DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 14-3-3epsilon and BMH2

DIOPT Version :9

Sequence 1:	NP_732309.1	Gene:	14-3-3epsilon / 42186	FlyBaseID:	FBgn0020238	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	NP_010384.3	Gene:	BMH2 / 851676	SGDID:	S000002506	Length:	273	Species:	Saccharomyces cerevisiae

Alignment Length:	257	Identity:	182/257 - (70%)
Similarity:	213/257 - (82%)	Gaps:	7/257 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RENNVYKAKLAEQAERYDEMVEAMKKVASMDVELTVEERNLLSVAYKNVIGARRASWRIITSIEQ 68
            ||::||.||||||||||:||||.||.|||...||:||||||||||||||||||||||||::||||
Yeast     5 REDSVYLAKLAEQAERYEEMVENMKAVASSGQELSVEERNLLSVAYKNVIGARRASWRIVSSIEQ 69

  Fly    69 KEENK-GAEEKLEMIKTYRGQVEKELRDICSDILNVLEKHLIPCATSGESKVFYYKMKGDYHRYL 132
            |||:| .:|.::|:|::||.::|.||..|..|||:||:.||||.||:||||||||||||||||||
Yeast    70 KEESKEKSEHQVELIRSYRSKIETELTKISDDILSVLDSHLIPSATTGESKVFYYKMKGDYHRYL 134

  Fly   133 AEFATGSDRKDAAENSLIAYKAASDIAMNDLPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKA 197
            |||::|..|:.|..:||.|||.||:||..:||||||||||||||||||||||.||||:||.|||.
Yeast   135 AEFSSGDAREKATNSSLEAYKTASEIATTELPPTHPIRLGLALNFSVFYYEIQNSPDKACHLAKQ 199

  Fly   198 AFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQAEEVDPNAGDGEPKEQIQDVEDQ 259
            |||||||||||||||||||||||||||||||||||||:.      .:|..:.::|.|..:.|
Yeast   200 AFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDIS------ESGQEDQQQQQQQQQQQ 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
14-3-3epsilon	NP_732309.1	14-3-3_epsilon	4..233	CDD:206757	175/229 (76%)
BMH2	NP_010384.3	BMH1	1..273	CDD:227373	182/257 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346488
Domainoid	1	1.000	338	1.000	Domainoid score	I159
eggNOG	1	0.900	-	-		E1_COG5040
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100743
Inparanoid	1	1.050	353	1.000	Inparanoid score	I388
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53683
OrthoFinder	1	1.000	-	-		FOG0000128
OrthoInspector	1	1.000	-	-		otm46693
orthoMCL	1	0.900	-	-		OOG6_100283
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1059
SonicParanoid	1	1.000	-	-		X206
TreeFam	1	0.960	-	-
	14	13.690