DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG18599 and Cdx2

DIOPT Version :9

Sequence 1:NP_650701.1 Gene:CG18599 / 42191 FlyBaseID:FBgn0038592 Length:475 Species:Drosophila melanogaster
Sequence 2:NP_031699.2 Gene:Cdx2 / 12591 MGIID:88361 Length:311 Species:Mus musculus


Alignment Length:292 Identity:79/292 - (27%)
Similarity:115/292 - (39%) Gaps:73/292 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 SSHNSNSNHREQLAAAAATATSHAQ--------LIEAAAAHSSLD----VGKSFTIAAILGLQSQ 182
            |.:.|:..|...|..|.....|..|        :..||||.::||    .|.|:..|....|   
Mouse    12 SMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAATANLDSAQSPGPSWPTAYGAPL--- 73

  Fly   183 RKDYNN-------AINLSLHDNNNIIGDDNNKCYTSNPNNNNNNNNNGGS-NSGNNNSSPSVNNF 239
            |:|:|.       |.|...|                        ..|||| .:....|||:..:.
Mouse    74 REDWNGYAPGGAAAANAVAH------------------------GLNGGSPAAAMGYSSPAEYHA 114

  Fly   240 NCDSVAGNGRYLHGGHQHPHPHQAGFAAVAAAV-------GAAPSALQSLQQLHQQHHAQQQATL 297
            :           |..|.||| |.|...:.|:.:       ...|:|..:.:||...  .|::...
Mouse   115 H-----------HHPHHHPH-HPAASPSCASGLLQTLNLGPPGPAATAAAEQLSPS--GQRRNLC 165

  Fly   298 SFQREKLKSD--SHKKSALKNKRVRTIFTPEQLECLEAEFERQQYMVGPERLYLAHTLKLTEAQV 360
            .:.|:..:..  |..|:..|:| .|.::|..|...||.||...:|:....:..||.||.|:|.||
Mouse   166 EWMRKPAQQSLGSQVKTRTKDK-YRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQV 229

  Fly   361 KVWFQNRRIKWRKHHLELTQQRLALIRQTQLP 392
            |:||||||.|.||  ::..||:....:|.|.|
Mouse   230 KIWFQNRRAKERK--IKKKQQQQQQQQQQQPP 259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18599NP_650701.1 Homeobox 320..372 CDD:278475 24/51 (47%)
Cdx2NP_031699.2 Caudal_act 13..170 CDD:282574 42/197 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 111..151 10/51 (20%)
Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q99626 185..215 10/30 (33%)
Homeobox 189..241 CDD:278475 24/51 (47%)
Interaction with 5-mCpG DNA. /evidence=ECO:0000250|UniProtKB:Q99626 227..241 10/13 (77%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..311 8/23 (35%)
4S motif, modulates transactivation activity and protein stability. /evidence=ECO:0000269|PubMed:16027724 281..293
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0850
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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