Protein Alignment Mdh2 and MDH2

DIOPT Version :9

• Sequence 1: NP_650696.1
• Gene: Mdh2 / 42185
• FlyBaseID: FBgn0262559
• Length: 336
• Species: Drosophila melanogaster
• Sequence 2: NP_005909.2
• Gene: MDH2 / 4191
• HGNCID: 6971
• Length: 338
• Species: Homo sapiens
• Alignment Length: 333
• Identity: 199/333 - (59%)
• Similarity: 258/333 - (77%)
• Gaps: 0/333 - (0%)

  Fly     1 MLKQVTKQLALQGVRTFSVGQQNNYKVTVCGAAGGIGQPLSLLLKQNPLVTDLALYDIVHTPGVA 65
            ||..:.:..:....|:||...|||.||.|.||:||||||||||||.:|||:.|.||||.||||||
Human     1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVA 65

  Fly    66 ADLSHIDTKSKTAGFIGADQLGDSLKGSDVVVIPAGVPRKPGMTRDDLFNVNAGIIKDISNSIAK 130
            ||||||:||:...|::|.:||.|.|||.||||||||||||||||||||||.||.|:..::.:.|:
Human    66 ADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQ 130

  Fly   131 NCPKALVAIITNPVNTCVPIAAEILKKAGVYDPKRLFGVSTLDVVRARAFIGHALGVDPQTVQIP 195
            :||:|::.:|.||||:.:||.||:.||.|||:|.::|||:|||:|||..|:....|:||..|.:|
Human   131 HCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVP 195

  Fly   196 VIGGHSGVTILPVLSQSQPLFKGNQDTIEKLTVRIQEAGTEVVKAKAGAGSATLSMAYAGARFAG 260
            |||||:|.||:|::||..|.....||.:..||.||||||||||||||||||||||||||||||..
Human   196 VIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVF 260

  Fly   261 SLLKGLNGEKNVIECSYVQSTVTEATFFSTPLVLGKNGVQENLGLPKLNDYEKKLLEAAIPELKK 325
            ||:..:||::.|:|||:|:|..||.|:|||||:|||.|:::|||:.|::.:|:|::..||||||.
Human   261 SLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKA 325

  Fly   326 NIQKGIDF 333
            :|:||.||
Human   326 SIKKGEDF 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdh2	NP_650696.1	MDH_glyoxysomal_mitochondrial	25..334	CDD:133422	191/309 (62%)
MDH2	NP_005909.2	MDH_glyoxysomal_mitochondrial	26..334	CDD:133422	191/308 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150893
Domainoid	1	1.000	200	1.000	Domainoid score	I3047
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55938
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1877
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56560
OrthoDB	1	1.010	-	-		D366623at33208
OrthoFinder	1	1.000	-	-		FOG0001716
OrthoInspector	1	1.000	-	-		oto90853
orthoMCL	1	0.900	-	-		OOG6_101212
Panther	1	1.100	-	-	LDO	PTHR11540
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R700
SonicParanoid	1	1.000	-	-		X1106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800