRQTQLPGTSLLGNQV 401
            :.||:..|||..||.:|.||:.|||:||||||.|::|           :.:..::|
Mouse   176 KTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKK-----------MWKSGEIP--------- 220

  Fly   402 SVSANAAHSVSTERTNGCSAASPSLQEEDNEDSKHSLSLSGALPPLSRAQS 452
                       ||:..|.||:.|.                 |.||:|...|
Mouse   221 -----------TEQHPGASASPPC-----------------ASPPVSAPAS 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18599	NP_650701.1	Homeobox	320..372	CDD:278475	27/51 (53%)
Dlx2	NP_034184.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..83		26/133 (20%)
		DLL_N	54..135	CDD:289198	24/165 (15%)
		Homeobox	158..211	CDD:278475	27/52 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..272		12/62 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..332
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810