DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 14-3-3epsilon and ywhae2

DIOPT Version :9

Sequence 1:	NP_732309.1	Gene:	14-3-3epsilon / 42186	FlyBaseID:	FBgn0020238	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	NP_001013359.1	Gene:	ywhae2 / 503763	ZFINID:	ZDB-GENE-050306-44	Length:	255	Species:	Danio rerio

Alignment Length:	261	Identity:	205/261 - (78%)
Similarity:	231/261 - (88%)	Gaps:	10/261 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTERENNVYKAKLAEQAERYDEMVEAMKKVASMDVELTVEERNLLSVAYKNVIGARRASWRIITS 65
            |.:||:.||:|||||||||||||||:||.||..|.:|:|||||||||||||||||||||||||:|
Zfish     1 MADREHLVYQAKLAEQAERYDEMVESMKNVAGKDEDLSVEERNLLSVAYKNVIGARRASWRIISS 65

  Fly    66 IEQKEENKGAEEKLEMIKTYRGQVEKELRDICSDILNVLEKHLIPCATSGESKVFYYKMKGDYHR 130
            ||||||:||..:||:||:.||..||.||:.||:|||:||:|||||.|.:||||||||||||||||
Zfish    66 IEQKEESKGGADKLKMIREYRQTVENELKSICNDILDVLDKHLIPAANTGESKVFYYKMKGDYHR 130

  Fly   131 YLAEFATGSDRKDAAENSLIAYKAASDIAMNDLPPTHPIRLGLALNFSVFYYEILNSPDRACRLA 195
            ||||||||:|||:||||||:||||||||||.:|||||||||||||||||||||||||||||||||
Zfish   131 YLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLA 195

  Fly   196 KAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQAEEVDPNAGDGEPKEQI--QDVED 258
            ||||||||||||||||:||||||||||||||||||||||:|        ||||.:.:.  ||.|:
Zfish   196 KAAFDDAIAELDTLSEDSYKDSTLIMQLLRDNLTLWTSDIQ--------GDGEEQSKTAPQDAEE 252

  Fly   259 Q 259
            :
Zfish   253 E 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
14-3-3epsilon	NP_732309.1	14-3-3_epsilon	4..233	CDD:206757	193/228 (85%)
ywhae2	NP_001013359.1	14-3-3	4..233	CDD:295170	193/228 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	395	1.000	Domainoid score	I732
eggNOG	1	0.900	-	-		E1_COG5040
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100743
Inparanoid	1	1.050	425	1.000	Inparanoid score	I1738
OMA	1	1.010	-	-		QHG53683
OrthoDB	1	1.010	-	-		D1176818at2759
OrthoFinder	1	1.000	-	-		FOG0000128
OrthoInspector	1	1.000	-	-		otm24345
orthoMCL	1	0.900	-	-		OOG6_100283
Panther	1	1.100	-	-	LDO	PTHR18860
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1059
SonicParanoid	1	1.000	-	-		X206
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870