DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdh2 and Mdh1

DIOPT Version :9

Sequence 1:	NP_650696.1	Gene:	Mdh2 / 42185	FlyBaseID:	FBgn0262559	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_001303604.1	Gene:	Mdh1 / 17449	MGIID:	97051	Length:	355	Species:	Mus musculus

Alignment Length:	348	Identity:	93/348 - (26%)
Similarity:	153/348 - (43%)	Gaps:	57/348 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KVTVCGAAGGIGQPL-------SLLLKQNPLVTDLALYDIVHTP------GVAADLSHIDTKSKT 77
            :|.|.||||.|...|       |:..|..|::  |.|.||  ||      ||..:|... .....
Mouse     6 RVLVTGAAGQIAYSLLYSIGNGSVFGKDQPII--LVLLDI--TPMMGVLDGVLMELQDC-ALPLL 65

  Fly    78 AGFIGADQLGDSLKGSDVVVIPAGVPRKPGMTRDDLFNVNAGIIKDISNSIAKNCPKAL-VAIIT 141
            ...|..|:...:.|..||.|:...:||:.||.|.||...|..|.|....::.|...|:: |.::.
Mouse    66 QDVIATDKEEIAFKDLDVAVLVGSMPRREGMERKDLLKANVKIFKSQGTALEKYAKKSVKVIVVG 130

  Fly   142 NPVNT-CVPIAAEILKKAGVYDPKRLFGVST-LDVVRARAFIGHALGVDPQTVQIPVIGGHSGVT 204
            ||.|| |:..:     |:....||..|...| ||..||::.|...|||....|:..:|.|:...|
Mouse   131 NPANTNCLTAS-----KSAPSIPKENFSCLTRLDHNRAKSQIALKLGVTADDVKNVIIWGNHSST 190

  Fly   205 ILPVLSQSQPLFKGNQDTI------------EKLTVRIQEAGTEVVKAK--AGAGSATLSMA--- 252
            ..|.::.::...:|.:..:            |.:|. :|:.|..|:||:  :.|.||..::|
Mouse   191 QYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFITT-VQQRGAAVIKARKLSSAMSAAKAIADHI 254

  Fly   253 ---YAGARFAGSLLKGLNGEKNVIECSYVQSTVTEATFFSTPLVLGKNGVQENL-GLPKLNDYEK 313
               :.|......:..|:..:.|    ||   .|.:...:|.|:|: ||...:.: ||| :||:.:
Mouse   255 RDIWFGTPEGEFVSMGVISDGN----SY---GVPDDLLYSFPVVI-KNKTWKFVEGLP-INDFSR 310

  Fly   314 KLLEAAIPELKKNIQKGIDFANA 336
            :.::....||.:..:...:|.::
Mouse   311 EKMDLTAKELTEEKETAFEFLSS 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdh2	NP_650696.1	MDH_glyoxysomal_mitochondrial	25..334	CDD:133422	92/344 (27%)
Mdh1	NP_001303604.1	MalateDH-SF1	2..327	CDD:130820	92/340 (27%)
		MDH_cytoplasmic_cytosolic	3..328	CDD:133421	92/341 (27%)
		PTS1	353..355
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910