DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7156 and Rps6ka6

DIOPT Version :9

Sequence 1:	NP_650697.1	Gene:	CG7156 / 42187	FlyBaseID:	FBgn0038588	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001178650.1	Gene:	Rps6ka6 / 317203	RGDID:	1560817	Length:	860	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	111/539 - (20%)
Similarity:	205/539 - (38%)	Gaps:	166/539 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 KEQTNNESQAKETEIELETKQEPKTDVALTKRDYLRLLTPMASIESDDSDYIYEAALE------- 249
            :.|:.:..:|....:.| .:..|....|:|:|:       ..|.|.|     :|.|.:
  Rat    32 RRQSRSRQRAGTPVVPL-LRYPPLARSAVTQRE-------SWSYEED-----HEPAQQAGCMLVL 83

  Fly   250 ----FSHAVQAEVNLEYAEAHERYKHGVDLLLNGAKQDSSEERRFIAKAKIAKYLARAEEIHANF 310
                |..:|.....|.:|...:.:...:::.  |:...||.|.:.:...|.|..:.|..| |..
  Rat    84 GTSSFFSSVPEAAMLPFAPVEDPWDEEMEVF--GSGSTSSSEPQIVFTMKTAAMVIRQHE-HKE- 144

  Fly   311 LAND---------------CPTKKLQFQLSLDTTDGGSVSHLECPWNQL--ARYKVLQIL-QDRV 357
             .||               |..:.|..::.:       ..|::..:.:.  |::.:|::| |...
  Rat   145 -VNDLKMVDEPMDEGEPVFCRREDLVKEIPI-------TQHVKEGYEKADPAQFDLLKVLGQGSF 201

  Fly   358 MQVQCVTKSQQPAA----IMKGVEKPA-------SHSLTQSIFLPQQVPYMVQLLAYFQSEQKIF 411
            .:|..|.|...|.|    .||.:.|.:       ...:.:.|.:....|::|:|...||:|.|::
  Rat   202 GKVFLVRKKTGPDAGQLYAMKVLRKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLY 266

  Fly   412 LLLRQAEGGMLYDYLQSYTPTSSKSVNYGELFPSDQEPEEKEAEEPPLTSDSDVSDLVRSSQQLL 476
            |:|         |:|:.           |::|                         .|.|:::|
  Rat   267 LIL---------DFLRG-----------GDVF-------------------------TRLSKEVL 286

  Fly   477 KSVTNTLSNLQAGVVTPKRNKKVDQNRIRSKPIPEQCLRQWACELAIAIHSLHGKGVILRDLHMG 541
                                            ..|:.::.:..|||:|:..||..|::.|||...
  Rat   287 --------------------------------FTEEDVKFYLAELALALDHLHRLGIVYRDLKPE 319

  Fly   542 NILLGAKGQLLLTYFYQNEGLTSDDNYVHKALNLEAVANHFVAPE----RPLTFRSDWWSYGVVL 602
            ||||...|.:.||.|    ||:.:.....|..........::|||    |..:..:|||||||::
  Rat   320 NILLDEIGHIKLTDF----GLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLM 380

  Fly   603 YQLLLG-VPYKVTHPGQ-LDL-----YGCVQYPSESLEISDHAKDLLEQLLQLSPELRL---DYD 657
            :::|.| :|::.....: :::     .|..|:      :|..|:.||..|.:.:|..||   ..:
  Rat   381 FEMLTGTLPFQGKDRNETMNMILKAKLGMPQF------LSAEAQSLLRMLFKRNPANRLGSEGVE 439

  Fly   658 QLQAHPFFKGIDWQAVLEQ 676
            :::.|.||..|||..:.::
  Rat   440 EVKRHAFFSSIDWNKLYKR 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7156	NP_650697.1	PX_SNX15_like	8..124	CDD:132791
		MIT_SNX15	241..315	CDD:239140	17/99 (17%)
		PKc_like	343..665	CDD:304357	76/349 (22%)
Rps6ka6	NP_001178650.1	S_TKc	190..447	CDD:214567	75/343 (22%)
		STKc_RSK_N	194..508	CDD:270734	79/352 (22%)
		STKc_RSK_C	543..829	CDD:270993
		Pkinase	543..800	CDD:278497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900