Protein Alignment Mdh2 and LDHC

DIOPT Version :10

• Sequence 1: NP_650696.1
• Gene: Mdh2 / 42185
• FlyBaseID: FBgn0262559
• Length: 336
• Species: Drosophila melanogaster
• Sequence 2: NP_002292.1
• Gene: LDHC / 3948
• HGNCID: 6544
• Length: 332
• Species: Homo sapiens
• Alignment Length: 338
• Identity: 96/338 - (28%)
• Similarity: 146/338 - (43%)
• Gaps: 47/338 - (13%)

  Fly    21 QQNNYKVTVCG-AAGGIGQPLSLLLKQNPLVTDLALYDIV--HTPGVAADLSH----IDTKSKTA 78
            :.:..|:|:.| .|.|:...:|:|||.  |..:|||.|:.  ...|...||.|    ..|...|:
Human    17 ENSQCKITIVGTGAVGMACAISILLKD--LADELALVDVALDKLKGEMMDLQHGSLFFSTSKITS 79

  Fly    79 G---FIGADQLGDSLKGSDVVVIPAGVPRKPGMTRDDLFNVNAGIIKDISNSIAKNCPKALVAII 140
            |   .:.|:        |.:|::.||..::.|.||..|...|..|:|.|..:|....|...:.::
Human    80 GKDYSVSAN--------SRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSPDCKILVV 136

  Fly   141 TNPVNTCVPIAAEILKKAGVYDPKRLFGVS-TLDVVRARAFIGHALGVDPQTVQIPVIGGH---- 200
            :|||:    |...|:.|.......|:.|.. .||..|.|..||..|||.|.:....:||.|
Human   137 SNPVD----ILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSS 197

  Fly   201 ----SGVTILPV-LSQSQPLFKGNQD-----TIEKLTVRIQEAGTEVVKAKAGAGSATLSMAYAG 255
                |||.:..| |....|....:.|     .|.|   ::.::..|::|.|   |..:.::..:.
Human   198 VPLWSGVNVAGVALKTLDPKLGTDSDKEHWKNIHK---QVIQSAYEIIKLK---GYTSWAIGLSV 256

  Fly   256 ARFAGSLLKGLNGEKNVIECSYVQSTVTEATFFSTPLVLGKNGVQENLGLPKLNDYEKKLLEAAI 320
            ....||:||.|.....|.........:.|..|.|.|.|||:|||.:.:.: .||..|:.|.:.:
Human   257 MDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGVSDVVKI-NLNSEEEALFKKS- 319

  Fly   321 PELKKNIQKGIDF 333
            .|...||||.:.|
Human   320 AETLWNIQKDLIF 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdh2	NP_650696.1	MDH_glyoxysomal_mitochondrial	25..334	CDD:133422	96/334 (29%)
LDHC	NP_002292.1	LDH_1	18..329	CDD:133429	94/332 (28%)