DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7168 and COMMD2

DIOPT Version :9

Sequence 1:	NP_650695.1	Gene:	CG7168 / 42184	FlyBaseID:	FBgn0038586	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	NP_057178.2	Gene:	COMMD2 / 51122	HGNCID:	24993	Length:	199	Species:	Homo sapiens

Alignment Length:	236	Identity:	72/236 - (30%)
Similarity:	118/236 - (50%)	Gaps:	47/236 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRLTQQQRNHLSLLQKPASAVV-ELCKSAFDYLINGPNPSRYEMLAKK---SSDLGSPEAVQQAV 64
            |.|:::.:.||:.|.:..|||| |..:.|.::|..|.||..||..|:|   |||     .||..|
Human     3 LELSEEHKEHLAFLPQVDSAVVAEFGRIAVEFLRRGANPKIYEGAARKLNVSSD-----TVQHGV 62

  Fly    65 EALISLLISVTTRVGSSSVD-MEAILRQTFPELGDDVIEVLEQFVTSKRNFVEGSIK--SANIRA 126
            |.| :.|::.::::..|.:| .:::....|.|   ::.::|.|.....|..:...:.  :.::.:
Human    63 EGL-TYLLTESSKLMISELDFQDSVFVLGFSE---ELNKLLLQLYLDNRKEIRTILSELAPSLPS 123

  Fly   127 YRLVNLDWRLEVRTASRSLLDQCQVVVTMKLYLHTEPKNENRELLAVDISGRSEQELKAMQEDER 191
            |.  ||:|||:|:.|||||..|.:..||:||:|     |:|.:
Human   124 YH--NLEWRLDVQLASRSLRQQIKPAVTIKLHL-----NQNGD---------------------- 159

  Fly   192 LHRKDLLVQTDVCSLVHMIKTLEDALAESKTRRIRNIVDGI 232
             |...:| |||..:|:|:::.||.||.|.||...|.:|..|
Human   160 -HNTKVL-QTDPATLLHLVQQLEQALEEMKTNHCRRVVRNI 198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7168	NP_650695.1	Commd	26..224	CDD:297546	60/203 (30%)
COMMD2	NP_057178.2	Commd2	26..190	CDD:240098	60/203 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153117
Domainoid	1	1.000	45	1.000	Domainoid score	I12277
eggNOG	1	0.900	-	-		E1_28MHC
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	78	1.000	Inparanoid score	I5248
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55677
OrthoDB	1	1.010	-	-		D1458356at2759
OrthoFinder	1	1.000	-	-		FOG0008101
OrthoInspector	1	1.000	-	-		oto89394
orthoMCL	1	0.900	-	-		OOG6_106223
Panther	1	1.100	-	-	LDO	PTHR15857
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5388
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800