DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7156 and SNX15

DIOPT Version :9

Sequence 1:	NP_650697.1	Gene:	CG7156 / 42187	FlyBaseID:	FBgn0038588	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_037438.2	Gene:	SNX15 / 29907	HGNCID:	14978	Length:	342	Species:	Homo sapiens

Alignment Length:	355	Identity:	92/355 - (25%)
Similarity:	150/355 - (42%)	Gaps:	87/355 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WIHSFTVTDTQEHKGGYTIYKITSIVFPRSVPQALTCLVVWKRFHDVKRLHRELSRRHKSL-QLP 71
            ::..:||:|.:.|..|||.||:|:....:..|:.:..:|||||:.|.::||.:|:..|::| :..
Human     9 FLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRL 73

  Fly    72 GKLPVPTDSTYFKRFDAAVIQRRKEYILQLLDFAAQHPALYKCSTFTQFFQ-------------- 122
            .:.|....:..|.||:|:||:.|::....||.|....|||.......:||:
Human    74 EEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPLEVSRDL 138

  Fly   123 --------ETPSPNGSPLKKLYVERSLRLQTEDNGCGSGGSETGTCAGAIADICDKLDLPYDPHD 179
                    .||.|:...|.:|       |..|..|                  .::|::|.||
Human   139 HILPPPLIPTPPPDDPRLSQL-------LPAERRG------------------LEELEVPVDP-- 176

  Fly   180 AGGITPLDP---------RCD--KEQTNNESQAKETEIELE-----TKQE---PK----TDVALT 221
                .|..|         .|:  :|.:.:.::...||.||.     :|:|   |.    .::|..
Human   177 ----PPSSPAQEALDLLFNCESTEEASGSPARGPLTEAELALFDPFSKEEGAAPSPTHVAELATM 237

  Fly   222 KRDYLRL----LTPMASIESDDSD------YIYEAALEFSHAVQAEVNLEYAEAHERYKHGVDLL 276
            :.:..||    ..|....|.:|.:      |:.:|....:.|::.|....||.|.:.|:.||.:|
Human   238 EVESARLDQEPWEPGGQEEEEDGEGGPTPAYLSQATELITQALRDEKAGAYAAALQGYRDGVHVL 302

  Fly   277 LNGAKQDSSEERRFIAKAKIAKYLARAEEI 306
            |.|...|....|:...|.|.|:||.|||||
Human   303 LQGVPSDPLPARQEGVKKKAAEYLKRAEEI 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7156	NP_650697.1	PX_SNX15_like	8..124	CDD:132791	38/138 (28%)
		MIT_SNX15	241..315	CDD:239140	25/72 (35%)
		PKc_like	343..665	CDD:304357
SNX15	NP_037438.2	PX_domain	9..126	CDD:321991	38/116 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..267		3/21 (14%)
		MIT_SNX15	267..341	CDD:239140	25/66 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I8103
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D135297at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15508
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.880