DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdh2 and MDH1

DIOPT Version :9

Sequence 1:NP_650696.1 Gene:Mdh2 / 42185 FlyBaseID:FBgn0262559 Length:336 Species:Drosophila melanogaster
Sequence 2:NP_001303303.1 Gene:MDH1 / 4190 HGNCID:6970 Length:353 Species:Homo sapiens


Alignment Length:360 Identity:89/360 - (24%)
Similarity:144/360 - (40%) Gaps:81/360 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 KVTVCGAAGGIGQPL-------SLLLKQNPLVTDLALYDIVHTP------GVAADLSHIDTKSKT 77
            :|.|.||||.|...|       |:..|..|::  |.|.||  ||      ||..:|... .....
Human     6 RVLVTGAAGQIAYSLLYSIGNGSVFGKDQPII--LVLLDI--TPMMGVLDGVLMELQDC-ALPLL 65

  Fly    78 AGFIGADQLGDSLKGSDVVVIPAGVPRKPGMTRDDLFNVNAGIIKDISNSIAKNCPKAL-VAIIT 141
            ...|..|:...:.|..||.::...:||:.||.|.||...|..|.|....::.|...|:: |.::.
Human    66 KDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVG 130

  Fly   142 NPVNT-CVPIAAEILKKAGVYDPKRLFGVST-LDVVRARAFIGHALGVDPQTVQIPVIGGHSGVT 204
            ||.|| |:..:     |:....||..|...| ||..||:|.|...|||....|:..:|.|:...|
Human   131 NPANTNCLTAS-----KSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSST 190

  Fly   205 ILPVLSQSQPLFKGNQDTI-----------EKLTVRIQEAGTEVVKAKAGAGSATLSMAYAGARF 258
            ..|.::.::...:|.:..:           .:....:|:.|..|:||:      .||.|.:.|:.
Human   191 QYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKAR------KLSSAMSAAKA 249

  Fly   259 AGSLLKGLNGEKNVIECSYVQST---VTEATFFSTPLVLGKN--GVQENL--------------- 303
            .               |.:|:..   ..|..|.|..::...|  ||.::|               
Human   250 I---------------CDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKF 299

  Fly   304 --GLPKLNDYEKKLLEAAIPELKKNIQKGIDFANA 336
              ||| :||:.::.::....||.:..:...:|.::
Human   300 VEGLP-INDFSREKMDLTAKELTEEKESAFEFLSS 333

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdh2NP_650696.1 MDH_glyoxysomal_mitochondrial 25..334 CDD:133422 88/356 (25%)
MDH1NP_001303303.1 MalateDH-SF1 2..327 CDD:130820 88/352 (25%)
MDH_cytoplasmic_cytosolic 3..328 CDD:133421 88/353 (25%)
PTS1 351..353
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0039
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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