DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 14-3-3epsilon and Ywhae

DIOPT Version :9

Sequence 1:	NP_732309.1	Gene:	14-3-3epsilon / 42186	FlyBaseID:	FBgn0020238	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	NP_033562.3	Gene:	Ywhae / 22627	MGIID:	894689	Length:	255	Species:	Mus musculus

Alignment Length:	262	Identity:	218/262 - (83%)
Similarity:	237/262 - (90%)	Gaps:	10/262 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTERENNVYKAKLAEQAERYDEMVEAMKKVASMDVELTVEERNLLSVAYKNVIGARRASWRIITS 65
            |.:||:.||:|||||||||||||||:|||||.|||||||||||||||||||||||||||||||:|
Mouse     1 MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISS 65

  Fly    66 IEQKEENKGAEEKLEMIKTYRGQVEKELRDICSDILNVLEKHLIPCATSGESKVFYYKMKGDYHR 130
            |||||||||.|:||:||:.||..||.||:.||.|||:||:|||||.|.:||||||||||||||||
Mouse    66 IEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHR 130

  Fly   131 YLAEFATGSDRKDAAENSLIAYKAASDIAMNDLPPTHPIRLGLALNFSVFYYEILNSPDRACRLA 195
            ||||||||:|||:||||||:||||||||||.:|||||||||||||||||||||||||||||||||
Mouse   131 YLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLA 195

  Fly   196 KAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQAEEVDPNAGDGEP--KEQIQDVED 258
            |||||||||||||||||||||||||||||||||||||||||        ||||.  ||.:|||||
Mouse   196 KAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQ--------GDGEEQNKEALQDVED 252

  Fly   259 QD 260
            ::
Mouse   253 EN 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
14-3-3epsilon	NP_732309.1	14-3-3_epsilon	4..233	CDD:206757	201/228 (88%)
Ywhae	NP_033562.3	14-3-3_epsilon	4..233	CDD:206757	201/228 (88%)
Ywhae	NP_033562.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..255		14/29 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	394	1.000	Domainoid score	I769
eggNOG	1	0.900	-	-		E1_COG5040
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100743
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1751
Isobase	1	0.950	-	0	Normalized mean entropy	S40
OMA	1	1.010	-	-		QHG53683
OrthoDB	1	1.010	-	-		D1176818at2759
OrthoFinder	1	1.000	-	-		FOG0000128
OrthoInspector	1	1.000	-	-		oto92832
orthoMCL	1	0.900	-	-		OOG6_100283
Panther	1	1.100	-	-	LDO	PTHR18860
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1059
SonicParanoid	1	1.000	-	-		X206
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.820