DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdh2 and Mdh1

DIOPT Version :9

Sequence 1:	NP_650696.1	Gene:	Mdh2 / 42185	FlyBaseID:	FBgn0262559	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_001303806.1	Gene:	Mdh1 / 24551	RGDID:	3072	Length:	355	Species:	Rattus norvegicus

Alignment Length:	347	Identity:	89/347 - (25%)
Similarity:	149/347 - (42%)	Gaps:	55/347 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KVTVCGAAGGIGQPL-------SLLLKQNPLVTDLALYDIVHTP------GVAADLSHIDTKSKT 77
            :|.|.||||.|...|       |:..|..|::  |.|.||  ||      ||..:|... .....
  Rat     6 RVLVTGAAGQIAYSLLYSIGNGSVFGKDQPII--LVLLDI--TPMMGVLDGVLMELQDC-ALPLL 65

  Fly    78 AGFIGADQLGDSLKGSDVVVIPAGVPRKPGMTRDDLFNVNAGIIKDISNSIAKNCPKAL-VAIIT 141
            ...|..|:...:.|..||.|:...:||:.||.|.||...|..|.|....::.|...|:: |.::.
  Rat    66 QDVIATDKEEVAFKDLDVAVLVGSMPRREGMERKDLLKANVKIFKSQGAALEKYAKKSVKVIVVG 130

  Fly   142 NPVNT-CVPIAAEILKKAGVYDPKRLFGVST-LDVVRARAFIGHALGVDPQTVQIPVIGGHSGVT 204
            ||.|| |:..:     |:....||..|...| ||..||::.|...|||....|:..:|.|:...|
  Rat   131 NPANTNCLTAS-----KSAPSIPKENFSCLTRLDHNRAKSQIALKLGVTADDVKNVIIWGNHSST 190

  Fly   205 ILPVLSQSQPLFKGNQDTI------------EKLTVRIQEAGTEVVKAKAGAGSATLSMAYAGAR 257
            ..|.::.::...:|.:..:            |.:|. :|:.|..|:||:      .||.|.:.|:
  Rat   191 QYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFITT-VQQRGAAVIKAR------KLSSAMSAAK 248

  Fly   258 FAGSLLKGL---NGEKNVIECSYVQS----TVTEATFFSTPLVLGKNGVQENL-GLPKLNDYEKK 314
            .....::.:   ..|...:....:..    .|.:...:|.|:|: ||...:.: ||| :||:.::
  Rat   249 AISDHIRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVI-KNKTWKFVEGLP-INDFSRE 311

  Fly   315 LLEAAIPELKKNIQKGIDFANA 336
            .::....||.:..:...:|.::
  Rat   312 KMDLTAKELTEEKETAFEFLSS 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdh2	NP_650696.1	MDH_glyoxysomal_mitochondrial	25..334	CDD:133422	88/343 (26%)
Mdh1	NP_001303806.1	MalateDH-SF1	2..327	CDD:130820	88/339 (26%)
		MDH_cytoplasmic_cytosolic	3..328	CDD:133421	88/340 (26%)
		PTS1	353..355
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810