DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7156 and rps6kc1

DIOPT Version :9

Sequence 1:	NP_650697.1	Gene:	CG7156 / 42187	FlyBaseID:	FBgn0038588	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_002934734.3	Gene:	rps6kc1 / 100492605	XenbaseID:	XB-GENE-985541	Length:	1066	Species:	Xenopus tropicalis

Alignment Length:	1094	Identity:	235/1094 - (21%)
Similarity:	357/1094 - (32%)	Gaps:	482/1094 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FTVTDTQEHKGGYTIYKITSIVFPRSVPQALTCLVVWKRFHDVKRLHRELSRRHKSL-QLPGKLP 75
            :||||.:.|:.|:||||:|:.:..|..|:.:..:|.|||:.|.|:|||:|.:.||:| |.....|
Frog    15 YTVTDPRRHQKGFTIYKVTARIVSRKNPEDVQEIVAWKRYSDFKKLHRDLWQIHKNLFQQQELFP 79

  Fly    76 VPTDSTYFKRFDAAVIQRRKEYILQLLDFAAQHPALYKCSTFTQFFQETPSPNGS-------PLK 133
            ....:..|.|||.:||:.|::....||.|:|..||||..|....||:.....:||       ||.
Frog    80 PFAKAKLFGRFDESVIEERRQCAEDLLQFSANIPALYNSSQLEDFFKGGEVHDGSDLIGPAEPLT 144

  Fly   134 KLYVERSLRLQTEDNGCGSGGSETGTCA------------GAIADICDKLDLPYDPHDAGGITPL 186
            .|         |:.....|......:||            |.::...|.:.|..|.....||.
Frog   145 DL---------TDSISDCSSDVRKDSCALDDLTFTSVSECGGLSSDSDLISLTVDRDSLSGID-- 198

  Fly   187 DPRCDKEQTNNESQAK--------ETEIEL-------ETKQEPKTD--VALTKRDYLRLLTPMAS 234
                |...:|..|.:|        |:.|:.       ..|.|.:.|  .:...|...:|:.|
Frog   199 ----DGMASNQTSPSKFLGVLPSPESSIQSVFASSHEGAKAEGERDRRSSFPARLKQKLIKP--- 256

  Fly   235 IESDDSDYIYEAALEFSHAVQAEVNLEYAEAHERYKHGVDLLLNGAKQDSSEERRFIAKAKIAKY 299
                  ||:.:|....:.|::.|...:|..|.|.||.||||||.|.:.:.|..||...|.|.|:|
Frog   257 ------DYLTKAGSLITMAMKKESEQDYGSAIEFYKKGVDLLLEGVQGEPSPTRREAVKKKTAEY 315

  Fly   300 LARAEEIHANFLANDCPTKKLQFQLSLDTTDGGSVS-----HLECPWNQLARYKVLQILQDRVMQ 359
            |.|||.|.:..|      |:...:||   ...|::|     :|..|..:|..::||.:: |:|:.
Frog   316 LMRAESISSLCL------KRSPEELS---APPGALSSRPSWNLRSPAEELKAFRVLGVI-DKVLL 370

  Fly   360 VQCVTKSQQPAAIMKGVEKPASHSLTQSIFLPQQVPYMVQLLAYFQSEQKIFLLLRQAEGGMLYD 424
            | ..||:|: ..|:||:.| :.|..|:...:|:.||.||.|..|..||:.:||:|:.||||.|::
Frog   371 V-LDTKTQE-TFILKGLRK-SEHCATRKTIIPRCVPNMVCLREYIISEESVFLVLQHAEGGKLWN 432

  Fly   425 YL---------QSYTPTSSKSVNYGE-----LFP------------------------------- 444
            ||         :|:....|||.|..|     |.|
Frog   433 YLSKFFSISAEESFDIPPSKSSNSDEDLLKHLAPCSKSSLDSRGSSDRNMLSVQPLQSSFTLSSQ 497

  Fly   445 SDQEPEEKEAEEPPL-----TSDSD---------------------------------------- 464
            .|...:::|..|.||     .|.||
Frog   498 DDSSTQDEEGRESPLKWADSASSSDEECTTSYLTLCREYSQEKVEPDTISVEPLLSLDEQGDTPQ 562

  Fly   465 ----------------------------------------VSDLVRSSQ---------------- 473
                                                    ::|.:|.|:
Frog   563 DFIDLEEPHCTTYNALKSQMTCEEPLFNDESGHSAPKPIMMADALRKSRDSPMEFFRIDSRESNS 627

  Fly   474 ----------------------------------------------------------------- 473

Frog   628 DFGDHGSKAGTVEPYPPFQDDLDDNEFEPERPHVGTSVKITHDAISRGSNDSVPVISFKDAALDD 692

  Fly   474 ---------QLLKSVTNT---------LSN--LQAGVVTPK------------------------ 494
                     .||.::..|         ..|  |:..::.||
Frog   693 ICSIDEGRPDLLVNLPGTEQMDETQVVFQNNILETDIIEPKLLETPDVLLVNNSLEQLTGLDANP 757

  Fly   495 ----------------------RNKK----------------------------------VDQNR 503
                                  .||:                                  .|...
Frog   758 LETVEQTWGPHSQIIEQCQVNANNKESSASAPIEPLESRGALSDLDTLLPASLTFPLPYSTDTEG 822

  Fly   504 IRSKP------------------------------------------------------------ 508
            |...|
Frog   823 ISQVPCESSSDVKNVCGPQETLPLANSDELTSTLVQLKIKIEDTDAAIDGKREFREEKEIHKLFQ 887

  Fly   509 -------------IPEQCLRQWACELAIAIHSLHGKGVILRDLHMGNILLGAKGQLLLTYFYQNE 560
                         |||.|:::||.|:.:|:.:|||:|::.|||:..||||..:|.:.||||
Frog   888 ELDAKLSAASNVIIPETCIQRWAAEIVLALDALHGEGIVCRDLNPNNILLNDRGHIQLTYF---- 948

  Fly   561 GLTSDDNYVHKALNLEAVANHFVAPE----RPLTFRSDWWSYGVVLYQLLLGVPYKVTHPGQLDL 621
               |..:.|..:.:.:|:...:.|||    ...|...||||.|.:|::||........||..::.
Frog   949 ---SRWSEVEDSCDSDAIEKMYCAPEVGGISEETQACDWWSLGALLFELLTRKALAECHPAGINT 1010

  Fly   622 YGCVQYPSESLEISDHAKDLLEQLLQLSPELRL-----DYDQLQAHPFFKGIDW 670
            :..|..|.   .:|..|:.|::||||.:|..||     ..:.:::||||.|:||
Frog  1011 HTTVSVPE---YVSKEARALVQQLLQFNPMERLGAGVAGVEDIKSHPFFAGVDW 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7156	NP_650697.1	PX_SNX15_like	8..124	CDD:132791	46/112 (41%)
		MIT_SNX15	241..315	CDD:239140	30/73 (41%)
		PKc_like	343..665	CDD:304357	120/714 (17%)
rps6kc1	XP_002934734.3	PX_RPK118_like	11..128	CDD:132820	46/112 (41%)
		MIT_SNX15	257..331	CDD:239140	31/79 (39%)
		PKc_like	354..>439	CDD:419665	34/88 (39%)
		STKc_RPK118_like	<875..1056	CDD:270728	55/190 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I6905
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8244
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2863
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D135297at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49287
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3828
SonicParanoid	1	1.000	-	-		X5585
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.000