DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdh2 and UEVLD

DIOPT Version :9

Sequence 1:	NP_650696.1	Gene:	Mdh2 / 42185	FlyBaseID:	FBgn0262559	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_001035787.1	Gene:	UEVLD / 55293	HGNCID:	30866	Length:	471	Species:	Homo sapiens

Alignment Length:	295	Identity:	60/295 - (20%)
Similarity:	105/295 - (35%)	Gaps:	57/295 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KVTVCGAAGGIGQPLSLLLKQNPLVTDLALYDIVH-TPGVAADLS-------------HIDTKSK 76
            |:||.| .|.:|...:|.:....:...|.|.|:.. |.|...||.             .....||
Human   184 KITVVG-GGELGIACTLAISAKGIADRLVLLDLSEGTKGATMDLEIFNLPNVEISKDLSASAHSK 247

  Fly    77 TAGFIGADQLGDSLKGSDVVVIPAGVPRKPGMTRDDLFNVNAGIIKDISNSIAKNCPKALVAIIT 141
            ...|. .:.||.|....|||                  ..|..:.:.:..::......:::.:.:
Human   248 VVIFT-VNSLGSSQSYLDVV------------------QSNVDMFRALVPALGHYSQHSVLLVAS 293

  Fly   142 NPVNTCVPIAAEILKKAGVYDPKRLFGVS-TLDVVRARAFIGHALGVDPQTVQIPVIGGHSGVTI 205
            .||.    |...:..|...:...|:.|:. .||..|.:..|.:.|.......::.|||......:
Human   294 QPVE----IMTYVTWKLSTFPANRVIGIGCNLDSQRLQYIITNVLKAQTSGKEVWVIGEQGEDKV 354

  Fly   206 LPVLSQSQPLFKGNQDTIEKLT-VRIQEAGTEVVKAKAGAGSATLSMAYAGARFAGSLLKGLNGE 269
            |        .:.|.::.:...: |::.....|:::.|   |..:.|:..:.|....|:   :|.:
Human   355 L--------TWSGQEEVVSHTSQVQLSNRAMELLRVK---GQRSWSVGLSVADMVDSI---VNNK 405

  Fly   270 KNVIECSYVQS---TVTEATFFSTPLVLGKNGVQE 301
            |.|...|.:..   .:....|.|.|.:||.|||.|
Human   406 KKVHSVSALAKGYYDINSEVFLSLPCILGTNGVSE 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdh2	NP_650696.1	MDH_glyoxysomal_mitochondrial	25..334	CDD:133422	60/295 (20%)
UEVLD	NP_001035787.1	UEV	21..138	CDD:283415
		PLN02602	161..471	CDD:178212	60/295 (20%)
		LDH_1	180..468	CDD:133429	60/295 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810