DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7156 and RPS6KA2

DIOPT Version :9

Sequence 1:	NP_650697.1	Gene:	CG7156 / 42187	FlyBaseID:	FBgn0038588	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_006715612.1	Gene:	RPS6KA2 / 6196	HGNCID:	10431	Length:	761	Species:	Homo sapiens

Alignment Length:	341	Identity:	78/341 - (22%)
Similarity:	136/341 - (39%)	Gaps:	121/341 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 LQILQDRVMQVQCVTKSQQPAAIMKGVEKPASHSLTQSIFLPQQVPYMVQLLAYFQSEQKIFLLL 414
            :::|:...::|:...:|:....|:..|    :|            |::|:|...||:|.|::|:|
Human   118 MKVLKKATLKVRDRVRSKMERDILAEV----NH------------PFIVKLHYAFQTEGKLYLIL 166

  Fly   415 RQAEGGMLYDYLQSYTPTSSKSVNYGELFPSDQEPEEKEAEEPPLTSDSDVSDLVRSSQQLLKSV 479
                     |:|:.           |:||                         .|.|::::
Human   167 ---------DFLRG-----------GDLF-------------------------TRLSKEVM--- 183

  Fly   480 TNTLSNLQAGVVTPKRNKKVDQNRIRSKPIPEQCLRQWACELAIAIHSLHGKGVILRDLHMGNIL 544
                                         ..|:.::.:..|||:|:..||..|:|.|||...|||
Human   184 -----------------------------FTEEDVKFYLAELALALDHLHSLGIIYRDLKPENIL 219

  Fly   545 LGAKGQLLLTYF-YQNEGLTSDDNYVHKALNLEAVANHFVAPE----RPLTFRSDWWSYGVVLYQ 604
            |..:|.:.:|.| ...|.:..|.........:|     ::|||    |..|..:||||:||::::
Human   220 LDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIE-----YMAPEVVNRRGHTQSADWWSFGVLMFE 279

  Fly   605 LLLG-VPY-----KVTHPGQLDL-YGCVQYPSESLEISDHAKDLLEQLLQLSPELRL-----DYD 657
            :|.| :|:     |.|....|.. .|..|:      :|..|:.||..|.:.:|..||     ..:
Human   280 MLTGSLPFQGKDRKETMALILKAKLGMPQF------LSGEAQSLLRALFKRNPCNRLGAGIDGVE 338

  Fly   658 QLQAHPFFKGIDWQAV 673
            :::.||||..|||..:
Human   339 EIKRHPFFVTIDWNTL 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7156	NP_650697.1	PX_SNX15_like	8..124	CDD:132791
		MIT_SNX15	241..315	CDD:239140
		PKc_like	343..665	CDD:304357	73/331 (22%)
RPS6KA2	XP_006715612.1	S_TKc	87..346	CDD:214567	73/331 (22%)
		STKc_RSK_N	91..407	CDD:270734	78/341 (23%)
		STKc_RSK3_C	439..731	CDD:271080
		Pkinase	443..700	CDD:278497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900