DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7156 and Rps6kc1

DIOPT Version :9

Sequence 1:	NP_650697.1	Gene:	CG7156 / 42187	FlyBaseID:	FBgn0038588	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_006250521.1	Gene:	Rps6kc1 / 289342	RGDID:	1306578	Length:	1045	Species:	Rattus norvegicus

Alignment Length:	1096	Identity:	230/1096 - (20%)
Similarity:	367/1096 - (33%)	Gaps:	493/1096 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WIHS------FTVTDTQEHKGGYTIYKITSIVFPRSVPQALTCLVVWKRFHDVKRLHRELSRRHK 66
            |.||      :|||:.|.|..||||||:|:.|..|..|:.:..::||:|:.|.|:|||||.:.|:
  Rat     5 WGHSADLARFYTVTEPQRHPRGYTIYKVTARVVSRRNPEDVQEIIVWRRYSDFKKLHRELWQIHR 69

  Fly    67 SLQLPGKL-PVPTDSTYFKRFDAAVIQRRKEYILQLLDFAAQHPALYKCSTFTQFFQETPSPNGS 130
            :.....:| |.....|.|.|||..||:.|::....||.|:|..||||.......||:.....:||
  Rat    70 NAFRHSELFPPFAKGTVFGRFDKTVIEERRQCAEDLLQFSANIPALYNSKQLQDFFKGGIISDGS 134

  Fly   131 PL---KKLYVERSLRLQTEDNGCGSGGSETGT-------CAGAIADICD-------------KLD 172
            .|   .:.|.:......:|   ||:.|..:.:       .|.::|::.|             .|.
  Rat   135 ELIGPAEAYPDSLANTFSE---CGTEGFSSDSDLLSLTVDADSLAEVDDGMASRQGSPSRAFGLS 196

  Fly   173 LPYDPHDAGGI-TPLDPRCDKEQTNNESQAKETEIELETKQEPKTDVALTKRDYLRL---LTPMA 233
            :..|....|.: :.::|        ::::.:|:.....:..:|:    |.:||||..   |..:|
  Rat   197 VSADSSAVGAVASDIEP--------SKAEDRESRSLFPSSLKPR----LGRRDYLEKAGELIKLA 249

  Fly   234 SIESDDSDYIYEAALEFSHAVQAEVNLEYAEAHERYKHGVDLLLNGAKQDSSEERRFIAKAKIAK 298
            ..:.::.|  ||||.:|                  |:.||||||.|.:.:||..||...|.:.|:
  Rat   250 LKKEEEDD--YEAASDF------------------YRKGVDLLLEGVQGESSPTRREAVKRRTAE 294

  Fly   299 YLARAEEIHANFLANDCPTKKLQFQLSLDT--TDGGSVSHLECPWN------QLARYKVLQILQD 355
            ||.|||.|        |   .|:....|||  ...|::|. ..|||      :|..::||.:: |
  Rat   295 YLMRAESI--------C---SLRVTAQLDTGPQPPGALSS-RPPWNLRSPAEELKAFRVLGVI-D 346

  Fly   356 RVMQVQCVTKSQQPAAIMKGVEKPASHSLTQSIFLPQQVPYMVQLLAYFQSEQKIFLLLRQAEGG 420
            :|:.|. .|:::| ..|:||:.|.:..|..:...:|:.||.||.|..|..||:.:||:|:.||||
  Rat   347 KVLLVM-DTRTEQ-TFILKGLRKSSECSRNRKTIIPRCVPNMVCLHTYIISEESVFLVLQHAEGG 409

  Fly   421 MLYDYLQ---------------------------------------------------------S 428
            .|:.|:.                                                         |
  Rat   410 KLWSYISKFLNRSSRESLDIKEARPPMPPRVRLQQPSASPQGSYSVESRGSDTGSMLKVLPLKTS 474

  Fly   429 YTPTSSKSVN---------------------------------YGE------------------- 441
            .||:|....|                                 ||:
  Rat   475 LTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEECTAGYLTLCNEYGQEKLDLTSLNEESVMQPEGE 539

  Fly   442 --------------------------LFPSDQ--------------------------------- 447
                                      .||.|:
  Rat   540 NADSQAVRSFPASLTADSASPSTQLKFFPGDEGLEAVCSPRTSDSLRRSKNSPMEFFRIDSKDST 604

  Fly   448 ---------------EPE-------------------------EKEAEE----------PPLTSD 462
                           :||                         |.||::          |.::..
  Rat   605 SELLGLDSGEKLHSLKPEPLKALFTLEDGDSPSQSFDAGKSQGESEAQDSISRGSDDSVPVISFK 669

  Fly   463 SDVSDLVRSSQQ----LLKSVTNTL---------------------------------------- 483
            ...|:.|.|:::    ||.::...|
  Rat   670 EAASEDVCSAEEGRPDLLVNLPGELQPTKETSAVDPTKFSQASIGRLEAPDVLCLRLSSEQCHDL 734

  Fly   484 -----------SNLQAGVVTPKRNKKVD------------------------------------- 500
                       :..:.|.|||:|:.:.|
  Rat   735 GQEGPEELSHPTEFRPGGVTPERSAQADLGVLFTATVDHSSSQDQFLFSSLHSESDRLGQVEGAV 799

  Fly   501 ----------------------------------------------QNRIRSKP----------- 508
                                                          :.::||..
  Rat   800 TSQDLQESLFHIASPCSGAKEDSAHTDTATSEEVLLFTEPSKEGDSEAKVRSVGAGGAEKEVHQI 864

  Fly   509 ---------------IPEQCLRQWACELAIAIHSLHGKGVILRDLHMGNILLGAKGQLLLTYFYQ 558
                           |||.|:::||.|:.:|:.:||.:|::.|||:..||||...|.:.||||
  Rat   865 FEDLDQRLAVSARLFIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDGGHIQLTYF-- 927

  Fly   559 NEGLTSDDNYVHKALNLEAVANHFVAPE----RPLTFRSDWWSYGVVLYQLLLGVPYKVTHPGQL 619
                 |..:.|....:.:|:|..:.|||    ...|...||||.|.||::||.|......||..:
  Rat   928 -----SRWSEVEDLCDSDAIARMYCAPEVGAVTEETEACDWWSLGAVLFELLTGKTLVECHPAGI 987

  Fly   620 DLYGCVQYPSESLEISDHAKDLLEQLLQLSPELRL-----DYDQLQAHPFFKGIDW 670
            :.:..:..|.   .:|:.|:.|::||||.:|..||     ..:.:::||||..:||
  Rat   988 NTHTTLNMPD---CVSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFFTPVDW 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7156	NP_650697.1	PX_SNX15_like	8..124	CDD:132791	49/122 (40%)
		MIT_SNX15	241..315	CDD:239140	26/73 (36%)
		PKc_like	343..665	CDD:304357	117/712 (16%)
Rps6kc1	XP_006250521.1	PX_RPK118_like	11..128	CDD:132820	46/116 (40%)
		MIT_SNX15	237..305	CDD:239140	32/98 (33%)
		PKc_like	334..>420	CDD:304357	31/88 (35%)
		STKc_RPK118_like	<858..1035	CDD:270728	56/186 (30%)
		S_TKc	<867..1035	CDD:214567	56/177 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6776
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8244
Inparanoid	1	1.050	271	1.000	Inparanoid score	I2925
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D135297at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46207
orthoMCL	1	0.900	-	-		OOG6_107055
Panther	1	1.100	-	-	LDO	PTHR15508
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5585
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870