DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdh2 and MDH2

DIOPT Version :9

Sequence 1:	NP_650696.1	Gene:	Mdh2 / 42185	FlyBaseID:	FBgn0262559	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_014515.2	Gene:	MDH2 / 853994	SGDID:	S000005486	Length:	377	Species:	Saccharomyces cerevisiae

Alignment Length:	362	Identity:	152/362 - (41%)
Similarity:	206/362 - (56%)	Gaps:	51/362 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QQNNYKVTVCGAAGGIGQPLSLLLK---------QNPLVT--DLALYDIVHTP--GVAADLSHID 72
            :|::.|:.:.||||||||.||||||         .|..||  .|||||:....  ||.|||||||
Yeast    10 EQDSLKIAILGAAGGIGQSLSLLLKAQLQYQLKESNRSVTHIHLALYDVNQEAINGVTADLSHID 74

  Fly    73 TKSKTAGFIGADQLGDSLKGSDVVVIPAGVPRKPGMTRDDLFNVNAGIIKDISNSIAKNC--PKA 135
            |....:....|..:.:.|..:.:||||||||||||||||||||||||||..:.:|||:.|  .|.
Yeast    75 TPISVSSHSPAGGIENCLHNASIVVIPAGVPRKPGMTRDDLFNVNAGIISQLGDSIAECCDLSKV 139

  Fly   136 LVAIITNPVNTCVPI-AAEILK------KAGVYDPKRLFGVSTLDVVRARAF---IGHALGVDPQ 190
            .|.:|:||||:.||: .:.|||      .:|:  .:|:.||:.||:|||..|   |....|:.|:
Yeast   140 FVLVISNPVNSLVPVMVSNILKNHPQSRNSGI--ERRIMGVTKLDIVRASTFLREINIESGLTPR 202

  Fly   191 T---VQIPVIGGHSGVTILPVLSQSQPLFKGNQDTIEKLTVRIQEAGTEVVKAKAGAGSATLSMA 252
            .   ..:||||||||.||:|:.|||..|.:.|:|.::.|..|:|..|.||||||.|.||||||||
Yeast   203 VNSMPDVPVIGGHSGETIIPLFSQSNFLSRLNEDQLKYLIHRVQYGGDEVVKAKNGKGSATLSMA 267

  Fly   253 YAGARFAGSLLKGLNGEKNVIECSY------------------VQSTVTEATFFSTPLVLGKNGV 299
            :||.:.....:..|.|....|..:|                  :...|..|.:|:.||.:...||
Yeast   268 HAGYKCVVQFVSLLLGNIEQIHGTYYVPLKDANNFPIAPGADQLLPLVDGADYFAIPLTITTKGV 332

  Fly   300 Q--ENLGLPKLNDYEK-KLLEAAIPELKKNIQKGIDF 333
            .  :...:.::||.|: ::|...:.:|||||.||::|
Yeast   333 SYVDYDIVNRMNDMERNQMLPICVSQLKKNIDKGLEF 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdh2	NP_650696.1	MDH_glyoxysomal_mitochondrial	25..334	CDD:133422	151/358 (42%)
MDH2	NP_014515.2	MDH_euk_gproteo	15..372	CDD:130833	151/357 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344504
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56560
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11540
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.810