Protein Alignment CG7156 and PXK

DIOPT Version :10

• Sequence 1: NP_650697.1
• Gene: CG7156 / 42187
• FlyBaseID: FBgn0038588
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_001336421.1
• Gene: PXK / 54899
• HGNCID: 23326
• Length: 581
• Species: Homo sapiens
• Alignment Length: 464
• Identity: 92/464 - (19%)
• Similarity: 163/464 - (35%)
• Gaps: 140/464 - (30%)

  Fly   233 ASIESDDSDYIYEAALEFSHAVQAEVNLEYA-EAHERYKH-----------GVDLLLNGAKQDSS 285
            |:||:..|   .::..|:...||..:::|.: :...||..           |:.|.|...|...:
Human    22 AAIEASQS---LQSHTEYIIRVQRGISVENSWQIVRRYSDFDLLNNSLQIAGLSLPLPPKKLIGN 83

  Fly   286 EERRFIAKAK--IAKYLARAEEIHANFLANDCPTKKLQFQLSLDTTDGGSVSHLECPWNQLA--- 345
            .:|.|||:.:  :..||   ..|..|.:.::|...| :|   || .:..|.::.|....|::
Human    84 MDREFIAERQKGLQNYL---NVITTNHILSNCELVK-KF---LD-PNNYSANYTEIALQQVSMFF 140

  Fly   346 ----RYKVLQILQD---RVMQVQCVTK-SQQPAAIM------KGVEKPASHSLTQSI--FLPQQV 394
                :::|::.|:|   |:.:...:.| ..||...:      .|.:|..|....|.:  .||..:
Human   141 RSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCL 205

  Fly   395 -PYMVQLLAYFQSEQKIFLLLRQAEGGMLYDYLQSYTPTSSKSVNYGELFPSDQEPEEKEAEEPP 458
             ||:.::.....:|....|:....|.|.|.|.:....|                       ::|
Human   206 HPYIYRVTFATANESSALLIRMFNEKGTLKDLIYKAKP-----------------------KDP- 246

  Fly   459 LTSDSDVSDLVRSSQQLLKSVTNTLSNLQAGVVTPKRNKKVDQNRIRSKPIPEQCLRQWACELAI 523
                            .||...|           ||:.:.::..:|::          :..::..
Human   247 ----------------FLKKYCN-----------PKKIQGLELQQIKT----------YGRQILE 274

  Fly   524 AIHSLHGKGVILRDLHMGNI--------LLGAKGQLL-LTYFYQNEGLTSDDNYVHKALNLEAVA 579
            .:..||.||.....||..|:        ||..:..|| |..||:     |..:...|...||:|.
Human   275 VLKFLHDKGFPYGHLHASNVMLDGDTCRLLDLENSLLGLPSFYR-----SYFSQFRKINTLESVD 334

  Fly   580 NHFVAPERPLTFRSDWWSYGVVLYQLLLG-----VPYKVTHPGQLDLYGCVQYPSESLEISDHAK 639
            .|               .:|.:||::..|     ||.....|........|...:.|.|...:..
Human   335 VH---------------CFGHLLYEMTYGRPPDSVPVDSFPPAPSMAVVAVLESTLSCEACKNGM 384

  Fly   640 DLLEQLLQL 648
            ..:.:|||:
Human   385 PTISRLLQM 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7156	NP_650697.1	PX_SNX15_like	8..124	CDD:132791
		MIT_SNX15	241..315	CDD:239140	18/87 (21%)
		Protein Kinases, catalytic domain	343..665	CDD:473864	63/340 (19%)
PXK	NP_001336421.1	PX_MONaKA	13..132	CDD:132781	29/120 (24%)
		Protein Kinases, catalytic domain	198..345	CDD:473864	41/227 (18%)