DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdh2 and Ldhb

DIOPT Version :9

Sequence 1:	NP_650696.1	Gene:	Mdh2 / 42185	FlyBaseID:	FBgn0262559	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_001303251.1	Gene:	Ldhb / 16832	MGIID:	96763	Length:	341	Species:	Mus musculus

Alignment Length:	342	Identity:	87/342 - (25%)
Similarity:	145/342 - (42%)	Gaps:	65/342 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 NYKVTVCGAAGGIGQPLSLLLKQNPLVTDLALYDIVH--TPGVAADLSHIDTKSKTAGFIGADQL 86
            |.|:||.| .|.:|...::.:....|..:|||.|::.  ..|...||.|.....:|...: ||:.
Mouse    21 NNKITVVG-VGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIV-ADKD 83

  Fly    87 GDSLKGSDVVVIPAGVPRKPGMTRDDLFNVNAGIIKDISNSIAKNCPKALVAIITNPVNTCVPIA 151
            ......|.:||:.|||.::.|.:|.:|...|..:.|.|...|.|..|...:.:::|||:....:.
Mouse    84 YSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCTIIVVSNPVDILTYVT 148

  Fly   152 AEILKKAGVYDPK-RLFGVS-TLDVVRARAFIGHALGVDPQTVQIPVIGGH--------SGVTIL 206
               .|.:|:  || |:.|.. .||..|.|..:...||:.|.:....::|.|        |||.:.
Mouse   149 ---WKLSGL--PKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVA 208

  Fly   207 PV-LSQSQPLFKGNQDT-----IEKLTVRIQEAGTEVVKAKA------GAGSATL--SMAYAGAR 257
            .| |.:..|....:.|:     :.|:.|   ::..||:|.|.      |...|.|  ||....:|
Mouse   209 GVSLQELNPEMGTDNDSENWKEVHKMVV---DSAYEVIKLKGYTNWAIGLSVADLIESMLKNLSR 270

  Fly   258 F--AGSLLKGLNGEKNVIECSYVQSTVTEATFFSTPLVLGKNGVQENLGLPKLNDYEKKLLEAAI 320
            .  ..:::||:.|.:|.:             |.|.|.:|...|:...:        .:||.:..:
Mouse   271 IHPVSTMVKGMYGIENEV-------------FLSLPCILNARGLTSVI--------NQKLKDDEV 314

  Fly   321 PELKK------NIQKGI 331
            .:|:|      :|||.:
Mouse   315 AQLRKSADTLWDIQKDL 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdh2	NP_650696.1	MDH_glyoxysomal_mitochondrial	25..334	CDD:133422	86/341 (25%)
Ldhb	NP_001303251.1	LDH_1	20..330	CDD:133429	86/339 (25%)
		L-LDH-NAD	26..326	CDD:273796	81/330 (25%)
		PTS1	339..341
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810