Protein Alignment Mdh2 and MDH1B

DIOPT Version :10

• Sequence 1: NP_650696.1
• Gene: Mdh2 / 42185
• FlyBaseID: FBgn0262559
• Length: 336
• Species: Drosophila melanogaster
• Sequence 2: NP_001034934.1
• Gene: MDH1B / 130752
• HGNCID: 17836
• Length: 518
• Species: Homo sapiens
• Alignment Length: 237
• Identity: 52/237 - (21%)
• Similarity: 80/237 - (33%)
• Gaps: 44/237 - (18%)

  Fly   115 NVNAGIIKDISNSIAKNCPKALVAIITNPVNTCVPIAAEILKKAGVYDPKRLFGVSTLDVVRARA 179
            |:.|.|.|:......|.|...|...||:...........||....|:.......::..|..:|..
Human   111 NLGAHIEKEQEEEALKTCINPLQVWITSASAPACYNLIPILTSGEVFGMHTEISITLFDNKQAEE 175

  Fly   180 FIGHALGVDPQTVQIPVIGGHSGVT----------ILPVLSQSQ---------------PLFKGN 219
            .: .:|.|:.|.:..||:...|..|          ::.||..|.               ||.:..
Human   176 HL-KSLVVETQDLASPVLRSVSICTKVEEAFRQAHVIVVLDDSTNKEVFTLEDCLRSRVPLCRLY 239

  Fly   220 QDTIEK---LTVRIQEAGTEVVKAKAGAGSATLSMAYAGARFAGSLLK---GLNGEKNVIECSYV 278
            ...|||   .:||:...|...|..|     ..|.|.|| .|.|.:::.   |:.||...|   ..
Human   240 GYLIEKNAHESVRVIVGGRTFVNLK-----TVLLMRYA-PRIAHNIIAVALGVEGEAKAI---LA 295

  Fly   279 QSTVTEATFFSTPLVLGKNGVQENLGLPKLNDYEKKLLEAAI 320
            :...|..::....::.|.......:.|.|...|.   .|:||
Human   296 RKLKTAPSYIKDVIIWGNISGNNYVDLRKTRVYR---YESAI 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdh2	NP_650696.1	MDH_glyoxysomal_mitochondrial	25..334	CDD:133422	52/237 (22%)
MDH1B	NP_001034934.1	MDH_like	9..459	CDD:133431	52/237 (22%)