DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12320 and AAR2

DIOPT Version :9

Sequence 1:	NP_001303479.1	Gene:	CG12320 / 42189	FlyBaseID:	FBgn0038590	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_001258803.1	Gene:	AAR2 / 25980	HGNCID:	15886	Length:	384	Species:	Homo sapiens

Alignment Length:	406	Identity:	135/406 - (33%)
Similarity:	213/406 - (52%)	Gaps:	61/406 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SSMKMDPQLALRLLADGGVLVIAGVPEGTEFGIDLCAYTIGPDFRGVKMIPPGVHYVWCSS--RG 68
            ::::|||:||.||..:|..:||..:|:|||||||..::.:||.||||||||||:|::..||  :.
Human     2 AAVQMDPELAKRLFFEGATVVILNMPKGTEFGIDYNSWEVGPKFRGVKMIPPGIHFLHYSSVDKA 66

  Fly    69 PYGDAAPRVGFVHFFHPNEIVVREWDHELEE--LRPRRIAEPEVERDRIRKNLAQLERVLAPYDY 131
            ...:..||:||....|...:.|..|....||  |.|    .||.|.:.:|.||.:|::.|.||.|
Human    67 NPKEVGPRMGFFLSLHQRGLTVLRWSTLREEVDLSP----APESEVEAMRANLQELDQFLGPYPY 127

  Fly   132 RYVVQWKELTGSVTESCVDRCRPTEGTIRTNIELQSCPDA----------DR-----PRGGAATV 181
            ..:.:|..||..::|:.|::.:|      .|.::.:..|.          ||     ||.|....
Human   128 ATLKKWISLTNFISEATVEKLQP------ENRQICAFSDVLPVLSMKHTKDRVGQNLPRCGIECK 186

  Fly   182 SISRRNAAARILLDESELLPDLKPVEGTAPRFTTVPLRV-PQDALPADVSRHALDCIDAVDKLL- 244
            |.  :...||        ||::||..||..||:.:|.:: |:.|.||::::|::|...|::.:|
Human   187 SY--QEGLAR--------LPEMKPRAGTEIRFSELPTQMFPEGATPAEITKHSMDLSYALETVLN 241

  Fly   245 EGFETA-DGLIEELQLAYAFFLVGYSVESLAHWRKLLGLLAHSQTAVTKHKLTYMKYSEVLAHQL 308
            :.|.:: ..::.|||.|:..||:|...|:..||::||.||..|:.|:.||...|:....:|.|||
Human   242 KQFPSSPQDVLGELQFAFVCFLLGNVYEAFEHWKRLLNLLCRSEAAMMKHHTLYINLISILYHQL 306

  Fly   309 PHLPEELMVPGPHNTVYKD--VRELLVNLHAGGLSVS--------AERLTKRLEKKLGWEFEGLL 363
            ..:|.:..|    :.|.:|  :...|....:...|::        ||:....|.||..|:|..
Human   307 GEIPADFFV----DIVSQDNFLTSTLQVFFSSACSIAVDATLRKKAEKFQAHLTKKFRWDFAA-- 365

  Fly   364 DEDPED-QPVVIELPE 378
              :||| .|||:||||
Human   366 --EPEDCAPVVVELPE 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12320	NP_001303479.1	AAR2	21..360	CDD:283049	117/370 (32%)
		Aar2_N	23..152	CDD:260099	52/132 (39%)
		Aar2_C	211..359	CDD:260100	47/160 (29%)
AAR2	NP_001258803.1	AAR2	17..363	CDD:310121	117/369 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147563
Domainoid	1	1.000	170	1.000	Domainoid score	I3795
eggNOG	1	0.900	-	-		E1_KOG3937
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9170
Inparanoid	1	1.050	195	1.000	Inparanoid score	I3828
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55834
OrthoDB	1	1.010	-	-		D1156337at2759
OrthoFinder	1	1.000	-	-		FOG0005859
OrthoInspector	1	1.000	-	-		oto90817
orthoMCL	1	0.900	-	-		OOG6_103436
Panther	1	1.100	-	-	LDO	PTHR12689
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6
SonicParanoid	1	1.000	-	-		X5626
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800