DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7156 and Snx14

DIOPT Version :9

Sequence 1:	NP_650697.1	Gene:	CG7156 / 42187	FlyBaseID:	FBgn0038588	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_038937462.1	Gene:	Snx14 / 315871	RGDID:	1310921	Length:	984	Species:	Rattus norvegicus

Alignment Length:	727	Identity:	125/727 - (17%)
Similarity:	207/727 - (28%)	Gaps:	294/727 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 CLVVWKRFHD-----------VKRLHRELSRRHKSLQLPGKLPVPTDSTYFKRFDAAVIQRRKE- 96
            ||.| :.|:|           :..||.||.:.:|:..|...:    |...|..|....|||..|
  Rat   393 CLTV-EEFNDRILRPELSNDEMLSLHEELQKIYKTYCLDESI----DKIRFDPFIVEEIQRIAEG 452

  Fly    97 -YI-------LQLLDFAAQHPALYKCSTFTQFF-------------QETPSPNGSPLKKLYVERS 140
             ||       ::.|..|.:|......:.||..|             .|:|:.|..     :...|
  Rat   453 PYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSK-----FNRGS 512

  Fly   141 LRL----QTEDNGCGSGGSETGTCAGAIADICDKLDLPYDPHDAGGITPLDPRCDKEQTNNESQA 201
            |.|    .|:..|...|.|..|:....:                                    .
  Rat   513 LSLDDFRSTQKRGESFGISRIGSKIKGV------------------------------------F 541

  Fly   202 KETEIELETKQEPKTDVALTKRDYLRLLTPMASIESDDSDYIYE--AALEFSHAVQA-------- 256
            |.|.:|                   ..:.|...:...:.|:|.|  ..||....|:|
  Rat   542 KSTTME-------------------GAVLPSYGVAEGEDDFIEEGIVVLEDDSPVEAVSTPNTPR 587

  Fly   257 -----EVNLEYAEAHERYKHGVDLLLNGAKQDSSEERRFIAKAKIAKYLARAEEIHANFLANDCP 316
                 ::::.|.:..|               |.|.||:           .:.|.|..
  Rat   588 NLAAWKISIPYVDFFE---------------DPSSERK-----------EKKERIPV-------- 618

  Fly   317 TKKLQFQLSLDTTDGGSVSHLECPWNQLARYKVLQILQDRVMQVQ-CVTKSQQPAAIMKGVEKPA 380
                 |.:.::..|..:|.|....|:...||....:|:.::.:.. ....:|.|:   |.:..|.
  Rat   619 -----FCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGTFPDAQLPS---KRIIGPK 675

  Fly   381 SHSLTQS------IFLPQQVPY----MVQLLAYFQSEQKIFLLLRQAEGGMLYDYLQSYTPTSSK 435
            ::...:|      .:|.:.|.:    ..||||.|.|          ..||.. .:|....|
  Rat   676 NYEFLKSKREEFQEYLQKLVQHPELSNSQLLADFLS----------PNGGET-QFLDKILP---- 725

  Fly   436 SVNYGELF---PSDQEPEEKEAEEPPLTSDSDVSDLVRSSQQLLKSVTNTLSNLQAGVVTPKRNK 497
            .||.|::.   |.....|:.:..||                 .:.|..|:..:
  Rat   726 DVNLGKIIKSVPGKLMKEKGQHLEP-----------------FIMSFINSCES------------ 761

  Fly   498 KVDQNRIRSKPIPEQCLRQWACELAIAIHSLHGKGVILRDLHMGNILLGAKGQLLLTYFYQNEGL 562
                    .||.|.:      .||.|...:......:..||...|....           :|...
  Rat   762 --------PKPKPSR------PELTILSPTSENNKKLFNDLFKNNANRA-----------ENTER 801

  Fly   563 TSDDNYVHKALNLEAVANHFVAPERPLTFRSDWWSYGVVLYQLLLGVPYKVTHPGQLDLYG---- 623
            ..:.||..:.:.::.|.::.:...|.:....||      |:.||:|.  ::.....|::|.
  Rat   802 KQNQNYFMEVMTVDGVYDYLMYVGRVVFQVPDW------LHHLLMGT--RILFKNTLEMYTDYYL 858

  Fly   624 -------------------------CVQYPSESLEISDH-AKDLLEQLLQLSPEL---------- 652
                                     |......||:.... ||...|:::...|:|
  Rat   859 QCKLEQLFQEHRLVSLITLLRDAIFCENTEPRSLQDKQKGAKQTFEEMMNYIPDLIVKCIGEETK 923

  Fly   653 ----RLDYDQLQ 660
                ||.:|.||
  Rat   924 YESIRLLFDGLQ 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7156	NP_650697.1	PX_SNX15_like	8..124	CDD:132791	26/112 (23%)
		MIT_SNX15	241..315	CDD:239140	15/88 (17%)
		PKc_like	343..665	CDD:304357	64/376 (17%)
Snx14	XP_038937462.1	PXA	157..326	CDD:396666
		RGS_SNX14	367..493	CDD:188677	26/104 (25%)
		PX_SNX14	591..713	CDD:132787	29/173 (17%)
		Nexin_C	834..938	CDD:400794	20/110 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900